Principal Scientist

Job Description

Job Description

Join a company where your science will directly shape the future of cancer immunotherapy

Who We Are

EvolveImmune Therapeutics is a privately-held, next-generation immuno-oncology company pioneering a new class of T cell engager therapies to transform cancer patient outcomes compared to current immunotherapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell costimulation to directly target tumor cells to deliver durable anti-tumor adaptive immune responses. Our lead asset, EVOLVE104, entered clinical trials in late 2025. Additional collaboration pipeline programs (with Abbvie) and wholly owned programs are progressing toward candidate nomination. EvolveImmune’s team consists of ~50 FTEs in R&D, business development, people & culture, finance and operations. Our newly expanded, state-of-the-art 20,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor is convenient to the amenities of the Connecticut shoreline, the city of New Haven and easy travel options throughout the Boston/New York City corridor.

We’re hiring a Principal Scientist to join our collaborative Translational Sciences team focused on designing and advancing first-in-class immune-engaging biologics. This is a hands-on, lab-based role where your contributions directly shape the next generation of immunotherapy.

We value curiosity, collaboration, and diverse perspectives—if you’re excited by our mission but unsure if you meet every requirement, we encourage you to apply.

What You’ll Work on

In this role you will execute translational immunology research to support IND enabling activities and phase I clinical studies in oncology. Experience in immune-assay development and expertise in human immunology and T cell immunobiology are required. The role involves experimental design (CRO and internal) and execution (bench work) as well as interpretation and presentation of results. This is an exciting opportunity for a highly collaborative and creative scientist who is eager to position novel immunotherapies in the cancer immunology treatment landscape. Close collaboration and matrix working with members of the Immunobiology, Biotherapeutics and Translational Sciences teams are expected. Evidence for a track record of scientific and/or project achievements is preferred. 

• Design and conduct in vitro studies with an emphasis on immunological testing of human and animal samples using state-of-the-art techniques including immune cell functional assays, multi-parameter FACS including BD and Cytek instruments, cell separation, multiplex assays, cell toxicity, proliferation
• Perform immune-monitoring related experiments of mouse and clinical samples (tumor, whole blood, PBMC, sera, etc.) 
• Provide scientific input to optimize project progression 
• Maintain records of experiments in electronic notebooks, analyze data and prepare presentations 
• Deliver clear, concise presentations at portfolio and project meetings to enable organizational alignment
• Support the authoring of essential internal and regulatory documents
• Partner with Immunobiology, Biotherapeutics and Translational Science teams to ensure proactive sharing of scientific know-how across the organization
• Ensure compliance with all health and safety protocols

What You Bring

• PhD in immunology or a related fields with 5+ years of postdoctoral and/or industry experience

• Patient focused - dedication to enabling translation of preclinical research into impactful human therapies 

• Proven track record in cellular immunology in translational setting demonstrating technical expertise in immune assays and primary cell cultures
• Experience in the field of immune-oncology and large data analytics is a plus
• Capable of clarifying problems and working in collaboration with team members to identify solutions
• Strong verbal and written communication skills

What You’ll Gain

• A high-impact opportunity to help advance novel biologic therapies targeting solid tumors
• Mentorship and guidance to support your professional growth in translational immunology and drug development
• Exposure to integrated drug discovery across immunobiology, protein engineering, in vivo models, and translational research
• A mission-driven environment where your contributions matter and discovery meets real-world impact

Why You’ll Love Working Here

• Direct impact: Your science will influence platform design and shape next-generation clinical programs.
• Cutting-edge science: Help pioneer new approaches to T cell redirection in solid tumors.
• Personal growth: Gain exposure to every stage of early discovery in a collaborative biotech setting.
• Collaborative culture : Join a supportive, curious, and driven team aligned around scientific innovation and patient outcomes.
• Top-tier facilities : Work in a brand-new, purpose-built lab and office space near New Haven, CT.
• Mission with meaning : Join a company working to give more patients real hope in the fight against cancer.

Additional Info 

• This is a full-time, onsite position based in Branford, CT
• We offer competitive salary, benefits, equity, and paid time off
• We are an equal opportunity employer and value diverse perspectives in all aspects of our work
• Learn more about our science and our team at

Wage Posting

The anticipated base salary range for this position is $119,000 to $145,000, depending on job-related factors such as experience, education level, skills, and location. This range is based on a full-time position.

Benefits Statement

In addition to base salary, this role is eligible for annual performance or discretionary incentive compensation. EvolveImmune Therapeutics, Inc. also offers a competitive benefits package, including but not limited to medical, dental, vision, parental leave, 4 weeks of paid time off, paid holidays, cellphone reimbursement, a 401(k) plan with employee and company contribution opportunities, employer-provided life insurance, and disability.