Senior Associate Scientist II
$103.5k - $115kScorpion Therapeutics
Duties Manage database and serve as primary liaison for mRNA requests across research and program teams. Independently execute mRNA production at various scales (plate-based high-throughput with automation through lab scale to clinically representative GLP toxicology batches) and provide technical oversight as Person in Plant for GMP manufacturing. Contribute to guide RNA production across sites and scales (research, process scale, GMP). Collaborate with Analytical and QC teams to align testing and release workflows; track and communicate batch status, material availability, and testing timelines. Execute experiments and batch runs to generate IND/BLA supporting data for liver-targeted and partnered programs. Perform statistical/advanced analytics on experimental data; produce graphs for CMC and IND/BLA filings. Plan and execute process improvements and cost-saving initiatives, including raw material evaluation. Perform IVT, capping, and purification (including AKTA-based chromatography); design/support analytical method development. Apply DOE to optimize reaction conditions and interpret results using advanced analytics. Operate automated systems for plate-based mRNA production and sample processing (e.g., Lynx, Big Tuna, ResolveX, Tecan, Hamilton) and train peers. Requirements Bachelor’s degree in Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering, or related field (or foreign equivalent) plus 5 years drug substance process development. 2 years analytical assay development. 4 years enzymatic process development for mRNA production using DoE. 5 years downstream processing with emphasis on chromatography of biologics/RNA (AKTA or similar; scaled down, automated systems). 1 year synthesis/purification of long guide oligonucleotide RNA.
- years high-throughput/automation development, programming, and execution (Tecan/Hamilton/Lynx or similar).
- years analytical characterization (HPLC/UPLC, TEM, DSC, UV-Vis, fluorescence spectrophotometry, plate ELISA).
- years maintaining technically accurate research/experimental records.
Vacancy posted 1 day ago
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