Associate Scientist, Postdoctoral Research Fellow, AI-Guided Functional Immunology
$82k - $92kFull-time
Merck
Job Description Postdoctoral Research Fellow, AI-Guided Functional Immunolog y
Our AI/ML team develops biologically grounded and interpretable machine learning methods to accelerate target discovery across immunology. We are seeking a highly motivated Postdoctoral Research Fellow to develop next-generation perturbation modeling approaches that integrate single-cell transcriptomics, functional genomics, and human organoid models to elucidate immunological disease mechanisms and generate experimentally validated biological insightsf. What You'll Do:
Biology, Computational Biology, Data Analysis, Design of Experiments (DOE), Image Analysis, Immunology Research, Programming Languages, Single-Cell Genomics, Statistical Analysis Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.- Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
Yes Travel Requirements:
10% Flexible Work Arrangements:
Hybrid Shift:
Not Indicated Valid Driving License:
No Hazardous Material(s):
N/A Job Posting End Date:
10/19/2026
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R420884
Our AI/ML team develops biologically grounded and interpretable machine learning methods to accelerate target discovery across immunology. We are seeking a highly motivated Postdoctoral Research Fellow to develop next-generation perturbation modeling approaches that integrate single-cell transcriptomics, functional genomics, and human organoid models to elucidate immunological disease mechanisms and generate experimentally validated biological insightsf. What You'll Do:
- Advance AI/ML methods that connect single-cell foundation models with functional perturbation data.
- Develop interpretable and reproducible computational approaches to predict how genetic and chemical perturbation of immune cells reshape cell states.
- Design and interpret perturbation designs together with experimental groups and feed the resulting data back into the models.
- Develop experiment-selection strategies (active learning, Bayesian optimization) that decide which knockouts the next round tests and characterize how a model-chosen training set biases its own evaluation.
- Design evaluations for out-of-distribution generalization held-out cell contexts, matched-decoy nulls, and the linear and mean baselines a foundation model must beat to earn trust.
- Collaborate with multidisciplinary teams across data science, immunology, functional genomics, and translational research.
- Communicate scientific findings through presentations, publications, and cross-functional discussions.
- Strong expertise in machine learning, deep learning, and data science.
- Demonstrated research productivity through publications, preprints, or conference presentations.
- Ability to communicate complex technical concepts to multidisciplinary scientific teams.
- Must currently hold a PhD OR
- Receive a Ph.D. no later than spring 2027
- Ph.D. in Computational Biology, Bioinformatics, AI/ML, Computer Science, Immunology, Bioengineering, Statistics, or a related quantitative discipline
- Experience with single-cell omics analysis, representation learning, or biomedical data analysis.
- Strong expertise in machine learning, deep learning, and data science.
- Proficiency in Python and deep learning frameworks such as PyTorch.
- Experience applying and evaluating deep models on high-dimensional biological data (single-cell, imaging, or similar).
- Proficiency in Foundation Models, Perturbation Modeling, and/or Organoid Models.
- Experience with CRISPR and target discovery.
- Single-cell foundation models, transformers, and representation learning.
- Genetic perturbation modeling: CRISPR screens, Perturb-seq, or arrayed knockouts.
- Wet-lab experience, especially involving organoid, iPSC, or immune co-culture model systems.
- Background understanding of, or experience working in, immunology.
- Experimental design, active learning, or model benchmarking and evaluation.
- Publications in venues such as NeurIPS, ICML, ISMB/RECOMB, Cell Systems, Nature Methods, or related journals.
Biology, Computational Biology, Data Analysis, Design of Experiments (DOE), Image Analysis, Immunology Research, Programming Languages, Single-Cell Genomics, Statistical Analysis Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.- Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
Yes Travel Requirements:
10% Flexible Work Arrangements:
Hybrid Shift:
Not Indicated Valid Driving License:
No Hazardous Material(s):
N/A Job Posting End Date:
10/19/2026
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R420884
Vacancy posted 2 days ago
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