Senior Scientist, Computational Biology- Oncology Translational Research

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.comAs guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.Job Function: Discovery & Pre-Clinical/Clinical DevelopmentJob Sub Function: Translational Discovery & Development BiomarkersJob Category:Scientific/TechnologyAll Job Posting Locations:Cambridge, Massachusetts, United States of America, La Jolla, California, United States of America, Spring House, Pennsylvania, United States of AmericaJob Description:Senior Scientist, Computational Biology- Oncology Translational ResearchAbout Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at About Oncology Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at We are seeking a highly motivated senior scientist to join our translational research team based in Spring House, PA, Cambridge, MA, La Jolla, CA.Position SummaryThe Senior Scientist, Computational Biology- Oncology Translational Research, will be responsible for analysis, interpretation and integration of complex, multimodal omics, biomarker, and clinical data. The individual will apply rigorous AI-enabled bioinformatics, statistical, and machine-learning approaches to generate insights that meaningfully inform oncology clinical development, while partnering closely with Translational Research Leaders, Clinical Development, Statistics, Programming, Pathology, Diagnostics, Data Science, Regulatory, and Biomarker Operations.Essential Job Duties and ResponsibilitiesIndependently analyze multimodal oncology biomarker data and associated clinical outcomes, including DNA/RNA sequencing, flow cytometry, proteomics, single-cell and spatial transcriptomics data, applying cancer biology expertise, rigorous statistical and machine-learning methods to generate biologically and clinically relevant insight.Integrate molecular, pathological, and clinical data to identify, validate and evaluate pharmacodynamic, prognostic, predictive, and resistance biomarkers.Leverage computational evidence to support the development of translational strategies, using working knowledge of trial design, endpoints, and treatment response.Use approved AI-enabled tools responsibly to accelerate analysis, coding, testing, and documentation while ensuring that all outputs are reviewed, validated, traceable, and reproducible.Collaborate with cross-functional study and program teams; clearly communicate findings, uncertainty, and limitations; and contribute to publications, presentations, and evaluation of emerging computational and biomarker technologies.Required QualificationsPhD in Bioinformatics, Computational Biology, Biostatistics, Genomics, Data Science, or a related quantitative field, with 1-3 years of relevant pharmaceutical or biotechnology industry experience. Advanced proficiency in R, with experience in Python, wLinux/Unix, shell scripting, version control, and reproducible analysis of high-throughput sequencing and multimodal omics data.Demonstrated oncology translational or clinical-development experience, with strong knowledge of cancer biology, biomarker applications, and clinical-trial concepts.Strong statistical and machine-learning experience, including regression, multivariate data analysis, survival analysis, supervised learning, semi-supervised learning, unsupervised learning, reinforcement learning for the analysis of biomarker, assay, and clinical data.Ability to communicate complex analyses and their limitations clearly, collaborate across functions, and independently own defined study or biomarker-analysis workstreams.Demonstrated scientific accomplishments through peer-reviewed publications and scientific presentations.Preferred QualificationsFamiliarity with CDISC SDTM and ADaM data models, regulatory clinical data management practices, and biomarker-data traceability.Experience with deep learning, multimodal modeling, or responsible application of foundation models or agentic AI to biomedical research.Working knowledge of IND and NME development and Phase 1–3 clinical trials, including study design, dose escalation and expansion, analysis populations, clinical endpoints, longitudinal and time-to-event analyses, and interpretation of biomarker data as decision-informing evidence.Experience supporting patient-selection, companion or complementary diagnostic, regulatory, or submission-related biomarker activities.Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).This position is eligible to participate in the Company’s long-term incentive program.Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:Vacation –120 hours per calendar yearSick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar yearHoliday pay, including Floating Holidays –13 days per calendar yearWork, Personal and Family Time - up to 40 hours per calendar yearParental Leave – 480 hours within one year of the birth/adoption/foster care of a childBereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar yearCaregiver Leave – 80 hours in a 52-week rolling period10 daysVolunteer Leave – 32 hours per calendar yearMilitary Spouse Time-Off – 80 hours per calendar yearFor additional general information on Company benefits, please go to: - The anticipated base pay range for this position is:$105,000 - $169,050Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via , internal employees contact AskGS to be directed to your accommodation resource.#LI-HybridRequired Skills:Preferred Skills:Biomarkers, Clinical Trial Designs, Coaching, Communication, Critical Thinking, Drug Discovery Development, Human-Centered Design, Interdisciplinary Work, Medical Compliance, Medical Technology, Quality Standards, Research Documents, Safety-Oriented, Scientific Research, Technologically Savvy, Translational MedicineThe anticipated base pay range for this position is :$109,000.00 - $174,800.00Additional Description for Pay Transparency:SummaryLocation: Spring House, Pennsylvania, United States of America; Cambridge, Massachusetts, United States of America; La Jolla, California, United States of AmericaType: Full time