Associate Director, Operational Excellence

Associate Director, Operational Excellence

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

The Operational Excellence and Training Lead enables scalable, efficient, and inspection-ready execution across Development by designing standardized processes, building operational capabilities through training, and driving consistent adoption and continuous improvement.
Your Role:

• Own and lead end-to-end design, implementation, and optimization of assigned process and system across Development
• Translate strategic objectives into fit-for-purpose, standardized processes that are efficient, scalable, and inspection-ready
• Define process standards, guidance, and performance measures, ensuring clarity of roles and accountability
• Develop and deliver training on new/changed processes incl. compliance expectations, and inspection readiness behavior
• Design and maintain role-based and process-based curricula, including onboarding
• Identify inefficiencies, risks, and variability through data analysis and stakeholder input, and lead targeted improvement initiatives
• Support functions in adopting new or improved processes through change management, training inputs, and practical guidance
• Ensure processes are well documented, consistently applied, and auditable, supporting inspection readiness
• Track and report process performance, improvement outcomes, and residual risks to Operational Excellence & Clinical Compliance leadership
• Act as a subject‑matter expert and trusted advisor to functional teams on process excellence and operational rigor
• Support Leadership in defining and executing the learning and capability‑building strategy for Development functions
• Support leadership in building a learning culture that reinforces accountability, consistency, and continuous improvement

What You Bring:

Required Qualifications

• Bachelor’s degree required (Life Sciences, or related field)
• Advanced degree preferred (e.g., MBA, MSc)
• Certification or formal training in Operational Excellence, Lean, Six Sigma, or Process Improvement preferred

Required Experience

• 8–10+ years’ experience in operational excellence, process improvement, training, or operational leadership within a regulated life sciences or clinical development environment
• Proven experience owning and implementing end-to-end processes or systems across multiple functions
• Hands‑on experience designing and delivering process and role-based training
• Experience supporting audit and inspection readiness, including documentation and behavioral readiness
• End-to-end process design, standardization, and optimization
• Training design, curriculum development, and adult learning principles
• Process documentation (SOPs, guidance, work instructions)
• Process performance metrics, KPIs, and dashboarding
• Understanding compliance and inspection expectations in regulated environments.
• Strong systems thinker able to translate strategy into execution
• Excellent facilitation, communication, and stakeholder‑engagement skills
• Ability to influence and drive adoption without direct authority
• Pragmatic change leader with strong execution discipline
• Trusted advisor mindset with high credibility and accountability
• Collaborative, service‑oriented, and improvement‑focused

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range

$164,000 - $246,000 USD

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Tango Therapeutics’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA.Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

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