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Associate Scientist, Formulation Development

$106k - $138k

Denali Therapeutics Inc

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Salary Range: $106,000.00 to $138,000.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Key Accountabilities/Core Job Responsibilities Support formulation and drug product development activities for one or more of Denali’s large molecule biotherapeutics. Execute formulation development studies to identify clinical formulations and dosage forms. Perform hands‑on characterization of protein therapeutics using chromatography, capillary electrophoresis, and spectroscopy‑based analytical methods. Develop understanding of key degradation mechanisms for each therapeutic. Conduct clinical in‑use compatibility studies. Support drug product process development activities including lyophilization. Translate analytical results into robust, stable formulations ensuring product quality. Author technical documents including formulation development reports and stability protocols/reports. Maintain accurate and timely experiment records in electronic laboratory notebook (ELN). Contribute to establishing state‑of-the‑art formulation capabilities. Present experimental results in team meetings. Qualifications/Skills BS or MS in Biochemistry, Chemical/Biochemical Engineering, Pharmaceutical Sciences, or related scientific discipline with 2+ years of relevant CMC experience in biotech/pharma. Experience in formulation development, compatibility, stability studies, and buffer exchange. Experience with high‑concentration protein formulations and/or lyophilization preferred. Hands‑on experience with chromatography, capillary electrophoresis, spectroscopy, or particle analysis methods. Strong collaboration and teamwork skills. Ability to manage priorities in a fast‑paced environment. Excellent laboratory, critical thinking, scientific problem‑solving, and organizational skills. Excellent spoken and written communication skills. Motivated, detail‑oriented, naturally curious individual with a creative approach to scientific problem solving. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class. #J-18808-Ljbffr Denali Therapeutics Inc

Vacancy posted 4 days ago
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