ViiV Healthcare (GSK) Director, Nonclinical Drug Discovery Modeling and Programming (Branford)

ViiV Healthcare is a global specialty HIV company, the only one that is 100% focused on researching and delivering new medicines for people living with, and at risk of, HIV. ViiV is highly mission-driven in our unrelenting commitment to being a trusted partner for all people living with and affected by HIV. Our aim is to think, act, and connect differently through a focus on education and treatment for HIV. We go to extraordinary lengths to deliver the sorts of breakthroughs, both in treatments, care solutions and communities, that really count and take a holistic approach to HIV through developing and supporting sustainable community programs and improving access to care. We are fully committed to push through every challenge until HIV/AIDS is eradicated. ViiV has played a significant part in delivering breakthroughs that have turned HIV into a manageable health condition. We offer the largest portfolio of HIV medicines available anywhere, and we continue our work to cater for the widest possible range of needs in response to the HIV epidemic.We are aware of how much is at stake for those affected by HIV and we show up 100% committed to the patients every day. Our work culture is fast-paced, diverse, inclusive, competitive, and caring. But ViiV isn’t just somewhere to work – it’s a place to belong, an invitation to bring your very best, and a team full of impact-driven team members who are hungry to make a difference.While we have been improving lives of HIV patients for 30 years, this is an especially exciting time to be at ViiV, as we evaluate novel approaches to treatment and prevention that could further reduce the impact of HIV on individuals and communities.The Director, Nonclinical Drug Discovery Modeling and Programming serves as the scientific and strategic lead for Model-Informed Drug Discovery (MIDD) within ViiV Discovery, driving the application of predictive modeling, simulation, and computational tools to inform portfolio decisions across HIV programs. This predominantly discovery-focused role partners closely with DMPK, Medicinal Chemistry, Biology, and Clinical Pharmacology to enable early dose predictions and guide the design and selection of high-quality clinical candidates as rapidly as possible. Leveraging expertise in PBPK, IVIVE, PK/PD, formulation and route-of-administration modeling, the role develops fit-for-purpose modeling approaches and scalable tools that accelerate decision-making from target validation through candidate selection and into early clinical development for multiple modalities (e.g. SM, Biologic, ADC, LNP, PROTACs). The Director is accountable for advancing ViiV's discovery modeling strategy and translating complex ADME, pharmacokinetic, pharmacological, and translational data into actionable insights that improve candidate quality, dose prediction, and development success.This role will be based out of Branford, CT & is eligible for a domestic relocation package.This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:Develop and apply fit-for-purpose mechanistic and translational models (PBPK, IVIVE, PK/PD) to guide design teams toward the highest-quality clinical candidates.Build scalable computational tools, workflows, and prototypes that accelerate discovery decisions and candidate optimization.Apply modeling expertise across diverse modalities, formulations, and routes of administration, including long-acting therapies.Drive innovation through advanced modeling, AI/ML approaches, and emerging external scientific developments.Establish best practices, standards, and governance for modeling methodologies, tools, and computational workflows.Translate complex ADME, PK, PD, and translational data into actionable insights for project teams and senior leadership.Lead cross-functional collaboration across Discovery DMPK, Discovery Pharmaceutics, Clinical Pharmacology, and Nonclinical Safety to enable rapid, data-driven decisions.Build organizational capability in modeling, simulation, programming, and prototyping through mentoring and scientific leadership.Represent ViiV externally through scientific publications, regulatory interactions, and thought leadership activities.Why You?Basic QualificationWe are looking for professionals with these required skills to achieve our goals:MS Degree & 12 years or PhD & 8 plus years of experience (post-graduation) in drug discoveryAdvanced computational programming expertise in model scripting languages (e.g., R, Python, or equivalent) and modeling platforms (e.g., SimCYP, GastroPlus, WinNonLin, etc.) to develop modeling and analysis workflowsDevelopment of scalable, reproducible modeling frameworks, including version control, modular code structures, and automated workflows for simulation and data integrationExperience in the application of empirical (e.g. NCA, compartmental modeling) and mechanistic modeling (e.g. PBPK, QSP) approaches to support discovery programs and rapid decisionsExperience integrating diverse datasets (in vitro, in vivo, clinical, omics where applicable) into unified predictive modeling platformsApplication of frequentist, Bayesian, and/or AI/ML approaches (e.g., surrogate modeling, parameter optimization, predictive analytics) to enhance model performance and decision-makingSoftware/tool evaluation and implementation, including external vendor platforms and internally developed tools, with accountability for scientific rigor and fit-for-purpose useAbility to interpret and communicate modeling results to senior stakeholders, cross-functional teams, and through reports and literature articlesPreferred QualificationIf you have the following characteristics, it would be a plusPhD with 12 plus years of drug discovery experienceExperience working across teams, including matrix and functional leadership, and partnering with internal and external expertsExcellent written, verbal, and presentation skills, including experience communicating scientific concepts to cross-functional teams and stakeholders.Experience in infectious disease and/or immunology therapy areas#LI-ViiV#LI-GSKPlease visit GSK US Benefits Summaryto learn more about the comprehensive benefits program ViiV offers US employees. All ViiV employees receive the same benefits options and plans as GSK employee.Why Us?At ViiV Healthcare, we will not rest until we leave no person living with HIV behind. Until the 40 million people living with HIV is down to zero, we will continue searching for new ways to limit the impact of HIV. We are the only pharmaceutical company solely focused on combating, preventing, and ultimately eradicating HIV and AIDS. At ViiV Healthcare, we do things differently. Born out of a partnership between GSK and Pfizer in 2009, with Shionogi joining in 2012, we are determined to help end the HIV epidemic. We are guided by our mission to leave no person living with HIV behind and it is this mission that unites our employees located across the globe. We combine expertise in research, manufacturing, policy and more to push the boundaries of what people think is possible in HIV treatment and care. As a result of our connection with GSK, we are able to draw on their proud history and resources. This means that you would receive all the employee benefits offered by GSK.Living our mission of leaving no person living with HIV behind means keeping inclusion and diversity at the heart of everything we do - from our breakthrough innovation, to our diverse portfolio of medicines as well as the work we do to partner with HIV communities. Having a truly inclusive culture where we’re all able to be ourselves and feel like we belong will make us an even stronger team, better able to perform as a business and deliver on our mission to leave no person living with HIV behind.If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - View email address on apply.placed-app.com is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.Important notice to Employment businesses/ AgenciesViiV does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact ViiV's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to ViiV. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and ViiV. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ViiV. ViiV shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, ViiV may be required to capture and report expenses ViiV incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure ViiV’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at SummaryLocation: U