Senior Director, Portfolio and Technology Strategy

Senior Director, Portfolio and Technology Strategy United States - Missouri - St. Louis - Chesterfield We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place. To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding what we need to achieve for patients and how we will go about achieving those goals. Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life‑changing medicines to the world. Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. The Senior Director, Pilot Development, Portfolio Management, Technology & Regulatory Strategy is accountable for providing strategic, technical, and operational leadership across Bioprocess R&D’s non‑GMP pilot plants, portfolio management, and BRD’s regulatory and technology strategy. This role ensures that robust, scalable, and compliant drug substance processes, programs, and technologies are enabled efficiently from early development through clinical readiness. The role serves as a single point of accountability for pilot‑scale execution, portfolio alignment, and integration of development technologies that support Pfizer’s biologics, vaccines, and advanced therapeutic modalities. The role is responsible for coordination and oversight of BRD projects, interfaces with portfolio and technology councils, and overall regulatory strategy coordination with GCMC. The role is global in scope and is a core member of the Bioprocess R&D Leadership Team, partnering closely with Pharmaceutical Sciences, Pfizer Global Supply, Regulatory, Digital, and external collaborators.

ROLE RESPONSIBILITIES

Lead portfolio operations across BRD ensuring alignment of development priorities, pilot capacity, resources, timelines, and execution risk across programs. Design and implement metric‑driven portfolio tracking systems to allow rapid and flexible adjustments to resource allocations according to project prioritizations, collaborating with BRD clinical MFG and the BRD LT. Serve as primary contact to BTxPS Portfolio group, ensuring transfer of information on new projects and technologies into BRD in a timely manner, and coordinate project initiations and progression with ARD and PhRD portfolio groups. Work with the BRD LT to manage new BRD rep assignments, triage project issues for prioritization of BRD LT resources, and facilitate strategic input on portfolio. Provide a mature and experienced perspective on portfolio tracking, project issues, and prioritization to ensure robust oversight and communication of milestones, deliverables, and issues. Provide strategic and technical leadership for non‑GMP pilot plants, enabling effective scale‑up, process characterization, and delivery of drug substance for pre‑clinical and clinical studies. Oversee pilot plant readiness, including equipment strategy, maintenance and turnaround, media and buffer support, and inventory management across sites. Provide strategic leadership for BRD technology strategy, ensuring technology choices support portfolio priorities, scalability, regulatory readiness, and future manufacturing translation. Define and steward the BRD technology roadmap in partnership with Pfizer Global Supply and Digital, including evaluation and deployment of emerging platforms, automation, analytics, and digital enablers. Serve as primary contact to BTxPS technology council, ensuring alignment, visibility, and follow‑through on BRD technology initiatives through project proposal tracking, funding requests, and investment decisions. Develop and implement work plans and strategies in response to new BRD technology initiatives, and mentor BRD staff in pursuit of BRD’s technology strategy. Serve as a point of contact with PGS for BRD initiatives relating to new technologies, technology transfer, and business practices. Oversee BRD legal agreements, external partnerships, and sponsorships, coordinating execution and tracking NDAs, CDAs, MTAs, and collaboration agreements for timely progress and compliance. Leverage exposure to continuously benchmark company’s technology position against emerging technologies in the industry and integrate learnings back into BRD. Ensure regulatory considerations are embedded early in development, scale‑up, and technology decisions in partnership with Regulatory CMC colleagues.

BASIC QUALIFICATIONS

B.S. or M.S. in Chemical Engineering, Biochemical Engineering, Biology, or related field with a minimum of 12+ years of relevant experience in biopharmaceutical development or manufacturing, or Ph.D. with a minimum of 7+ years of experience. Proven experience leading and managing direct reports. Extensive experience/knowledge in process development, pilot‑scale operations, and portfolio enablement for biologics and advanced therapeutic modalities. Demonstrated leadership of complex, multi‑disciplinary, multi‑site organizations in a matrixed environment. Deep understanding of GLP/GMP principles, regulatory guidance, and CMC development expectations. Proven ability to make strategic decisions balancing technical rigor, portfolio priorities, and execution speed.

PREFERRED QUALIFICATIONS

Experience leading portfolio planning, governance, or development operations for a complex biologics pipeline. Experience advancing novel development or manufacturing technologies into clinical programs. Strong track record of cross‑functional influence across Research, Manufacturing, Regulatory, and Digital organizations. Experience working with or transitioning programs to commercial manufacturing organizations. Experience managing external collaborations, consortia, or strategic partnerships related to process or technology innovation.

PHYSICAL/MENTAL REQUIREMENTS

Ability to work effectively in office, laboratory, and pilot‑plant environments. Ability to evaluate and integrate complex technical, operational, and portfolio information to make strategic decisions. NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS 15‑20% travel required to other sites, manufacturing facilities, and partner locations. Periodic off‑hours support aligned with critical development or operational milestones.

ORGANIZATIONAL RELATIONSHIPS

Pharmaceutical Sciences technical lines (ARD, PhRD) Pfizer Global Supply (PGS) Regulatory CMC Transformational Technology (TTDS) External technology partners and consortia BRD Leadership Team Portfolio strategy group (BPS)

SUPERVISION

Role will require supervision of direct reports who may be individual contributors and/or people leaders, with matrix responsibility across BRD technical lines and SMEs. Candidate demonstrates a breadth of diverse leadership experiences and capabilities, including the ability to influence and collaborate with peers, develop and coach others, and oversee and guide the work of colleagues to achieve meaningful outcomes and create business impact. Relocation support available. Work Location Assignment: Hybrid. The annual base salary for this position ranges from $230,900.00 to $384,800.00. This position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 25.0% of the base salary and long‑term incentive program. Comprehensive and generous benefits are offered, including a 401(k) plan with matching contributions, retirement savings contributions, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits covering medical, prescription drug, dental, and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits.

SUNSHINE ACT

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the Sunshine Act. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements. Pfizer is an E‑Verify employer. This position requires permanent work authorization in the United States. Candidates must be authorized to be employed in the United States by any employer. U.S. work visa sponsorship (such as TN, O‑1, H‑1B, etc.) is not available for this role now or in the future. #J-18808-Ljbffr Pfizer, S.A. de C.V