Senior Manager, Accounting

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale. Our lead product candidate, lysergidetartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges. Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX. Together we are moving psychiatry forward—beyond better, into a boundless future. Join us! Reporting to the Corporate Controller, the Sr. Manager, Accounting will play a key role in our accounting team, with a strong emphasis on SOX 404(b) compliance and equity (stock-based compensation) accounting. This role will be responsible for designing, implementing, and maintaining internal controls, as well as overseeing the accounting and reporting for equity transactions in a fast-paced, public company environment. Responsibilities Oversee accounting for stock-based compensation, including stock options, RSUs, PSUs, and ESPP Ensure accurate and timely recognition of equity compensation expense in accordance with ASC 718 Manage equity-related reports and data from Shareworks Review and validate fair value assumptions (e.g., Black‑Scholes inputs, peer companies) Coordinate with Legal, HR, and external valuation specialists on equity grants and modifications Support preparation of equity disclosures for SEC filings (10‑K, 10‑Q, proxy) Help lead the design, implementation, and ongoing maintenance of internal controls in compliance with SOX 404(b) Partner with internal and external auditors to support control walkthroughs, testing, and remediation efforts Evaluate control deficiencies and drive timely remediation plans Maintain and update process flowcharts, risk control matrices (RCMs), and control documentation Ensure readiness for external auditor attestation under SOX 404(b) Collaborate cross‑functionally to strengthen control environment and ensure adherence to company policies Support month‑end and quarter‑end close processes related to equity and other assigned areas Support commercial‑related initiatives that intersect with equity compensation and SOX controls, including evaluation of control impacts from new or evolving processes Perform other accounting, compliance, and internal control‑related responsibilities as needed to support the company’s financial reporting and growth objectives Qualifications Bachelor’s degree required, degree in Accounting, Finance, or related field preferred, CPA License preferred Minimum 7 years of progressive accounting experience required, life science industry preferred Previous experience with Shareworks and NetSuite preferred Previous experience with equity administration and technical accounting required Previous experience with accounting in a publicly traded company required Experience supporting accounting or SOX considerations related to commercial operations, business process changes, or company scale‑up initiatives preferred Deep, hands‑on knowledge of SOX 404(b) requirements and internal control frameworks (e.g., COSO) Excellent written and verbal communication skills, along with the ability to present numeric data effectively Proven experience working with external auditors in a SOX‑compliant environment Demonstrated ability to handle highly confidential information with sound judgment and discretion Intermediate‑to‑advanced MS Office skills (Outlook, Word, Excel, PowerPoint) Please note that you must come into the San Diego, CA office once a week The starting base pay range for this position is $145,940.00 - $171,503.00. Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location. Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including: 100% paid health benefits including Medical, Dental and Vision for you and your dependents 401(k) program with company match and vesting after the turn of the first month after your start date Flexible time off Generous parental leave and some fun fringe perks! #J-18808-Ljbffr