Senior Scientist

Lead the design and optimization of next-generation affinity purification technologies for a wide range of biopharmaceutical modalities. This role combines high-throughput experimentation, data-driven process development, and cross-functional collaboration to deliver innovative purification solutions that accelerate bioprocessing performance and enable partner success. “This role is expected to model our Leadership Behaviors—Integrity & Compliance, Customer Focus, Collaboration, Courage, Team Empowerment, and Accountability & Results—in all aspects of work.” Key Responsibilities Design, develop, and optimize affinity chromatography–based purification processes for diverse biopharmaceutical modalities Execute high-throughput chromatographic screening and apply DOE methodologies to accelerate process development Analyze, interpret, and communicate complex datasets to drive decision-making and support partner adoption of new technologies Collaborate cross-functionally with internal teams (chemistry, analytics, commercial) to deliver integrated purification solutions Contribute to multiple development programs, ensuring timely execution and high-quality scientific output Innovate and propose novel approaches to improve purification performance, selectivity, and scalability Engage with external biopharma partners as a technical expert and scientific collaborator Qualifications MS or PhD in Biochemistry, Chemical Engineering, Biochemical Engineering, or related field Minimum of 5 years of hands-on experience in downstream processing and protein purification; including FPLC Experience across multiple modalities (e.g., proteins, enzymes, vaccines, VLPs, gene therapy vectors) Expertise in chromatography method development, including automated/high-throughput systems Strong proficiency with Design of Experiments (DOE) for process optimization Working knowledge of analytical techniques (e.g., purity/impurity analysis, potency, stability assays) Broad scientific understanding spanning separations, protein chemistry, and bioprocessing Strong communication skills with the ability to translate data into clear, actionable insights Self-motivated, collaborative, and effective in a fast-paced, innovation-driven environment Our mission is to inspire advances in bioprocessing as a trusted partner in the production of biologic drugs that improve human health worldwide. Focused on cost and process efficiencies, we deliver innovative technologies and solutions that help set new standards in bioprocessing. The estimated hourly rate/salary range for this role, based in the United States of America is $115,000-$145,000. Compensation decisions are dependent on several factors including, but not limited to an individual's qualifications, location, internal equity, and alignment with market data. Additionally, employees are eligible to participate in one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits such as paid time off, health/dental/vision, retirement benefits and flexible spending accounts. All compensation and benefits information will be confirmed in writing at the time of offer. Thank you for your interest in Repligen! Working at Repligen means being part of a team that is excited to find new and creative ways to overcome challenges in bioprocessing — and to help our customers make a difference in the world.