Director, Clinical Science Oncology Clinical Development (Boston)

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.Find out more:Our approach to R&DOverviewCancer is unrelenting, but so are we. At GSK, we are committed to transforming outcomes for people with cancer through innovative science, bold ambition, and strong partnerships across the healthcare ecosystem. We focus our science where it can matter most—advancing care in cancers with high unmet need, grounded in a deep understanding of disease biology and deliberate scientific choices that connect discovery to meaningful impact in the real world.The Director, Clinical Science – Oncology Clinical Development provides scientific leadership across defined components of study design, conduct, data review, and interpretation within an assigned clinical programme. Reporting to the Clinical Development Lead (CDL), this role operates within the asset-level clinical strategy and contributes scientific depth and rigour to the execution of the Clinical Development Plan (CDP).The Director, Clinical Scientist partners closely with the Senior Scientist and cross-functional teams to support delivery of clinical studies, ensuring scientific quality, data integrity, and robust interpretation of clinical data. This role contributes to both study-level activities and broader programme insights, without holding accountability for asset-level strategy or overall study delivery.This is a scientific individual contributor role requiring deep oncology clinical development expertise, strong analytical and collaboration skills, and the ability to operate effectively within a complex, matrixed environment.Please note: This position requires an on-site office-based presence 2 to 3 days a week in the US (Waltham, MA. or Upper Providence, PA) UK (London or Stevenage); Switzerland (Zug); Poland (Warsaw) or Canada (Mississauga, ON)In This Role You Will:Provide scientific leadership across defined components of study-level activities, including protocol development, study design, data review, and interpretation, within the strategic direction set by the CDLServe as a core member of the Clinical Matrix Team (CMT), ensuring scientific alignment across study objectives, timelines, and deliverablesProvide scientific insight to the CDL and Senior Scientist to inform asset-level strategy, benefit–risk assessment, and programme-level decision-makingEnsure the scientific quality and consistency of key clinical and regulatory documents, including protocols, Investigator’s Brochures, Clinical Study Reports, and submission materialsApply scientific and clinical expertise to analyse and interpret data, ensuring rigour, integrity, and relevance to the target patient populationEngage with internal and external stakeholders, including investigators and Key External Experts, to support study execution and scientific exchangeContribute to a culture of scientific excellence, innovation, and continuous improvement within Oncology Clinical DevelopmentDetailed Responsibilities:Study Design and ExecutionProvide scientific input into protocol development and study design, ensuring robustness, feasibility, and alignment with CDP-defined objectives and regulatory requirementsAuthor or co-author key study documents (e.g., Clinical Study Proposals), contributing to preparation and presentation at governance forums such as Protocol Review BoardsSupport study conduct by addressing scientific questions, ensuring data integrity, and maintaining alignment with protocol and regulatory standardsProvide scientific input into study-level decisions related to protocol implementation and study conduct, within the strategic framework defined by the CDLPresent and support the scientific rationale and study design at Investigator Meetings and respond to scientific inquiries from study sitesSupport implementation of study-level Go/No-Go criteria aligned to the asset-level decision framework defined by the CDLData Generation, Analysis, and InterpretationAnalyse and interpret clinical data to generate insights on safety, efficacy, and patient populationsIntegrate data from internal and external sources (e.g., literature, competitor data, emerging science) to inform study and programme understandingProvide scientific input into data review and interpretation activities, in collaboration with Medical Directors and pharmacovigilanceTranslate study findings into clear scientific insights to inform programme progression and support CDL-led decision-makingClinical and Regulatory DeliverablesContribute to development of clinical and regulatory documents, including protocols, Investigator’s Brochures (IBs), Clinical Study Reports (CSRs), and submission materialsEnsure scientific accuracy, consistency, and quality across study documentationSupport preparation of regulatory submissions and responses to Health Authority queriesContribute to regulatory reporting requirements (e.g., DSURs, INDSRs) and ensure alignment with regulatory standardsCross-Functional Collaboration & Scientific ContributionServe as an extended member of the CMT, partnering with Clinical Operations, Statistics, Safety, Regulatory, and Medical Affairs to support integrated study deliveryProvide scientific expertise to cross-functional discussions, including integrated evidence planning and disease-area forums, as appropriateParticipate in internal and external scientific interactions with investigators, Key External Experts, advisory boards, and collaboratorsContribute to scientific communications, including publications, congress presentations, and study-related materialsWays of Working & Continuous ImprovementIdentify scientific and operational risks at the study level and provide input into mitigation strategiesSupport and drive implementation of consistent ways of working and process improvements across the programmeParticipate in Oncology Clinical Development initiatives and workstreams to strengthen standards, processes, and capabilitiesEngage in ongoing development to deepen scientific expertise, expand disease-area knowledge, and build broader clinical development capabilitiesBasic Qualifications:We are seeking professionals with the following required skills and qualifications to help us achieve our goals:Bachelor’s degree in life sciences or related discipline required5+ years of experience in pharmaceutical/biotechnology industry or related clinical development experience, with a focus on oncology.Experience and understanding of clinical development from early stage through to regulatory submission, including study design, protocol authoring, and data review/interpretation.In-depth knowledge of GCP, ICH, and global regulatory guidelines.Experience authoring or contributing to clinical study proposals, protocols, Investigator’s Brochures, informed consent forms, clinical study reports, and regulatory submissions.Demonstrated ability to operate effectively within cross-functional matrix teams and contribute to clinical decision-making.Proven track record of working with investigators, site staff, external experts, CROs, and vendors.Preferred Qualifications:If you have the following characteristics, it would be a plus:Advanced degree (e.g. MS, PhD, PharmD) strongly preferred in life sciences or a related disciplineClinical development experience across multiple phases of development (Phase I–IV)Oncology or immuno-oncology clinical development experience.Experience presenting or preparing materials for Protocol Review Boards, governance meetings, or scientific forums.Knowledge of regulatory requirements to support registration, including experience contributing to IND, EoP2, scientific advice, pre-NDA/BLA, NDA/MAA, or AdCom submissions.SkillsAnalytical Thinking, Clinical Data Interpretation, Clinical Data Review, Clinical Development, Clinical Trial Designs, Clinical Trials Monitoring, Digital Fluency, Drug Regulatory Affairs, Executive Presence, Hematology and Oncology, Learning Agility, Matrix Leadership, Real World Evidence (RWE), Scientific Presentations• If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $189,750 to $316,250. • If you are based in another US location, the annual base salary range is $189,750 to $316,250. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.Polish Salary Range / Polski przedział wynagrodzenia: PLN 472,500 to PLN 787,500The annual gross base salary range for new hires in this position is listed above for each applicable location. These ranges take into account a number of factors including the candidate’s skills, experience, education level and the market rate for the role. In addition, this position may offer an annual bonus and eligibility to participate i