Senior RNA Chemist - RNA Therapeutics
Amgen Inc
Amgen seeks a Senior RNA Chemist to advance mRNA therapeutic platform technologies in Thousand Oaks, California. The role focuses on mRNA design, synthesis, purification, and characterization to enable next-generation medicine discovery. The chemist will lead experimental efforts, develop platform technologies including chemical modifications and sequence optimization, and collaborate with cross-functional teams to improve RNA stability and manufacturability.
Responsibilities
- Design and implement high-throughput strategies for modular mRNA assembly with therapeutic applications
- Develop mRNA platform technologies including chemical modifications, capping, and sequence optimization
- Lead efforts to improve RNA quality, purity, stability, and biological activity through experimentation
- Develop and apply purification strategies for mRNA using FPLC and related chromatography methods
- Utilize analytical characterization techniques to evaluate impact of modifications on mRNA performance and developability
Requirements
- PhD in chemistry, biochemistry, or related field; or PharmD/MD with postdoc; or Master's with 3+ years relevant experience; or Bachelor's with 5+ years relevant experience
- Expertise in RNA chemistry, oligonucleotide chemistry, or nucleic acid therapeutics
- Hands-on experience with in vitro transcription, RNA purification, and analytical characterization
- Proficiency with analytical methods including HPLC, FPLC, LC-MS, gel electrophoresis, and capillary electrophoresis
- Knowledge of modified nucleotides, capping technologies, and RNA structure-function relationships
- Experience designing and executing experiments independently with strong troubleshooting abilities
- Demonstrated scientific communication through publications, patents, or technology advancement
Vacancy posted 5 days ago
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