Postdoctoral Fellow - Next-Gen Sequencing Systems, Research & Early Development

About the Position At Roche, we are developing next-generation sequencing systems to accelerate clinical research, streamline workflows, and broaden access to genomic data. By creating integrated end-to-end solutions, we aim to lower barriers to adoption of DNA sequencing technology. We are seeking a talented and highly motivated Postdoctoral Fellow to join our Systems Technology Group. You will play a major role in the research and early development of new technology, devices, and instruments for next-generation DNA sequencing and molecular diagnostic platforms. Responsibilities Design, fabricate, and assemble custom devices, fixtures, and breadboards using rapid prototyping tools and custom equipment. Develop and implement microfabrication processes, including photolithography, etching, drilling, bonding, and dicing, and use precision metrology instruments to characterize components and evaluate manufacturing methodologies. Create and characterize new materials and bonding methodologies. Test, characterize, and troubleshoot complex fluidic systems and devices; develop and optimize workflows, collect, analyze, and interpret data to advance technical progress. Generate comprehensive test plans, protocols, technical reports, and invention disclosures to document findings and methodology. Select, procure, install, validate, operate, repair, and maintain laboratory/fabrication equipment and custom instrumentation. Required Qualifications Ph.D. in Bioengineering or a closely related discipline with a thesis focused on solving a molecular biology problem through engineering. Solid understanding of physics, engineering, chemistry, molecular biology, and sequencing fundamentals. Demonstrated experience with advanced microfabrication techniques (lithography, thin-film deposition, wet/dry etching, and thermal fusion bonding processes). Success in porting complex biochemical assays or workflows onto novel fluidic systems and optimizing performance using a systematic approach. Strong publication record, including at least one first-authored peer‑reviewed publication in a top-tier journal. Experience with Python scripting for instrument hardware control. Basic knowledge of market trends and peers’ work in the field. Preferred Qualifications Experience designing and testing microfluidic systems with active components and integrated sensors. Experience building, operating, and troubleshooting fixtures or breadboards with fluidic, pneumatic, thermal, and optical subsystems. Proficiency in operating and interpreting data from analytical instruments such as qPCR, dPCR, Bioanalyzer/TapeStation, Qubit, and NanoDrop. High-level perspective with the ability to see the bigger picture and challenge the status quo. Strong teamwork, problem‑solving, judgment, and decision‑making skills, with attention to detail in a fast‑paced environment. Excellent communication skills for interacting with all levels within the organization; hands‑on, self‑directed, organized, and conscientious. Strong time‑management and organizational skills, with the ability to work effectively in a dynamic, continually changing environment. Professional demeanor and ability to establish constructive relationships with colleagues. Benefits & Compensation Salary range for Santa Clara, CA: $100,000 – $106,000 (actual pay determined by experience, qualifications, geographic location, and other factors permitted by law). Location: on‑site in Santa Clara, CA. Relocation benefits are not provided for this role. This position qualifies for the benefits detailed at the link provided in the original posting. Equal Opportunity Statement Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to discrimination on the basis of Protected Veteran status, individuals with disability status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing the accommodations form. Roche is an equal‑opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law. #J-18808-Ljbffr Roche