Director, Translational Immunology

Department: 106200 Research & Non-Clinical Dev Location: San Diego, USA- Remote Be a part of a global team that is inspired to make a difference in the lives of people living with rare disease. At Travere Therapeutics, we recognize that our exceptional employees are vital to our success. We are a dedicated team focused on meeting the unique needs of rare patients.Our work is rewarding - both professionally and personally - because we are making a difference. We are passionate about what we do. We are seeking talented individuals who will thrive in our collaborative, diverse, fast-paced environment and share in our mission - to identify, develop and deliver life-changing therapies to people living with rare disease. We stick by our values centered on patients, courage, community, and collaboration to pursue our vision of becoming a leading biopharmaceutical company dedicated to the delivery of innovation and hope to patients in the global rare disease community. At Travere Therapeutics, we are in rare for life. We continue to courageously forge new paths as we move toward a common goal of elevating science and service for rare patients . Position Summary: Travere Therapeutics is seeking an experienced and strategic scientist to join our Research and Nonclinical Development organization as Director, Translational Immunology. This individual will serve as a key scientific leader supporting an assigned development program primarily for rare-kidney disease and will play an important role in advancing translational and nonclinical strategies across current and future indications. The successful candidate will bring deep expertise in immunology and immune-mediated disease, including a strong understanding of B-cell biology combined with experience supporting clinical-stage drug development programs. Knowledge of kidney disease would be an advantage. This individual will work closely with Clinical Development, Clinical Pharmacology, Biometrics, Regulatory, Medical Affairs, and external collaborators to develop translational strategies, support nonclinical development activities, evaluate emerging scientific opportunities, and help identify additional indications where the asset may also provide meaningful therapeutic benefit. This role also represents an opportunity to contribute to the growth of immunology capabilities within a dynamic Research and Nonclinical Development organization and to assume increasing scientific leadership responsibilities as the organization expands. Responsibilities : Program Leadership and Scientific Strategy Serve as the immunology lead supporting a late-stage clinical development program. Contribute to the development and execution of nonclinical and translational strategies aligned with program team objectives. Partner with cross-functional teams to support program governance, development planning, and scientific decision-making. Assess emerging scientific, clinical, and competitive developments relevant to assigned program and associated strategy. Contribute to the identification and evaluation of new therapeutic opportunities in rare disease for the assigned program that may provide clinical benefit. Translational Science and Biomarkers Develop translational strategies linking mechanism of action, target engagement, pharmacodynamic activity, and clinical outcomes. Support identification and implementation of mechanistic, pharmacodynamic, predictive, and response biomarkers. Collaborate with cross-functional teams to support implementation of biomarker strategies and data interpretation throughout development. Contribute to scientific publications, presentations, and external communications. Nonclinical Development and Regulatory Support Collaborate with Regulatory and nonclinical colleagues to support regulatory submissions and health authority interactions. Interpret pharmacology, toxicology, and translational data in the context of clinical development and regulatory objectives. Support preparation and review of investigator brochures, briefing documents, regulatory submissions, and other development-related documents. Ensure research and translational activities are aligned with development plans and regulatory expectations. External Scientific Leadership Lead scientific interactions with CROs, academic collaborators, consultants, and key opinion leaders. Design, oversee, and contribute to interpretation of externally conducted translational and mechanistic nonclinical studies. Represent Travere at scientific meetings, conferences, and external collaborations. Identify and build productive scientific relationships that advance understanding of disease biology and therapeutic mechanisms. Organizational Leadership Contribute to building immunology and translational science capabilities within the Research and Nonclinical Development organization. Mentor colleagues and provide scientific leadership across programs and functions. Foster a culture of scientific excellence, collaboration, innovation, and continuous learning. Demonstrate the potential and desire to assume increasing scientific leadership responsibilities as the organization grows. Immunology and Disease Biology Provide deep scientific expertise in B-cell biology, adaptive immunity, and innate immune signaling. * Evaluate disease mechanisms and therapeutic opportunities in immune-mediated and rare diseases. Integrate mechanistic biology, translational science, and clinical observations to inform development strategies. Serve as an internal subject matter expert in immunology and immune-mediated disease biology. Maintain awareness of advances in disease biology, therapeutic targets, and emerging technologies relevant to immunology and translational medicine. Education/Experience Requirements: Bachelor's Degree in Life Science or other related discipline required. PhD, MD, PharmD, or equivalent advanced degree in Immunology, Cell Biology, Molecular Biology, Pharmacology, or a related scientific discipline preferred. Equivalent combination of education and applicable job experience may be considered. Minimum 10 years of relevant experience in the biopharmaceutical industry required; or 6 years with PhD, MD, PharmD, or equivalent. Demonstrated expertise in immunology, with strong knowledge of B-cell biology and immune signaling pathways. Experience supporting clinical-stage drug development programs. Experience translating mechanistic biology into development strategies and clinical applications. Experience leading externally conducted research through CROs, academic collaborators, and consultants. Working knowledge of regulatory requirements and expectations for nonclinical support of clinical development programs. Experience contributing to regulatory submissions, investigator brochures, briefing documents, or related development activities. Demonstrated ability to work effectively in cross-functional, matrixed organizations. Prior experience leading scientific initiatives, projects, or multidisciplinary teams. Excellent communication, presentation, and influencing skills. Scientific curiosity, intellectual rigor, and commitment to improving outcomes for patients with serious diseases. Ability to thrive in a collaborative, fast-paced, virtual biotechnology environment. Preferred Additional Skills/Experience Experience with immune signaling pathways. Experience with at least one or more of the following: autoimmune disease, inflammatory disease, rare disease, nephrology, or related therapeutic areas. Familiarity with at least one or more of the following: glomerular disease biology, proteinuric kidney diseases, podocytopathies, or mechanisms contributing to renal injury and disease progression. Experience supporting biomarker strategy and translational medicine initiatives. Experience evaluating disease mechanisms and identifying opportunities for therapeutic expansion into new indications. Experience serving as a scientific lead or key contributor on multidisciplinary development teams. Ability to integrate diverse scientific data sets to generate meaningful insights and guide decision-making. Strong project leadership and organizational skills. All positions have an essential job function to be able to perform face to face work with colleagues and/or onsite in San Diego. No role is expected to be 100% remote. Total Rewards Offerings : Travere provides comprehensive total rewards offerings that demonstrate our commitment as a diverse, equitable, people-centric, and pay-for-performance organization. Benefits: Our benefits include premium health, financial, work-life and well-being offerings for eligible employees and dependents, wellness and employee support programs, life insurance, disability, retirement plans with employer match and generous paid time off. Compensation : Our competitive compensation package includes a combination of both cash compensation (base pay and short-term incentive) and long-term incentive compensation (company stock), designed to recognize, retain, and reward employees. Target Base Pay Range: $189,000.00 - $246,000.00 *This information is current as of the date of this posting and may be modified in the future. Actual pay offered to a candidate will depend on a variety of factors including the candidate's experience, education, skills, and location. Travere will accept applications on an ongoing basis until a candidate is selected for the position. Travere Therapeutics, Inc. is an EEO/AA/Veteran/Disability Employer. If you require a reasonable accommodation to complete the application or interview process, please contact us by sending an email to View email address on click.appcast.io. Please note that this email address is to be used exclusively to request an accommodation with the online application, interview or hiring process only. Travere HR will not reply to emails sent to this address for any other reason. Travere Therapeutics