Senior Director, Commercial Forecasting & Artificial Intelligence

Join Immatics and shape the future of cancer immunotherapy; one patient at a time! Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics. Why Join Us?Innovative Environment: Help to pioneer advancements in cancer immunotherapy. Collaborative Culture: Be part of a diverse team dedicated to your professional growth. Global Impact: Contribute to therapies that make a lasting impact on patients globally. Role OverviewWe are seeking a Senior Director, Commercial Forecasting & AI combined role. Approximately half of the position is owning demand, revenue and patient-flow forecasting across Immatics’ portfolio — from early pipeline opportunity assessment through launch readiness and in-line performance. The other half is serving as the Commercial organization’s in-house AI expert: identifying, building and scaling AI and generative-AI capabilities that make a small commercial team perform like a much larger one. The successful candidate is a recognized forecasting expert in oncology or cell and gene therapy who has already put AI to practical, compliant use in a life sciences commercial setting.Reports to:   VP Commercial Analytics & OperationsLocation: Remote U.S.Salary Range: $240,000 – $280,000Basic Qualifications:Bachelor’s or equivalent years of experience15+ years in Life sciences consultancy, biotech, pharma or relatedPreferred Qualifications: 7 Years of Forecasting, Commercial Analytics or market insightsDemonstrated expertise building patient-based and epidemiology-driven forecast models from the ground up for both pre-launch and in-line assets.Deep working knowledge of pharma/biotech data sources and their strengths and limitations — e.g. IQVIA, Symphony Health, Komodo, Definitive Healthcare, specialty distributor and 867/852 data, SEER and other epidemiology sources, clinical registries and syndicated market research.Demonstrated, hands-on experience applying AI and large language models to real commercial problems in a regulated life sciences environment — including practical fluency with LLM platforms, prompt engineering, retrieval-augmented generation and agentic workflows, and a clear-eyed view of where AI does and does not work.Working understanding of the compliance and privacy constraints on AI in life sciences (PHI/HIPAA, GDPR, promotional review, data licensing terms, emerging AI regulation).Advanced Excel modeling plus working proficiency in Python, SQL and a visualization tool (Power BI/Tableau).Experience across the launch lifecycle in oncology, cell and gene therapy, rare disease or another specialty/limited-distribution setting.Proven ability to operate independently in a lean, fast-moving environment, and to translate complex quantitative and technical work into decision-ready recommendations for senior stakeholders.Direct experience forecasting an autologous CAR-T, TCR-T or other engineered cell therapy asset, including site activation and manufacturing-constrained demand models.Track record of standing up a forecasting or commercial AI capability at a pre-commercial or newly commercial company.Exposure to global forecasting and to market access/pricing analytics in specialty oncology.In this role you will:Develop Commercial AI roadmap — Serve as the Commercial team’s resident AI expert across the full commercial organization: partner with Marketing, Market Access, Medical Affairs and Field Operations to identify, prioritize and sequence high-value AI and generative-AI use cases — analytics and forecasting, market research synthesis, competitive intelligence, field enablement, content development and promotional review preparation, account and KOL intelligence, payer and policy monitoring, and CRM data quality — with a clear view of business impact, effort and sequencing.Build the operating systems — Design, build and own AI-powered systems that become how Commercial runs day to day — not one-off pilots. Re-engineer the analytics workflow end to end so recurring work runs itself: automated ingestion and QC of claims, specialty distributor, CRM and third-party data; reconciliation and exception flagging; forecast and dashboard refreshes; self-service analytics layers; recurring report and insight generation; and agentic workflows that take manual assembly off the critical path — shifting the team’s time from producing numbers to interpreting them.Build vs. buy and vendors — Evaluate AI platforms and vendors, run structured pilots against defined success criteria, and make defensible build-versus-buy recommendations.Travel Requirements:10-15%What do we offer?At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect if you join Immatics Comprehensive Benefits:  Competitive rates for Health, Dental, and Vision Insurance 4 weeks of vacation, granted up front each year and prorated for first and last year of employment. 12 company paid holidays 7 days of sick time 100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars 100% employer-paid short- and long-Term disability coverage  401(k) with immediate eligibility and company match. The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment. Partially paid parental leave for eligible employees. Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance. Equal Employment Opportunity We are an equal opportunity employer and are committed to building a diverse and inclusive workplace.  We consider all qualified applicants for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, national origin, ancestry, age, marital status, disability, genetic information, veteran status, or any other status protected by applicable law.   Reasonable Accommodations We are committed to providing reasonable accommodations to individuals with disabilities and to applicants with sincerely held religious beliefs, practices, or observances.  If you require assistance or accommodation during the application or interview process, please contact us at View email address on click.appcast.io.   Work Authorization Applicants must be authorized to work in the United States without the need for current or future sponsorship. Pre-Employment Requirements Employment is contingent upon successful completion of a background check, reference checks and pre-employment drug screening, where permitted by applicable law.  For certain roles, additional screenings such as a credit check or motor vehicle record review may be required, where job-related and consistent with business necessity.   SummaryLocation: Houston; Remote Work (USA)Type: Full time