Ligand Binding Assays Scientist - PK/PD & RNAi Programs
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is seeking a highly motivated Scientist in Cambridge, MA, specializing in ligand binding assays. This role involves designing and implementing assays to quantify oligos, proteins, peptides, and antibodies, aiding drug development efforts. The ideal candidate will have a strong background in molecular biology or biochemistry and be skilled in problem-solving and communication for effective collaboration. This is an onsite position part of a vibrant team driving RNAi therapeutic advancement. #J-18808-Ljbffr Alnylam Pharmaceuticals
- ## Scientist, Ligand Binding AssaysUnited StatesApply NowFind out... ...in ligand binding assays to quantify oligos,... ...stage drug development programs to inform on target... ...pharmacodynamics (PD), pharmacokinetics (PK), mechanism of... ...safety, to advance RNAi therapeutic development...SuggestedFull timeTemporary workLocal areaFlexible hours
- Alnylam Switzerland GmbH is looking for a Scientist specializing in ligand binding assays, located in Cambridge, MA. This role involves designing and implementing assays for drug development and requires strong expertise in molecular biology and biochemistry. Responsibilities...Suggested
- ...Co., Ltd is looking for an In Vivo Biologist in Boston to join the Translational Pharmacology group. This role focuses on designing PK/PD studies for autoimmune diseases, and requires prior drug discovery experience. Candidates must possess strong technical capabilities...Suggested
$157k - $213k
...modalities including RNAi silencing and RNA... ...148M liver disease programs and also includes clinical... ...detail-oriented Scientist with strong... ...interpreting pharmacokinetic (PK), toxicokinetic (TK), plasma protein binding and in‑vitro drug‑... ...i.e., ADME, PK, PK/PD) to support...SuggestedTemporary workSummer workWork at officeLocal area- ...is seeking a highly motivated Scientist with expertise in bioanalytical... ...to support RNA‑based drug programs from preclinical to clinical stages... ...designing and interpreting PK/TK studies across cross‑functional... ...experience, strong PK/PD knowledge, and experience with...Suggested
$120k - $145k
...advancing additional Helicon-based programs focused on other challenging... ...is seeking a driven bench scientist who thrives at the... ...equally energized by building new assays from scratch and delivering the... ...multiple assay formats, including binding assays, target engagement and...Shift work- ...highly motivated Senior Scientist, In Vitro Pharmacology... ...in vitro pharmacology assays that inform efficacy, potency... ...progress of discovery programs while “leading from the... ...results with PK/PD and mechanistic insights... ...SLC function /transport/ binding assay, 4) prior experience...
- ...off Stock options plan Scientist/Senior Scientist,... ...diseases leveraging our novel ligand‑guided siRNA delivery... ..., and translational assay development, with a strong... ...impact therapeutic programs from target discovery through... ...knockdown In vivo PK/PD, biodistribution, efficacy...
- ...Pharmaceuticals, Inc. is looking for an Associate Scientist II in Cambridge, MA to join the Next... ..., you will design studies to evaluate RNAi compounds and conduct laboratory assays, contributing to the progression of therapeutic programs. The ideal candidate holds a B.S. in a...
- Novartis Group Companies is seeking a Senior Scientist II in Cambridge, MA, to join their Translational Medicine Drug Disposition Discovery Bioanalytical group. This role involves providing lab-based bioanalytical support for drug discovery projects and requires strong...
$121k - $172k
...2,000 Summary The Scientist, Bioanalytical Development... ...preclinical/clinical programs to assess PK. ADA and PD in preclinical and clinical... ...Responsibilities Develop ligand binding methods including... ...and pharmacodynamic (PD) assays. Design and independently...Full timeWork experience placementLocal areaFlexible hours$80k - $120k
Alnylam Pharmaceuticals in Cambridge is seeking a Senior Associate Scientist to join their Research department. The successful candidate will support the development of therapeutic programs and work on RNAi compounds targeting metabolic diseases. Ideal qualifications...Full time- ...mediated and rare diseases. Jnana's lead program is a potential first-in-class oral approach... ...platform with a range of cell-based assays, our research aims to unlock difficult to... ...to design and implement mouse models of PK/PD and efficacy for autoimmune diseases. Prior...
- ...Pharmaceuticals in Cambridge, MA seeks a Senior Associate Scientist to join the Investigative Sciences team. You will conduct mechanistic RNAi studies in vitro and in vivo, handling... ...techniques to support fast-paced discovery programs. The role emphasizes rigorous data analysis,...
- ...motivated and accomplished scientist to lead the Bioanalytical (BioA) and PK/PD function. This role is... ...environment. Beyond assay management, you will serve... ...selection and program progression. Principal... ...quantitation and MSD-based ligand-binding assays (LBAs)....
$96.5k - $183.5k
...Medicine (BGM) team. As a Senior Scientist in our siRNA group, you will be part... ...across multiple pipeline programs. Design and execute receptor expression profiling, ligand-receptor binding, internalization, and trafficking assays. Evaluate functional delivery and...Full timeTemporary workLocal area$115k - $215k
Kymera Therapeutics is looking for a talented scientist with expertise in targeted proteomics to join our team in Boston, MA. The successful candidate will lead scientific initiatives, collaborating with cross-functional teams to drive innovative drug discovery. Qualifications...$110.4k - $165.6k
Overview We are seeking a scientist to join our... ...team to help advance our RNAi therapeutics platform by... ...toxicity and de-risking siRNA ligand candidates through... ...vendors on technology and assay evaluation, where appropriate... ...reimbursement program, flexible spending and...Full timeTemporary workLocal areaFlexible hours- ...collaborative multidisciplinary Senior Scientist to join our dynamic Platform... ...Contribute to therapeutic discovery program teams, leading screening/selection... ...discovery engine Develop and validate ligand‑binding and cell‑based assays that enable hit characterization...
- ...motivated and innovative Senior Scientist II to join the Rheumatology... ...support preclinical drug discovery programs in rheumatology, with focus on... ...candidates, including establishing PK/PD relationships, developing, and optimizing screening assays, designing and executing...Local areaImmediate start
- ClinLab Solutions Group is seeking a Scientist or Senior Scientist to join their Assay Development team in Cambridge, MA. This position focuses on developing... ..., aiming to improve preclinical and discovery program outcomes with innovative laboratory approaches. #J-1...
- Overview Cambridge, MA Summary: Seeking a Scientist or Senior Scientist to join an Assay Development team supporting discovery and preclinical programs. The position involves immunology-focused cell-based assay development and preclinical sample analysis, working closely...
- ...Protein Innovation (IPI) in Boston, MA, seeks a senior neuroscience program manager to bridge science and operations within the... ...to conferences to represent IPI. You will also develop neuronal assays, collaborate with external partners on antibody applications, contribute...
$80k - $120k
...is seeking a Senior Associate Scientist to contribute to our ligand discovery efforts for expanding RNAi delivery to all tissues. The successful... ...techniques and cell‑based assays (ELISA, BLI/SPR, flow... ...insurance, a lifestyle reimbursement program, flexible spending and health...Full timeTemporary workLocal areaFlexible hours- ...Summary The Associate Scientist, Analytical Development... ...of bioanalytical assays. This role requires hands... ...e.g., potency assays, binding assays, reporter gene... ...impact on analytical programs Cell Culture Maintenance... ...Discovery), or equivalent ligand binding assay...
$105.04k - $127.29k
...competitive benefits, services and programs that provide our employees... ...in Cambridge and Seattle, scientists focus on novel targets and pathways... ...conduct in vivo efficacy and PK/PD studies and experiments... ...characterize them using cell-based assays. Accurately maintain proper...Hourly payFull timeTemporary workPart timeFor contractorsSummer workWork at officeLocal areaRemote workFlexible hoursShift work$120k - $140k
...and international conferences to represent the IPI Neuroscience Program Lead and coordinate activities for multiple projects to meet... ...reports to leadership Scientific Research (50%): Develop neuronal assays to test antibody potency and investigate multiplexing...Immediate startFlexible hours- ...Discovery Biology team. You will drive early programs from hit finding through initial lead strategies, focusing on cell-based assays and GPCR biology. Collaborating with... ...’ll shape biology strategy, mentor junior scientists, and communicate findings across project teams...
$126k - $234k
...Internal Title: Principal Scientist II or Senior Principal Scientist... ...informed approaches that shape program strategies. As part of a truly... ...pharmacology (QSP) and mechanistic PBPK/PD approaches to inform key... ...and apply mechanistic models (PK/PD, QSP, and PBPK/PD) that...- ...seeking a creative, motivated Computational Scientist to join our Model-Driven Design team at... ...to maximize reuse across targets and programs. Propose new therapeutic strategies:... ...experiments and experimental data (e.g., binding assays, stability measurements, structural...Work at office
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