Principal Scientist, Obesity Mechanisms & MoA
Jobleads-US
Novo Nordisk is seeking a Principal Scientist for Emerging Obesity Mechanisms in Lexington, MA, to lead the obesity/comorbidity portfolio from discovery through IND readiness. You will drive cross-functional biology efforts, shape MoA datasets, and mentor junior scientists in a high-impact environment.
The role emphasizes disease expertise in obesity-related comorbidities, collaboration with global teams, and prioritizing human-relevant models to accelerate therapy development.
#J-18808-Ljbffr Jobleads-US$180k - $235k
...Department The US-based Emerging Obesity Mechanisms department delivers... ...you a driven and passionate scientist with a strong scientific background... ...seeking a highly motivated Principal Scientist to join our... ...build robust, translatable MoA-based datasets across small‑...PrincipalLocal areaFlexible hours- ...Senior/Principal Scientist, MPN Biology, Translational Sciences PharmaEssentia Innovation Research Center (PIRC) is seeking a highly... ..., in vivo pharmacology, translational biomarker and mechanism of action (MOA) studies to drive novel MPN therapeutics from project conception...PrincipalContract work
$154.4k - $242.55k
...best of my knowledge.Job DescriptionJoin Takeda as a Senior/Principal Scientist, Cell Based-Potency Assay Development. As an expert professional... ...management across biologics programs. You will translate mechanism of action insights into phase-appropriate analytical methods...PrincipalMinimum wageContract workLocal area- ...adherence and health outcomes. Summary of Position : The Principal Scientist - Formulation is an experienced scientific leader who will... ...-release formulation technologies and drug release mechanisms. Strong understanding of formulation-process-performance...PrincipalLocal area
- Description: Viken Detection is seeking a highly experienced Principal Mechanical Engineer to provide technical leadership and architectural ownership across our advanced detection and imaging systems. This highest-level individual contributor role sets mechanical design...PrincipalFull timeLocal areaRelocation package
$138.6k - $257.4k
...seeking a highly motivated and experienced scientist to lead a small group of biologists with... ...early target identification through mechanism of action studies to accelerate the development... ...DescriptionInternal Job Title: Senior Principal Scientist/Associate DirectorPosition...PrincipalFull time$175k - $225k
...Scholar Rock is seeking an accomplished and highly collaborative Principal Scientist, Biomarker Development, to provide scientific leadership for... ..., and interpretation.Integrate biological hypotheses and mechanism of action into fit-for-purpose biomarker approaches that...PrincipalFull time$146k - $236k
...feasibility, competitive differentiation) Quantify probability of pharmacological success by integrating uncertainty across compound, mechanism, and disease dimensions Translate scientific complexity into recommendations stakeholders can carry and defend in their own...Principal- ...150k - $200kA rapidly growing robotics and industrial automation startup in the Greater Boston area is hiring a full-time Senior Mechanical Engineer to develop advanced robotic systems that are transforming automotive service through automation. This role focuses on the...PrincipalFull time
$168k - $252k
...) cycle and translate them into scientifically rigorous AI co-scientists that enhance compound design, knowledge synthesis, data interpretation... ...management, approval workflows, monitoring, and intervention mechanisms.Drive adoption through scientist engagement, education, change...PrincipalFull timeSummer workRemote workFlexible hours2 days per week3 days per week$214.1k - $337k
Job DescriptionSenior Principal Scientist - Boston, MAOverviewWe are seeking a Senior Principal Scientist to provide scientific and strategic... ...and execute mass spectrometry-based assays that inform mechanism, potency, selectivity, exposure-response, and translational...PrincipalFull timeFor contractorsLocal area$122.25k - $176.58k
Job title: Principal ScientistLocation: Waltham, MAAbout the JobThe Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the... ...Group located in Waltham, MA in the role of Senior Scientist. The Genomic Medicine Cell Therapy Development group within Sanofi...PrincipalFull time- The Principal Mechanical Engineer will work directly as a member of a new product development team, applying their mechanical expertise to deliver a novel, integrated system to solve immediate customer challenges. They will at times work independently on pieces of systems...PrincipalContract workWork experience placementImmediate start
$122.25k - $176.58k
Job Title: Principal Scientist, Systems and Disease BiologyLocation: Cambridge, MAAbout the JobAs a Principal Scientist within our Systems and Disease Biology Cluster, you will decode disease mechanisms at cellular resolution and pioneer AI-powered workflows that accelerate...PrincipalFull time- ...applicants must be eligible to work in the US. Your Role:The Principal Scientist / Lab Head, In Vivo Pharmacology reports to the Head of... ...advancement.Contribute to target validation, candidate selection, mechanism-of-action studies, and translational pharmacology packages...PrincipalFlexible hours
$147.2k - $220.8k
...part of a team responsible for understanding the disposition mechanisms and pharmacokinetic/pharmacodynamic (PK/PD) relationships... ...closely with colleagues across Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK),...PrincipalFull timeTemporary workWork at officeLocal areaFlexible hours$173.2k - $272.6k
...DescriptionWe are seeking an accomplished and highly motivated Principal Scientist to provide strategic and scientific biomarker leadership... ...decision-centric biomarker strategies that integrate therapeutic mechanism, disease biology, pharmacodynamics, patient heterogeneity,...PrincipalFull timeFor contractorsLocal areaFlexible hours- ...Description About the Role We are seeking an experienced mechanical engineer to support the continued development of the Stride Shuttle... ...scope, this position may be filled at the Senior or Principal Engineer level. What You’ll Do Develop a strong system-level...PrincipalImmediate start
$216k - $297k
...will be a hands-on lead for a team of talented machine learning scientists innovating on model architectures that will create best-in-... ...the system can ingest and reason over modalities relevant to mechanism-of-action reasoning, target discovery, perturbation biology, pathway...Principal$142k - $215.2k
...Please do not share outside of the organization.Your Role:The Principal Scientist, Translational Quantitative Pharmacology (TQP) position in... ...competence in mathematical modeling of pharmacologic effects with mechanism-based models using relevant software or programming...PrincipalLocal areaImmediate start$142.5k - $256.5k
...RoleModerna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research... ..., epitope diversity, developability, potency, and mechanism of action.Partner with antigen design, structural biology, computational...PrincipalPermanent employmentFull timeWork from home$214.1k - $337k
...Merck seeks a Senior Principal Scientist to lead mass spectrometry capabilities within the Quantitative Biosciences group in Boston. The role... ...with multidisciplinary teams to develop assays informing mechanism, potency, selectivity, and translational decisions Provide...PrincipalLocal area- Sanofi is seeking a Principal Scientist in Cambridge, MA to decode disease mechanisms at cellular resolution and pioneer AI-powered workflows that accelerate discovery to patient impact. The role demands deep expertise in complex cellular analytics, multi-omics, and ML/...Principal
- BMS is seeking a Principal Scientist in Translational Informatics and Predictive Sciences to apply computational, bioinformatics, and ML approaches... ...clinical teams to inform treatment response and resistance mechanisms, while providing scientific leadership and mentorship. #J-...Principal
$155k - $193k
...Boston Dynamics is looking for a Principal Mechanical Engineer to join our Atlas team. We are seeking a Principal Mechanical Engineer to set the architectural vision for high-performance Actuator Products on next-generation humanoid robotic platforms. This role sits at...PrincipalFull timeVisa sponsorship$114.1k - $211.9k
...understanding of biomarker applications including target engagement, pharmacodynamics, patient stratification, disease activity, and mechanism-based biomarkers.Experience leading cross-functional matrix teams and influencing scientific strategy without direct authority....PrincipalFull timeLocal areaFlexible hours- ...Job Description Job Description General Summary: The Principle Mechanical Engineer role manages all aspects and phases of medical device development as part of a highly collaborative team in a fast-paced environment. Proven experience in bringing complex mechanical...PrincipalFor contractorsWork at officeNight shift
- ...GSK Oligonucleotide Conjugation Scientist At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding...PrincipalFull time
$108k - $128k
...Principal Associate Scientist Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines... ...pharmacodynamic and response biomarkers may help translate the mechanism toward development. The successful candidate will...PrincipalShift work- ...paced environment where requirements may shift and decisions need to be made with limited information. Requirements ~ BS in Mechanical Engineering, Robotics Engineering or equivalent ~5-8 years applicable professional experience in the robotics or automation industry...PrincipalShift work
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