Postdoctoral Fellow

Department/Area: Molecular and Cellular Biology / Applied Physics / SEAS

Position Description

Our lab is developing a series of cutting‑edge methods to visualize cellular organization. As one example, we are using time‑resolved cryo‑vitrification (both cryo‑plunging and high‑pressure freezing) to visualize the nanoscale dynamics of cellular response to stimuli. In another direction, we are developing multicolor electron microscopy using the principle of “cathodoluminescence” – emission of light triggered by excitation with an electron beam. The advertised position involves further development of these and related methods as well as applications of these new technologies to address questions in the fundamental cell biology of transmembrane signaling through G‑protein‑coupled receptors and the formation of biomolecular condensates.

Basic Qualifications

• Biophysical instrumentation development: optical and mechanical design, simulation, development and control
• Optical imaging; Single‑molecule fluorescence and FRET; Lasers; Pump‑probe experiments
• Biophysics of cell signaling and stress response; Biomolecular condensates; G‑protein‑coupled receptors (GPCRs); Cell and molecular biology
• Cryo‑vitrification via cryo‑plunging and high‑pressure freezing; Time‑resolved freezing
• Microfluidics; design, simulation, prototyping, fabrication and testing of fluidic devices
• Electron microscopy (cryo and regular) for structural and cell biology; Cathodoluminescence

EEO/Non‑Discrimination Commitment Statement

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