Senior Scientist, Targeted Delivery Biology

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it. The Cell Therapy Thematic Research Center is one of BMS’s differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. More specifically, our discovery and translational scientists are focused on developing next‑generation, engineered cell‑based therapies. The team is committed to discovering and developing transformative therapies that harness the power of the immune system to improve patient outcomes. Position Summary We are seeking a highly motivated and collaborative Senior Scientist, Targeted Delivery Biology to join BMS's Non‑Viral Delivery team and help define the next frontier in targeted delivery biology at an exciting inflection point in the field. As part of a dynamic and cross‑functional team, you will drive the mechanistic understanding and biological optimization of targeted nanoparticle delivery systems, pushing the boundaries of selective and efficient delivery to unlock therapeutic access into new cell types and tissues. This role sits at the intersection of cell biology, receptor biology, and delivery sciences, representing a rare opportunity to contribute foundationally to a growing platform and work at the cutting edge of non‑viral delivery biology to help shape the next generation of targeted therapeutics. The ideal candidate brings deep scientific curiosity, a passion for solving complex delivery challenges, and thrives in a fast‑paced, highly collaborative research environment. Position Responsibilities Design and apply mechanistic and functional assays to interrogate nanoparticle delivery across key biological barriers, from cellular uptake and endosomal escape to functional payload activity, and translate findings into actionable design principles that guide nanoparticle optimization and next-generation delivery strategies. Establish cell-based approaches to identify and validate receptors for targeted delivery, investigating key receptor properties, including expression, accessibility, internalization kinetics, and trafficking, to optimize delivery efficiency and selectivity. Contribute to internal and external efforts in receptor identification and targeting ligand discovery and development to enable targeted delivery into new cell types and tissues. Develop and apply in vitro safety and biocompatibility assays to characterize biological responses to nanoparticle delivery systems and support early identification and mitigation of delivery-related liabilities. Contribute to the evaluation and assessment of emerging delivery technologies, applying delivery-relevant biological and functional criteria to support platform and lead selection decisions. Collaborate effectively across multidisciplinary teams, including formulation and delivery sciences, protein engineering, analytical development, and pharmacology, to translate biological insights into improved delivery platform design. Effectively communicate scientific findings and actionable recommendations to multidisciplinary teams and leadership to influence delivery strategy and program decisions. Provide scientific mentorship to junior scientists and contribute to the development of new experimental approaches and technologies. Basic Qualifications Bachelor’s Degree 7+ years of academic and / or industry experience Master’s Degree 5+ years of academic and / or industry experience Ph.D. or equivalent advanced degree in the Life Sciences 2+ of academic and / or industry experience Preferred Qualifications PhD in Cell Biology, Molecular Biology, Immunology, Biochemistry, Bioengineering, Pharmaceutical Sciences, or a related discipline with 2+ years of relevant industry experience; or MS with 5+ years; or BS with 7+ years of relevant experience. Strong background in cell biology and quantitative cell-based assay development, with demonstrated ability to design and apply experiments to address mechanistic biological questions. Strong understanding of receptor-mediated delivery, including the key properties that influence productive cellular uptake and delivery. Experience developing and applying quantitative and functional cell-based assays across a range of imaging, flow cytometry, molecular biology, and biochemical methods. Experience with nanoparticles, lipid nanoparticles, liposomes, extracellular vesicles, biologics, nucleic acid delivery systems, antibody-drug conjugates, or other complex delivery modalities is preferred. Demonstrated ability to work effectively in multidisciplinary teams and thrive in a highly collaborative, cross-functional research environment. Strong scientific communication skills, with the ability to present complex data and mechanistic insights clearly and compellingly to varied audiences including project teams and senior leadership. Compensation Overview Cambridge - MA - US: $142,220 - $172,340 The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance. Benefits wellbeing support retirement and financial protection benefits insurance offerings (medical, dental, vision, life and disability) Flexible Time Off (FTO) for U.S.-based exempt employees 11 paid company holidays each year for exempt employees 160 hours paid vacation annually for new hires (subject to manager approval) for non-exempt employees, RayzeBio employees, and employees located in Puerto Rico 11 paid company holidays for those employees 3 optional holidays for those employees paid sick leave up to two paid volunteer days per year summer hours flexibility leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs annual Global Shutdown between Christmas Day and New Year's Day How We Work Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site‑essential, site‑by‑design, field‑based and remote‑by‑design. The model assigned to this role is based on its core responsibilities. Learn more at Supporting People with Disabilities BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to View email address on click.appcast.io. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. Candidate Rights BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Data Protection We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. R1607127 : Senior Scientist, Targeted Delivery Biology Data Privacy Link We’re creating innovative medicines for patients fighting serious diseases. We’re also nurturing our own diverse team with inspiring work and challenging career options. No matter the role, each one of us makes a contribution. And that makes all the difference. #J-18808-Ljbffr Bristol-Myers Squibb Co