Senior Director, Financial Planning & Analysis - R&D

Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD), Pompe disease and multiple DMD mutations. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at and follow us on X, LinkedIn and Facebook.

Role Summary:

The Senior Director, FP&A serves as a strategic finance leader responsible for advancing Dyne’s financial planning, forecasting, reporting, and decision-support capabilities across the Research & Development organization. This role partners closely with Finance leadership, the CFO, functional leaders, program and project teams, and cross-functional stakeholders to translate scientific, operational, and corporate priorities into disciplined financial plans, actionable insights, and clear executive-level recommendations.

This leader is a strategic leader who inspires action, manages interdependencies, allocates resources effectively, and influences decisions across functions. The role requires deep FP&A expertise, strong business judgment, and the ability to synthesize complex financial, operational, and portfolio information to guide planning, investment decisions, scenario modeling, resource allocation, and long-range financial strategy. This leader strengthens scalable FP&A processes, tools, reporting, and operating rhythms to support Dyne’s continued growth and mission of delivering meaningful outcomes for patients.

This role is based in Waltham, MA.

Primary Responsibilities Include:

• Lead annual budgeting, quarterly forecasting, long-range planning, and scenario modeling processes across R&D functions: Research, Clinical Development, Regulatory and Portfolio Strategy & Operations and the cross-functional program leadership team
• Partner with the VP, FP&A to develop, manage, and continuously improve Dyne’s enterprise planning calendar, planning assumptions, financial models, templates, reporting packages, and governance processes
• Serve as a trusted finance business partner to R&D functions: Research, Clinical Development, Regulatory and Portfolio Strategy & Operations and the cross-functional program leadership team, providing financial insights that support strategic decision-making, portfolio prioritization, operating discipline, and resource allocation
• Translate program timelines, clinical development plans, headcount plans, vendor commitments, and functional priorities into clear financial forecasts and actionable recommendations
• Partner closely with the program leadership team and Clinical Operations to develop and manage a live clinical trial forecasting model that clearly identifies key assumptions and drivers, enabling robust scenario planning and informed investment decisions
• Lead program- and function-level budget reviews, challenging assumptions, identifying risks and opportunities, and ensuring alignment between financial plans, corporate goals, program milestones, and functional priorities
• Develop and maintain robust financial models, dashboards, and reporting tools that provide visibility into spend, cash runway, operating performance, clinical and program costs, headcount, and key business drivers
• Prepare and present executive-ready financial analyses, variance explanations, forecast updates, and recommendations for Finance leadership, the CFO, senior leadership, and other governance forums as needed
• Lead monthly and quarterly actuals reporting, variance analysis, accrual support, and close-related FP&A activities in partnership with Accounting, Procurement, and functional budget owners
• Partner with Accounting to ensure appropriate expense recognition, accrual accuracy, budget-to-actual transparency, and alignment with US GAAP, SOX requirements, and company policies
• Support strategic analyses related to capital planning, cash runway, business development opportunities, program investment decisions, launch readiness, and other enterprise priorities
• Identify, implement, and scale process improvements that increase forecast accuracy, planning discipline, reporting consistency, transparency, and efficiency across the FP&A function
• Support implementation, optimization, and adoption of financial planning systems and enterprise tools, including planning applications, reporting dashboards, and related integrations
• Foster accountability and financial ownership across the organization by enabling clear communication, practical guidance, and consistent operating rhythms with functional leaders and budget owners
• Build, coach, and develop FP&A talent as the function evolves, creating a collaborative, inclusive, high-performing team culture grounded in Dyne’s values
• Model Dyne’s core values by leading with purpose, accountability, transparency, collaboration, sound judgment, and a commitment to continuous improvement
• Perform ad-hoc financial analysis and support special projects as required

Education and Skills Requirements:

• Bachelor’s degree in Finance, Accounting, Economics, Business, or a related field
• Advanced degree, CPA, CFA, or MBA preferred
• 15+ years of progressive finance, FP&A, corporate finance, strategic finance, or related experience, preferably in biotechnology, pharmaceuticals, life sciences, or another high-growth R&D-driven environment
• 8+ years of experience leading people, teams, major workstreams, or a finance function, directly or through cross-functional leadership
• Strong understanding of biotechnology financial drivers, including R&D investment planning, clinical development spend, ROI analysis, program timelines, vendor commitments, headcount planning, operating expense management, and cash runway considerations
• Experience building and maintaining live clinical trial forecasting models, with the ability to identify key cost assumptions and drivers and support scenario planning across clinical programs
• Demonstrated ability to lead annual planning, forecasting, long-range planning, management reporting, scenario analysis, and executive-level financial presentations
• Experience partnering with R&D, Clinical Development, CMC, Technical Operations, Commercial, G&A, or other functional leaders to align operating plans with corporate strategy and financial targets
• Strong working knowledge of US GAAP, SOX requirements, accrual processes, budget-to-actual reporting, financial controls, and close-related FP&A responsibilities
• Deep financial modeling, analytical, and problem-solving skills, with the ability to synthesize complex data into clear insights, recommendations, and trade-off decisions
• Demonstrated ability to influence senior stakeholders, reconcile multiple perspectives, manage interdependencies, and drive outcomes in a matrixed environment without relying solely on formal authority
• Proven ability to build scalable processes, reporting infrastructure, financial models, dashboards, and planning tools that improve transparency, accountability, and decision-making
• Strong executive presence and communication skills, including the ability to prepare and deliver concise, accurate, and compelling materials for senior leaders and governance forums
• High proficiency with Microsoft Office products, especially Excel and PowerPoint; experience with financial planning systems, ERP systems, and reporting tools preferred
• Strong organizational and project management skills, with the ability to manage multiple priorities, meet tight deadlines, and maintain high-quality work in a fast-paced environment
• Sound judgment, high integrity, attention to detail, and commitment to compliance, confidentiality, and financial discipline
• Collaborative, solutions-oriented leader who builds trust, empowers others, promotes accountability, and contributes to a positive and inclusive team culture
• Excitement about Dyne’s mission, operating environment, and core values

#LI-Onsite

MA Pay Range

$233,000—$285,000 USD

The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills.

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.