Senior Principal Scientist, LC‑MS & RNA Therapeutics
BioSpace
Lilly, together with Orna Therapeutics, Inc., a Lilly subsidiary based in Watertown, MA, is seeking a Senior Principal Scientist to drive analytical characterization of circular RNA and lipid nanoparticle‑based therapeutics using LC‑MS/MS. You will partner with Platform Science, Discovery, and CMC to advance method development and product characterization in a fast‑paced, collaborative environment. This role requires leadership in LC‑MS assay development, method qualification, and data #J-18808-Ljbffr BioSpace
- Lilly is seeking a Senior Principal Scientist to drive analytical characterization of circular RNA and lipid nanoparticle-based therapeutics with a focus on mass spectrometry. The candidate will develop and qualify LC-MS/MS assays and lead method transfer to partners in...PrincipalSenior
- Orna Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company, seeks a Senior Principal Scientist to drive analytical characterization of circular RNA and LNP-based therapeutics, focusing on LC‑MS/MS methods and cross‑functional collaboration in a fast-paced...PrincipalSenior
$71.25k - $187k
...philanthropy and volunteerism. Orna Therapeutics, Inc., a wholly owned... ...our pioneering circular RNA technology, developed at MIT... ...are seeking an exceptional Senior Principal Scientist to join our growing team.... ...extensive prior experience in LC‑MS/MS analysis of biologics,...PrincipalSeniorFull timeH1bVisa sponsorshipWork visaFlexible hours- Novartis Group Companies is seeking a Senior Scientist II in Cambridge, MA, to join their Translational Medicine Drug Disposition Discovery... ...support for drug discovery projects and requires strong skills in LC-MS methodology and custom method development. The ideal...Senior
$115k - $215k
...inaccessible with conventional therapeutics. Having advanced the... ...mass spectrometry (MS) assays using state-of-the-art LC-MS systems—including nano... ...recommendations to project teams, senior leadership, and external... ..., solutions-oriented scientist with the ability to manage...PrincipalSenior$179k - $236k
...accomplished DMPK and bioanalytical scientist with experience in PK study... ...medicine, or nucleic acid / RNA therapeuticsFamiliarity with... ...stage biotechExperience with LC-MS/MS or related mass... ...indications. The company’s initial therapeutic programs are designed to restore...PrincipalSenior$98.7k - $183.3k
Novartis is seeking a Senior Scientist II at their Cambridge location. This role focuses on high-quality bioanalytical support for drug discovery... ...and mentorship. A proven biopharma background and LC-MS expertise are essential. The position offers a competitive salary...Senior$45k
...Waltham, MA The Company We are Alloy Therapeutics - a biotechnology ecosystem company... ...drug discovery community from academic scientists, small and medium biotech, to the largest... ...hands-on scientist with strong expertise in LC–MS to lead bioanalytical characterization...SeniorApprenticeshipWork at officeImmediate startFlexible hours$117k - $158.2k
Overview: The Scientist, Analytical Sciences will be a key team member... ...impurity characterization of siRNA therapeutics. They will have direct... ...working knowledge of HPLC and MS fundamentals in support of troubleshooting... ...with oligonucleotide based LC-assay method development,...Full timeContract workTemporary workLocal areaFlexible hours- We are seeking a Senior Principal Scientist to join the US Neuromuscular group based in Cambridge, MA and... ...early drug discovery across multiple therapeutic programs and target discovery efforts.... ...Requirements PhD with 15+ years or MS Degree with 20+ years in drug discovery...PrincipalSeniorLocal area
- ...Description The Immunology Discovery Therapeutic Area is seeking an accomplished and experienced Scientist to lead the Immune Cell... ...with direct reports, peers, and senior leadership Establish and manage... ...Qualifications 18 + (BS), 16 + (MS), or 10 + (PhD) years of...PrincipalSeniorWork experience placement
$109k - $143k
Tessera Therapeutics is seeking a highly motivated Bioanalytical Scientist in Somerville, Massachusetts. The candidate will develop and validate LC-MS methods to characterize proteins, oligos, and lipids to support therapeutic programs. The role offers a salary range of...- ...Pharmaceuticals in Cambridge, MA is seeking a Metabolomics Scientist to join the Translational Research group. The role emphasizes LC-MS/MS based omics, biomarker discovery, and pharmacodynamic studies for RNAi therapeutics. The successful candidate will design methods for...
$109k - $143k
...experience is a plus. Hands‑on experience in LC‑MS based bioanalysis of proteins, oligos or... ...a highly motivated bioanalytical scientist to fulfill a Scientist role in our DMPK... ...and clinical programs for a variety of therapeutic indications. The ideal candidate must have...Local area- ...Job Description About Synolo Therapeutics: Synolo Therapeutics, an... ...is seeking an experienced Principal Scientist to help establish and advance... ...to multidisciplinary teams, senior leadership, and external collaborators... ...CE-SDS, icIEF, AC-SINS, and LC-MS (e.g., intact mass, peptide...PrincipalSeniorLocal area
- Noara Therapeutics, Cambridge, MA, is seeking a Senior Scientist or Scientist with deep expertise in cell biology, immunology, and assay development to lead the... ...biology, automation, and data science teams to develop scalable assays for our RNA‑LNP #J-18808-Ljbffr C10 LabsSenior
- Kymera Therapeutics is seeking a scientific leader to drive targeted proteomics programs across discovery and preclinical studies. You will design and execute MS-based assays, collaborate with cross-functional teams, and influence program decisions with data. The role...Senior
$126k - $234k
Job Description Summary#LI-Hybrid Internal Title: Principal Scientist II or Senior Principal ScientistLocation: Cambridge, MANovartis is a leader... ...translational modeler eager to accelerate oligonucleotide therapeutics (xRNA”), including antibody-xRNA conjugates, from...PrincipalSeniorFull time$148.5k - $214.5k
Job title: Senior Principal ScientistLocation: Cambridge, MAAbout the JobWe are seeking a highly motivated Senior Principal Scientist to spearhead the execution and expansion of our mast cell... ...and best-in-class rare disease therapeutics.Initiate and lead new preclinical...PrincipalSeniorFull time$143k - $214.5k
...biotechnology company developing innovative RNA-based products to address global... ...are seeking an innovative and strategic Principal Scientist, Molecular Cloning Technologies to lead... ...strategy, findings, and recommendations to senior leadership. PROFESSIONAL EXPERIENCE &...PrincipalSenior$148.5k - $214.5k
Job title: Senior Principal Scientist/Principal Scientist, Real-World Evidence & Disease GenomicsLocation: Cambridge, MAAbout the JobJoin Sanofi... ...future of drug discovery and development across Sanofi's therapeutic areas — from early indication prioritization to business...PrincipalSeniorFull time$148k - $203.5k
...are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the... ...Medicines is seeking an accomplished and highly collaborative Senior Principal Scientist, In Vitro Pharmacology to lead the development and...PrincipalSenior$119.7k - $222.3k
...potentially includes small molecules, biologics/therapeutic proteins, antibody drug-conjugates,... ...development, or in AI strategy, to be considered for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist.Extensive and in-depth...PrincipalSeniorFull time- ...Summary These are Associate Scientist and Senior Scientist roles in the... ...as a bench scientist to help Principal Investigator for clients’ projects... ...Education & Experience BS/MS/PhD. with 0-5 years discovery... ...Binding assays, Hybridization LC-Fluorescence assays, RT-qPCR...Senior
$138.6k - $257.4k
...Novartis Biomedical Research is seeking an accomplished Imaging Scientist to join the Image Analysis team in Cambridge.This role is for a... ...capabilities required to perform the role at the offered level.PhD or MS in biology, bioinformatics, biomedical engineering,...PrincipalSeniorFull time$120k - $160k
...part of that team. Job Summary The QC Senior/Principal Scientist for Analytical Method Validation is a... ...quality attribute methods relevant to gene therapeutic product (e.g. cell function... ...Education, Certifications, Licenses Ph.D or MS in Molecular Biology/Biochemistry or other...PrincipalSeniorImmediate startVisa sponsorship- Moderna Therapeutics in Cambridge, MA, seeks a Senior Research Associate to advance RNA modification biology within the RNA Innovation team. This lab-based role focuses on designing experiments to understand how RNA modifications affect RNA metabolism and performance. The...Senior
$127k - $141k
...portfolio of investigational therapeutic programs organized around our... ...a talented, highly motivated Scientist I with expertise in oligonucleotide... ...-on experience in long guide RNA synthesis, chemical... ...oligonucleotides using UPLC, LC-MS (Orbitrap), UV spectroscopy,...Full timeTemporary workFor contractors$108.5k - $201.5k
...Description Summary#LI-OnsiteInternal job title: Principal Scientist ILocation: Cambridge, United StatesWe... ...assays, with a focus on immunoassay and LC-MS based methods supporting neuromuscular... ...other multi-omics approaches, including RNA-seq or related platforms.Strong...PrincipalFull time$119.7k - $222.3k
...potentially includes small molecules, biologics/therapeutic proteins, antibody drug-conjugates,... ...development, or in AI strategy, to be considered for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist. ~ Extensive and in-...PrincipalSenior
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