Associate Director/Director, Commercial Data Management

Who We Are: Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team. What We Do: We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are important pain targets. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations. About the Role: We are seeking an Associate Director / Director, Commercial Data Management, to help build and operate a trusted, governed, analytics-ready commercial data ecosystem in support of Xenon’s first anticipated product launch in epilepsy. This role will serve as a key commercial business owner for commercial data management, master data management, data quality, data governance operations, reporting-ready data, and commercial data partner coordination. The role will ensure Xenon’s commercial data assets are accurate, timely, standardized, well-governed, and usable for launch performance measurement, field execution, targeting, segmentation, patient journey analytics, market access reporting, omnichannel measurement, and executive decision-making. The role will also ensure Xenon’s commercial data foundation is structured, governed, and sufficiently high quality to support future AI/ML-enabled capabilities, including predictive analytics, dynamic segmentation, next-best-action, automated insight generation, and launch performance optimization. Key partnerships for this role will span the entire Xenon commercial organization, including Analytics, Sales & Field Effectiveness, Market Access, and IT, as well as core vendor partnerships to manage the Commercial Data Ecosystem. This position reports to the Senior Director, Data Strategy, Operations, Analytics & Reporting and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.

RESPONSIBILITIES:

Commercial Data Management & Operating Model Collaborate with internal and external partners on developing and operationalizing Xenon’s commercial data ecosystem across pre-launch, launch, and post-launch phases Manage and define how commercial data will be governed, documented, validated, accessed, escalated, and used across the organization Serve as the primary commercial business partner managing Xenon’s core data service partners (e.g. CDW, Data Aggregator, MDM, etc.) and data source partners, (e.g. Claims, Rx, SP, Payer, etc.) IT Partnership Partner closely with IT on commercial data platform implementation, platform enhancements, system dependencies, integration patterns, security, compliance, performance, lineage, and architecture alignment Translate cross-functional commercial priorities into clear data management requirements, data ownership models, business rules, decision rights, and operating processes Master Data Management — HCP/HCO, Payer & Commercial Identity Serve as a commercial business owner or key steward for commercial master data management across HCP, HCO, affiliations, addresses, hierarchy, payer, payer bridge, customer master, and related identity domains Establish and maintain data dictionaries, critical data elements, metadata, lineage, and business definitions for priority commercial master data domains Data Quality Management & Data Stewardship Design and manage a data stewardship process to ensure data quality issues are identified, communicated, prioritized, and resolved through consistent business-facing processes Define, monitor, and evolve data quality rules, validation checks, reconciliation processes, completeness expectations, timeliness standards, accuracy thresholds, and issue escalation pathways Reporting-Ready Data, KPI Catalog & Business Definitions Support development of a governed KPI/metrics catalog into report-ready data assets with accompanying data dictionaries Translate KPI and dashboard requirements into upstream data definitions, business rules, transformation logic, and validation expectations, for reporting and dashboard use Commercial Data Warehouse & Data Aggregation Platform Partnership Partner with internal and vendor teams on go-live readiness (e.g. platform implementation, UAT, analytics/dashboards, etc.) and lifecycle management of data assets (e.g. Rx, Claims, CRM, payer, omnichannel engagement data, etc.) Define commercial requirements for ingestion, data mapping, transformation, quality control, data dissemination, archival, lineage, and reporting readiness Ecosystem, Vendor & SLA Management Coordinate cross-vendor dependencies to ensure commercial data flows are complete, accurate, timely, and aligned to launch and steady state needs Manage or support vendor deliverables including file layouts, data dictionaries, data transfer schedules, issue logs, quality checks, test files, SLA performance, and launch-readiness milestones

ADDITIONAL RESPONSIBILITIES:

Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any Some international travel may be required Other duties as assigned

QUALIFICATIONS:

Required Minimum undergraduate degree; 8+ years of relevant management experience or combination of degrees and experience Advanced degree in business, analytics, data management, information systems, life sciences, public health, or related field preferred 5+ years of experience in pharmaceutical, biotech, life sciences, healthcare data operations, data management, data governance, or related roles Experience working with most commercial data sources such as Rx, claims, CRM, HCP/HCO, payer, field activity, digital engagement, specialty pharmacy, hub/patient services, distribution, sales/inventory, formulary, or access data Experience supporting commercial data warehouse, data aggregation, MDM, data governance, data quality, reporting, or analytics initiatives Experience managing data vendors, data aggregators, MDM vendors, commercial data platforms, or analytics implementation partners Strong understanding of HCP/HCO and payer master data, affiliation management, data stewardship, business definitions, data dictionaries, metadata, lineage, and data quality management Ability to translate business needs into data requirements, business rules, vendor specifications, validation criteria, and operational processes Experience partnering with IT, analytics, vendors, Legal, Compliance, Privacy, and business stakeholders. Strong project management, vendor management, communication, documentation, and cross-functional leadership skills Ability to operate in a lean, fast-paced, pre-launch or launch-stage biotech environment Preferred Experience supporting a first commercial launch or commercial data capability build in a small or mid-sized biotech Experience with commercial data warehouse platforms, such as Snowflake, Azure, AWS, Boomi, Informatica, Veeva, Salesforce, IQVIA, Symphony, Komodo, MMIT, Definitive Healthcare, OneTrust, Power BI, Tableau, or related platforms/vendors Experience with tokenization/de-identification, claims/Rx data, SP/hub data, patient journey analytics, omnichannel engagement data, or field execution data Experience developing KPI catalogs, business glossaries, data dictionaries, quality rule catalogs, issue intake processes, or governed reporting-ready datasets Experience supporting data foundations for advanced analytics (e.g. AI/ML, next-best-action, predictive modeling, dynamic targeting, automated reporting, commercial decision-support use cases, etc.) Experience managing data stewardship process or team Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions. Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees. #J-18808-Ljbffr Xenon Pharmaceuticals Inc.