Senior Scientist, DMPK & PK for RNA Therapeutics
Wave Life Sciences
Wave Life Sciences is seeking a highly motivated Scientist with expertise in bioanalytical and DMPK sciences to support RNA‑based drug programs from preclinical to clinical stages. This hybrid role is based in Lexington, MA and involves designing and interpreting PK/TK studies across cross‑functional teams. The ideal candidate will have a PhD or MS with significant industry experience, strong PK/PD knowledge, and experience with PK software tools. #J-18808-Ljbffr Wave Life Sciences
- Lilly is seeking a Senior Principal Scientist to drive analytical characterization of circular RNA and lipid nanoparticle-based therapeutics with a focus on mass spectrometry. The candidate will develop and qualify LC-MS/MS assays and lead method transfer to partners in...Senior
$157k - $213k
...the broad potential of RNA medicines to transform... ...motivated and detail-oriented Scientist with strong expertise... ...and Pharmacokinetics (DMPK) sciences to support... ...interpreting pharmacokinetic (PK), toxicokinetic (TK),... ...advancement of RNA therapeutic programs Autonomously...SeniorTemporary workSummer workWork at officeLocal area- Alnylam Pharmaceuticals, Inc. in Cambridge, MA is seeking a DMPK Scientist to design and interpret in vitro and in vivo ADME and PK/PD studies for siRNA and other modalities, informing human dose projections and candidate selection. You will build quantitative models and...Suggested
$179k - $236k
...Scientific Officer, this role leads DMPK and bioanalytical strategy... ...DMPK and bioanalytical scientist with experience in PK study design, bioanalytical... ..., or nucleic acid / RNA therapeuticsFamiliarity with... ...indications. The company’s initial therapeutic programs are designed to...Senior$119.7k - $222.3k
...enthusiastic and motivated PK Sciences representative... ...molecules, biologics/therapeutic proteins, antibody drug... ...role overseeing ADME/DMPK project strategy in clinical... ...for Principal Scientist II. 4+ years of experience... ...experience to be considered for Senior Principal Scientist....SeniorFull time$119.7k - $222.3k
...enthusiastic and motivated PK Sciences representative... ...molecules, biologics/therapeutic proteins, antibody drug... ...role overseeing ADME/DMPK project strategy in clinical... ...for Principal Scientist II. 4+ years of experience... ...experience to be considered for Senior Principal Scientist....Senior$129k - $203.1k
...Bioanalytics (PDMB) is seeking a curious and collaborative Senior Scientist for our growing Translational PK/PD organization. The Translational PK/PD Senior... ...strategy with a focus on biologics, protein therapeutics, and peptides.The Translational PK/PD Senior Scientist...SeniorFull timeFor contractorsLocal areaFlexible hours- Orna Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company, seeks a Senior Principal Scientist to drive analytical characterization of circular RNA and LNP-based therapeutics, focusing on LC‑MS/MS methods and cross‑functional collaboration in a fast-paced...Senior
- Orna Therapeutics, Inc. seeks a Senior Principal Scientist to drive analytical characterization of circular RNA and lipid nanoparticle therapeutics, focusing on mass spectrometry. You will collaborate with Platform Science, Discovery, and CMC to advance method development...Senior
$129k - $203.1k
The Translational PK/PD Senior Scientist will: Serve as PK/PD modeler in cross-functional teams to support model-informed decisions on drug... ...informing discovery/development decisions for biologics, protein therapeutics, and/or peptides. Interdisciplinary teamwork and...Senior- Senior Scientist, Bioanalysis & Biomarkers Nonclinical Development... ...the way for new RNA medicines for systemic... ...discover and develop therapeutics that have the potential... ...partner closely with DMPK, Pharmacology, Toxicology... ...and strengthen PK/PD and exposure-response...SeniorFull timeLocal area
$129k - $203.1k
...Bioanalytics (PDMB) is seeking a curious and collaborative Senior Scientist for our growing Translational PK/PD organization. The Translational PK/PD Senior... ...strategy with a focus on biologics, protein therapeutics, and peptides. The Translational PK/PD Senior Scientist...SeniorFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work- Noara Therapeutics, Cambridge, MA, is seeking a Senior Scientist or Scientist with deep expertise in cell biology, immunology, and assay development to lead the... ...biology, automation, and data science teams to develop scalable assays for our RNA‑LNP #J-18808-Ljbffr C10 LabsSenior
- ...pharmacokinetic/pharmacodynamic (PK/PD) relationships of oligonucleotide therapeutics and other emerging... ...as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership... ...effectively to project teams, senior management, external...Full timeTemporary workWork at officeLocal areaFlexible hours
$176.2k - $277.3k
...and collaborative Principal Scientist (director-level equivalent) to... ...metabolism and pharmacokinetic (DMPK) efforts across multiple... ...such as peptides and protein therapeutics as a project-team representative... ...and interpretation of PK and PK/PD data sets and through...Full timeFor contractorsLocal areaWorldwideFlexible hours- Alnylam Pharmaceuticals in Cambridge, MA seeks a DMPK Scientist to design and interpret ADME and PK/PD studies for siRNA and other modalities, applying quantitative pharmacology to guide candidate selection and human dose predictions. The role demands expertise in non-...
- Moderna is seeking a Senior Scientist to lead computational efforts in translational bioinformatics for mRNA therapeutics and vaccines. You will apply advanced analytics to bulk and single-cell data, TCR/BCR repertoires, and multi-omics to uncover targets, mechanisms,...Senior
- Sail Biomedicines is seeking a Senior Research Associate for high-throughput RNA production to advance Endless RNA™ technology. You will perform end-to-end RNA generation from template cloning to IVT, manage materials, and help optimize workflows in a fast-paced environment...Senior
- Strand Therapeutics, a Boston-based biotech, seeks a Senior/Principal Associate Scientist to join the mRNA Programming group, advancing RNA LNP therapeutics in oncology and beyond. You will lead experiments, drive discovery, and collaborate across teams to shape next-generation...Senior
- Sail Biomedicines is seeking a Senior Research Associate in Platform RNA Sciences to advance Endless RNA™ technology. You will optimize eRNA purification, improve circularization, and contribute to design and data analysis in a fast-paced environment with real-world patient...Senior
- Moderna, based in Cambridge, MA, seeks a Senior Research Associate for the RNA Innovation team to study the chemical biology of mRNA and how RNA modifications affect metabolism and performance. The role involves designing experiments using in vitro biochemistry and cell...Senior
- OverviewThe mission of DMPK is to enable efficient and successful... ...of siRNA and other therapeutic candidates by characterizing... ...metabolism, and excretion) and PK/PD (pharmacokinetics/pharmacodynamics... ...with highly motivated scientists across a broad array of disciplinary...Full timeTemporary workLocal areaFlexible hours
- Atalanta Therapeutics in Boston’s Seaport is seeking a Senior Scientist I to join our Research team and drive discovery and preclinical development of novel CNS therapeutics. This lab-based role blends hands-on execution with scientific leadership, owning experimental...Senior
$150k - $180k
...proprietary AI platform decodes the complexity of RNA biology to identify novel drug targets, mechanisms, and therapeutics inaccessible through traditional methods. With... ...Future responsibilities may include bioanalysis of PK samples. Basic Qualifications PhD in...SeniorLocal areaFlexible hoursWeekend work$126k - $234k
...Summary#LI-Hybrid Internal Title: Principal Scientist II or Senior Principal ScientistLocation: Cambridge... ...eager to accelerate oligonucleotide therapeutics (xRNA”), including antibody-xRNA... ...• Build and apply mechanistic models (PK/PD, QSP, and PBPK/PD) that link drug pharmacology...SeniorFull time$105.04k - $127.29k
Job Title: R1603459 : Senior Associate Scientist, In Vivo Pharmacology, Oncology... ...development of novel oncology therapeutics for patients. Centered at... ...engineering/antibody development, DMPK and translational group.... ...in vivo efficacy and PK/PD studies and experiments...SeniorHourly payFull timeTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work- Bristol Myers Squibb is seeking a Scientist to join the RNA Sciences and Preclinical Manufacturing team in Cambridge, MA. The role focuses on developing bench-scale manufacturing for preclinical DNA and mRNA materials and supporting various molecular biology workflows essential...
- Korro Bio in Cambridge, MA, is seeking a Scientist I to advance cell biology and RNA-based therapeutics. You will design and execute cell-based assays, establish hepatocyte... ..., and work closely with in vivo pharmacology and DMPK teams to drive pharmacodynamic understanding. The...
- The client is seeking an experienced Senior Scientist to join their Bioanalytical Sciences team... ...IND-enabling studies for our mRNA-LNP therapeutics. You will be a subject matter expert in... .... You will report into the VP, Head of DMPK and Clinical Pharmacology, with the expectation...Senior
- City Therapeutics in Cambridge, MA, seeks a Sr. Scientist, Bioanalytical Biomarker Sciences, to lead assay development and biomarker work across discovery and early development. You will oversee CROs, guide PK/PD analyses, and drive data-based decision making from candidate...Senior
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