Executive Director, Portfolio & Program Management

Job Description The Executive Director, Portfolio & Program Management is a global leadership role within the Program and Portfolio Management (PPM) organization. The role is accountable for all program management efforts across the drug development lifecycle and commercialization, including Disease Area Strategy Teams (DST), Program Teams (PT), and research PTs, ensuring end‑to‑end integration with DST strategy for a subset of Vertex's portfolio diseases. This role drives organizational design, strategic growth, and operational excellence, with expanded scope to lead multiple disease areas and mentor senior program managers. This position is based in our Boston, MA location (Seaport area) and requires a hybrid work schedule with 3 days in office / 2 days remote on a weekly basis. Key Duties & Responsibilities Provide strategic and operational leadership to multiple cross‑functional teams, spanning research, clinical, and marketed products. Lead and mentor Senior Directors and PPM staff across at least one additional disease area ("player/coach" model). Drive synergies and scalability across disease areas, optimizing resource allocation to deliver on Vertex portfolio priorities. Set strategy and oversee decision‑making for high‑priority and complex programs, ensuring alignment with corporate objectives. Champion organizational design principles to enable agile, scalable teams and career development opportunities. Represent PPM on governance forums and with senior leaders, influencing strategic direction and portfolio growth. Propose and implement innovative approaches and process improvements to maximize operational excellence. Oversee financial and human resource accountability for expanded teams (direct and indirect reports). Ensure integration of research, development, and commercialization of program management efforts with DST strategy. Basic Requirements Bachelor's degree in Life Sciences or a relevant field. Typically requires 15+ years of experience, including 7+ years of management experience, or the equivalent combination of education and experience. Demonstrated experience leading large, complex teams and programs at a global level. Knowledge and Skills Deep expertise in portfolio and program management, strategic planning, risk management and resource management across multiple disease areas. Proven ability to lead and mentor senior program managers and high‑level professionals. Advanced business management and financial acumen to drive value creation. Exceptional communication and collaboration skills with internal and external stakeholders. Strong organizational skills and ability to manage multiple priorities in a dynamic environment. Pharmaceutical drug discovery and development expertise across disciplines. Pay Range $260,800 - $391,200 Flex Designation Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid : work remotely up to two days per week; 2. On‑Site : work five days per week on‑site with ad hoc flexibility. Benefits At Vertex, our Total Rewards offerings include inclusive market‑leading benefits: medical, dental and vision benefits, generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs (including student loan repayment), commuter subsidy, charitable donations matching, 401(k) plus more. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io. #J-18808-Ljbffr Vertex Pharmaceuticals Incorporated