Principal Scientist II

Location Onsite, Cambridge, MA. Overview We are seeking a highly motivated Principal Scientist to join our xDC team and help advance next‑generation targeted therapeutic platforms. This role will contribute to the development and expansion of biologics and drug‑conjugate infrastructure, focusing on innovative vectorization strategies, biology‑informed payload approaches, and differentiated conjugate designs. The ideal candidate will bring strong scientific judgment, hands‑on technical expertise, and experience working in a collaborative, cross‑functional environment. Industry experience in biologics, ADCs, targeted therapeutics, or related modalities is preferred. Key Responsibilities Drive scientific activities supporting the discovery and optimization of next‑generation xDC and biologics platforms. Contribute to the design and evaluation of new vectorization approaches for targeted delivery. Support the development of payload strategies aligned with disease biology and therapeutic mechanism of action. Participate in the exploration of differentiated conjugate formats, including multi‑payload or combination‑based approaches. Work closely with cross‑functional teams across biology, chemistry, protein engineering, pharmacology, translational sciences, and CMC. Design, execute, and interpret experiments to guide platform and program decisions. Identify emerging scientific opportunities and help translate them into actionable research strategies. Communicate results clearly through presentations, reports, and scientific discussions. Contribute to external collaborations and technology evaluation efforts as needed. Maintain awareness of the competitive and scientific landscape in ADCs, biologics, and targeted therapeutic platforms. Essential Requirements Ph.D. in biology, biochemistry, molecular biology, pharmacology, immunology, chemical biology, bioengineering, or a related discipline. 3–5 years of relevant post‑Ph.D. experience, preferably in an industry setting. Experience with biologics, antibody‑drug conjugates, targeted delivery platforms, protein therapeutics, or related modalities. Strong understanding of disease biology, target selection, mechanism‑of‑action studies, and translational research principles. Familiarity with biologics engineering, conjugation strategies, payload biology, or preclinical therapeutic development is preferred. Demonstrated ability to design rigorous experiments, analyze complex data, and make data‑driven recommendations. Strong communication, collaboration, and problem‑solving skills. Ability to work effectively in a fast‑paced, multidisciplinary research environment. Preferred Experience Prior experience in ADC, xDC, or other targeted therapeutic platforms. Experience evaluating novel targets, payload mechanisms, or biology‑driven therapeutic hypotheses. Familiarity with in vitro and in vivo pharmacology workflows. Experience working with external partners, CROs, academic collaborators, or technology vendors. Track record of scientific contributions through publications, patents, presentations, or program advancement. Benefits and Compensation Salary range: $119,700–$222,300 per year. Compensation also includes a performance‑based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. Eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a generous time‑off package including vacation, personal days, holidays and other leaves. Accessibility and Reasonable Accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If you need a reasonable accommodation for any part of the application process or to perform the essential functions of a position, please contact View email address on click.appcast.io. EEO Statement The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. #J-18808-Ljbffr