Principal Scientist--Pharmacokinetics, Dynamics and Metabolism

Principal Scientist position within ADME Sciences focused on pharmacokinetics and metabolism. The role involves leading quantitative metabolism workstreams for small molecule drug discovery and development, managing ADME strategy, risk assessment, and providing scientific recommendations to project teams.

Responsibilities

• Serve as ADME scientific owner for assigned project questions and influence strategy on discovery and development teams
• Design, execute, and interpret enzymology studies addressing clearance, disposition, and drug-drug interaction risk
• Integrate in vitro ADME data to identify liabilities and propose mitigation strategies
• Lead risk assessments for clearance mechanisms, enzyme involvement, and induction or inhibition liabilities
• Mentor scientists through experimental oversight, technical guidance, and coaching to build scientific independence

Requirements

• PhD in related science with 4+ years ADME industry experience, or MS with 9+ years, or BS with 12+ years
• Knowledge of enzymology, drug metabolism, enzyme kinetics, reaction phenotyping, and DDI principles
• Independent experience leading complex ADME workstreams with study design and data interpretation
• Strong written and verbal communication for technical reports and presentations
• Experience mentoring and coaching scientists through experimental planning and data review

Compensation: $106,000–$176,600 base salary, plus 15% bonus target and long-term incentive eligibility