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Senior Associate Scientist - RGM Chemistry

Scorpion Therapeutics

What You'll Do Senior Associate Scientist focused on oligomer synthesis and characterization: Execute solid-phase oligomer and oligonucleotide synthesis using automated synthesis platforms (prepare reagents, set up synthesis cycles, incorporate standard and chemically modified amidites, perform on-bead or post-synthetic modifications as needed). Support synthesis of RNA-related constructs of varied lengths, formats, and chemical modifications. Develop, optimize, and troubleshoot synthetic workflows to improve yield, purity, reproducibility, and process efficiency. Purify synthesized oligomers using chromatography (size-exclusion, anion-exchange, reverse-phase, ion-pair reverse-phase). Characterize materials using LC-MS, HPLC/UPLC, UV-Vis, and other orthogonal techniques. Analyze/interpret results, summarize findings, and recommend next steps for iterative chemistry design. Maintain accurate, complete, and timely experimental records. Support routine operation, maintenance, troubleshooting, and inventory management for key instrumentation and supplies. Collaborate with chemists, biologists, analytical scientists, and project teams. Let's Find Out If We're a Fit B.S. in chemistry, biochemistry, chemical biology, biology, or related field required; M.S. preferred. Minimum 5 years (B.S.) / 3 years (M.S.) in relevant research, internship, or industry experience required. Preferred: hands-on solid-phase organic synthesis experience (oligonucleotide/peptide/oligomer/polymer/biopolymer workflows). Nice to have: automated synthesis platforms (MerMade, OligoSynt, or comparable); experience with SEC, AEX, RP-HPLC/RPIP-HPLC, and LC-MS. #J-18808-Ljbffr Scorpion Therapeutics

Vacancy posted 2 days ago
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