Associate Principal Scientist, Preclinical Research

Philadelphia, PACategory: ResearchType: Full-timeMin. Experience: Senior LevelPosition Title: Associate Principal Scientist, Preclinical ResearchLocation: Hybrid/Philadelphia, PAReports to: Vice President, Preclinical ResearchDepartment: Preclinical ResearchCabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit and connect with us on LinkedIn.Uniquely Differentiated. Rapid. Elegant.At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. We’re proud to be a Great Place to Work-Certified company! #GPTWcertified Check out what our employees say makes working here so great: Working at Cabaletta Bio Inc | Great Place to WorkAbout the Position: Reporting to the Vice President, Preclinical Research, we are seeking an experienced and motivated Associate Principal Scientist. The successful candidate will work in discovery research as a molecular biology and gene delivery subject matter expert, collaborating cross-functionally with other teams within discovery research (Cellular Immunology, Pharmacology, CMC, etc) and more broadly with other departments in Cabaletta to establish a product pipeline and to support preclinical IND enabling studies. They will oversee and lead a team of individuals tasked with developing and implementing molecular biological assays and reagents and will oversee the use of these assays to assess both novel and existing platforms.Responsibilities:Management of a team of employees that are responsible for executing R&D experiments, designing and implementing assays, and supporting reagent production to enable short and long-term success.Support new preclinical discovery projects by working closely with scientists in the lab to design and execute critical experiments. Oversee the planning, timely execution, and interpretation of team laboratory work, per program timelines.Assist in identifying critical resources needed to meet discovery research objectives, including people, equipment, supplies, and space.Collaborate with cross-functional peers/ senior management to set team objectives, gain alignment, communicate results and project status, and meet company objectives.Actively contribute to process improvements and the implementation of new technologies by being a subject matter expert in the field of molecular biology and gene delivery. Required Qualifications:PhD in Molecular Biology/ Cell Biology or another similar fieldAt least 2 years of biotechnology industry experienceDemonstrated expertise with advanced molecular biology techniques, assay development, and implementation.Demonstrated experience with a variety of methods to enable gene delivery to primary T-cells (e.g. Lentiviral vectors, lipid nanoparticles, AAV, etc.)Strong leadership and management skills with a track record of achievement, and demonstrated ability to operate in cross-functional collaborative environments.Ability to clearly communicate both in writing and via scientific presentations,Must have a desire to be part of a growing early stage organization that uses cutting-edge science.A high level of flexibility to support evaluation of new technologies, possibly outside of existing field of expertise, and the ability to learn and guide junior team members in evaluating and developing those technologies following evaluation.Preferred Qualifications: Prior management of direct reports in the biotechnology industry.Hands-on experience with technologies for gene delivery to primary T-cells including lipid nanoparticles and viral vectors.Prior experience in a fast-paced start-up biotechnology company.Experience in the design and execution of in vivo studies to assess CAR-T cells in murine and non-human primate models.Experience supporting IND-enabling studies for CAR-T related therapies.Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.For more information, please visit Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans. Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.#LI-HYBRID