Senior Scientist, Analytical Chemistry, ADC Technology

Reference: 629450Posted: 2026-09-02Location: Boston, MassachusettsCompany: Planet Pharma GroupContact: ApplicationsEmail: View email address on us.fitly.work SummaryWe are seeking a highly motivated Senior Scientist with expertise in LC-MS-based antibody/protein characterization and/or bioanalytical quantitation to support oncology drug discovery. The successful candidate will perform hands-on analytical research focused on antibody-drug conjugates (ADCs), antibodies, and small molecules using LC-MS and HPLC technologies. This role partners closely with multidisciplinary teams to develop, optimize, and apply analytical methods that support discovery and early development programs.Key ResponsibilitiesPerform analytical characterization and quality control of ADCs, antibodies, and small molecules using LC-MS and HPLC techniques, including: Intact mass analysis, de-glycosylation and reducing LC-MS, Drug-to-antibody ratio (DAR) determination, HPLC methods such as size exclusion chromatography (SEC), hydrophobic interaction chromatography (HIC), and reverse-phase (RP), peptide mapping (a plus).Prepare and analyze samples from purified proteins and biological matrices, including plasma, serum, and tissues.Identify and characterize ADC metabolites from in vitro and in vivo studies using analytical techniques such as affinity capture, forced release, MS/MS, and SIM-MS.Develop, optimize, validate, and troubleshoot analytical methods to improve performance and resolve technical challenges.Operate, maintain, and troubleshoot analytical instrumentation, such as Thermo Vanquish UHPLC-Orbitrap MS, Waters Acquity UPLC-SQD MS, Agilent HPLC, and UV-Vis systems.Evaluate and recommend new analytical technologies and instrumentation to expand internal capabilities.Document experimental work in electronic laboratory notebooks (ELNs), maintain analytical databases, and prepare technical reports and project summaries.Present experimental results and scientific findings to multidisciplinary project teams.Contribute to laboratory operations by maintaining shared equipment, supporting laboratory organization, and improving analytical workflows and efficiencies.QualificationsPh.D. or equivalent degree in Analytical chemistry or a related field with minimum 5 years’ experience, MS degree with 8 years’, or BS degree with 11 years’.Industry experience in analytical chemistry within the biopharmaceutical or pharmaceutical industry.Hands-on experience with protein and bioconjugate characterization using LC-MS, UV-Vis, and HPLC.Experience with protein sample preparation techniques, including de-glycosylation, reduction, and enzymatic digestions of ADCs.Working knowledge of chromatographic methods, including SEC, HIC, and reverse-phase HPLC.Experience operating, maintaining, and troubleshooting LC-MS and HPLC instrumentation.Strong analytical and problem-solving skills with excellent attention to detail.Ability to manage multiple priorities and work independently in a fast-paced environment.Excellent written and verbal communication skills, with the ability to present scientific data to multidisciplinary teams.Demonstrated ability to collaborate effectively with cross-functional teams, including chemists, protein engineers, and biologists.Scientific curiosity, a passion for innovation, and enthusiasm for evaluating and implementing emerging analytical technologies.A publication record in peer-reviewed scientific journals is desirable.