Vice President, Commercial Operations (Tumor HI Program)

Rezolute is a late-stage rare disease biopharmaceutical company focused on developing transformative therapies for patients living with severe metabolic and endocrine disorders. Our mission is to bring hope and meaningful solutions to patients and families affected by rare and difficult-to-treat diseases through scientific innovation, collaboration, and integrity.

Rezolute’s lead investigational therapy, RZ358 (ersodetug), is a fully human monoclonal antibody in late-stage clinical development for the treatment of hypoglycemia due to congenital and acquired forms of hyperinsulinism (HI). As Rezolute expands its medical and scientific focus into tumor-related hyperinsulinism (tumor HI), most commonly related to pancreatic neuroendocrine tumors (insulinomas) or paraneoplastic hypoglycemia (NICTH), the company is committed to advancing novel therapeutic strategies that address this rare and complex form of hypoglycemia associated with insulin-secreting tumors and related neuro-oncology disorders.

Position Summary

We are seeking a dynamic and experienced Vice President of Commercial Operations to establish and lead all operational aspects of our commercial strategy in support of the launch of our first rare disease therapy. This includes managing commercial operations functions ensuring the infrastructure, processes, and strategies necessary for successful product launch. This individual will be a strategic and hands-on leader responsible for building and managing critical commercial infrastructure, including sales operations, analytics, forecasting, market access operations, and commercial systems. This role oversees sales operations, forecasting and analytics, incentive compensation, market research, data management, CRM systems, field effectiveness, and commercial training.

The ideal candidate has experience in rare disease or specialty pharmaceutical markets and thrives in an entrepreneurial, fast-paced environment. The ideal candidate has experience in rare disease or specialty pharmaceutical markets and thrives in an entrepreneurial, fast-paced environment.

This role is based in the home office and requires minimum of 3 days per week in the office.

Key Responsibilities

• Serve as a key member of the Commercial Leadership Team, developing and executing commercial strategy and operations plans.
• Develop and execute the commercial operations infrastructure to support a successful rare disease product launch.
• Lead commercial planning processes, including sales forecasting, demand planning, incentive compensation design, and territory alignment.
• Build and oversee a high-functioning sales operations team and associated systems (CRM, data warehousing, reporting dashboards).
• Establish data governance processes and manage third-party vendors providing data (claims, specialty pharmacy, distribution).
• Partner cross-functionally with Market Access, Marketing, Medical Affairs, Finance, and IT to ensure alignment of commercial operations with overall corporate goals.
• Design and manage KPIs and reporting frameworks to track performance and inform commercial decision-making.
• Lead field force enablement efforts, including CRM configuration, targeting, call planning, and field reporting.
• Support the development of compliant policies and processes for commercial activities in collaboration with Legal and Compliance teams.
• Manage operational budgets, contracts, and vendor relationships for commercial functions.

Qualifications:

• Bachelor’s degree required; MBA or advanced degree preferred.
• 12+ years of progressive experience in commercial operations within the biopharmaceutical industry, including at least 5 years in a leadership role.
• Direct experience supporting launch planning and execution for rare disease or specialty products.
• Deep understanding of commercial data sources (e.g., specialty pharmacy, HUB services, patient services, claims data).
• Demonstrated success in building commercial infrastructure in a high-growth or startup environment.
• Strong project management skills, attention to detail, and ability to lead cross-functional initiatives.
• Excellent communication and leadership skills with a collaborative approach.
• Familiarity with compliance regulations in the rare disease space.

Preferred Attributes

• Experience in both pre-commercial and commercial-stage biotech organizations.
• Entrepreneurial mindset and comfort operating in a fast-paced, evolving environment.
• Ability to work in a lean organization with a hands-on, roll-up-your-sleeves style.
• Passion for serving patients with serious or underserved diseases.

Rezolute (RZLT) currently anticipates the base salary for the Vice President of Commercial Operations role could range from $300,000 to 360,000 and will depend, in part, on the successful candidate’s geographical location and their qualifications for the role, including education and experience. This position will also be eligible for an annual performance bonus in accordance with the terms of the applicable plan (depending, in part, on company and individual performance and at the Company’s discretion on an individual basis). The compensation described above is subject to change and could be higher or lower than the range described based on current market survey data and the qualifications, education, experience and geographical location of the selected candidate.

Qualifying employees are eligible to participate in benefit programs such as:

• Health Insurance (Medical / Dental / Vision)
• Disability, Life & Long-Term Care Insurance
• Holiday Pay
• Tracking Free Vacation Program
• 401(k) Plan Match
• Educational Assistance Benefit
• Fitness Center Reimbursement

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.