Senior Scientist, Oligonucleotide

Position Summary Senior Oligonucleotide Scientist (non-viral delivery technical development team). Technical lead for design, synthesis, purification, and analysis of modified oligonucleotides; drive chemical modifications and scale-up process development from discovery through clinical development. Responsibilities Lead automated solid-phase synthesis of complex, highly modified oligonucleotides at various scales. Develop/optimize purification using preparative RP-HPLC, IEX, SEC, plus TFF and lyophilization. Oversee/perform structural elucidation and purity assessments using LC-MS, MALDI-TOF, NMR, and capillary electrophoresis. Optimize synthetic routes and cleavage/deprotection methods to improve yields and reduce impurities. Evaluate/implement novel chemical modifications and conjugation/delivery strategies (e.g., GalNAc, lipids, peptides) to enhance stability and potency. Serve as oligochemistry lead on multidisciplinary teams. Supervise/mentor/train junior chemists and technicians; maintain lab notebooks, write SOPs, support regulatory filings. Manage inventory of testing articles and critical reagents/phosphoramidites. Analyze and communicate results via experimental reports and meetings. Minimum Qualifications Ph.D. (Organic/Medicinal or related) with 4.5–8+ years, incl. 2+ years industrial biopharma/biotech OR non-PhD with 12–15 years progressive experience. Expertise in phosphoramidite chemistry, protecting groups, and nucleotide modifications (e.g., 2'-OMe, 2'-F, phosphorothioates, locked nucleic acids). Hands‑on automated oligonucleotide synthesis (e.g., ÄKTA Oligopilot, Mermade) and preparative purification. Strong troubleshooting and interpretation of LC-MS for complex macromolecules. ICH and cGMP familiarity (highly desirable). Preferred Qualifications Strong problem‑solving; thrive in fast‑paced, matrixed environment. Excellent written/verbal communication. Proven project leadership and collaboration. Compensation & Benefits Base pay range: $145,000–$155,000+ bonus, equity and benefits. On‑site (manufacturing/lab‑based role). #J-18808-Ljbffr Scorpion Therapeutics