Senior Manager, Marketing Operations

_ Who We Are: _ Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team. _ What We Do: _ We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are important pain targets. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations. _ About the Role: _ Xenon is seeking a Senior Manager/Associate Director, Marketing Operations & Commercial Review to lead the commercial review committee and enable scalable, compliant, and high-quality delivery of programs and tactics. This role will work in close partnership with Marketing, Regulatory, Legal, Medical Affairs, Compliance, and IT to ensure seamless coordination, efficient processes, and strong governance across all marketing activities. This position is critical in a fast-paced, pre-launch environment and requires a highly organized, proactive leader with deep experience in marketing operations, MLR/CRC processes, and cross-functional execution. This position reports to the Vice President, Commercial Operations, and will be based out of Boston, MA, USA in our Needham office. Hybrid positions require a minimum of two onsite days per week. RESPONSIBILITIES: Marketing Operations & Process Excellence Lead the design, optimization, and execution of the Commercial Review Committee (CRC/MLR) process, ensuring alignment with Marketing, Regulatory, Legal, Medical, and Compliance stakeholders Continuously assess and improve CRC workflows, identifying bottlenecks, redundancies, and cycle-time challenges; proactively propose and implement solutions to enhance efficiency and quality Serve as primary CRC operations lead, either directly coordinating reviews or managing an outsourced/vendor-supported model depending on capacity and business needs Establish and manage CRC governance forums, including coordinating CRC steering committees, setting agendas, and aligning stakeholders on process improvements and priorities Lead and coordinate the Executive Review Committee escalation governance committee Partner with IT and cross-functional teams to manage systems supporting CRC workflows (e.g., Veeva PromoMats or similar), including user access, license management, and system enhancements Lead the development and delivery of training programs for CRC processes, systems, and ways of working across Marketing and cross-functional partners Stay current on industry best practices, emerging technologies, and innovation (including AI-enabled content and review solutions); identify opportunities and drive adoption of new capabilities to improve efficiency and scalability Collaborate cross-functionally to evaluate and enhance the end-to-end content lifecycle, including: Content intake and planning Content creation and modular content strategy Digital asset management (DAM) and content libraries Content reuse and optimization Develop and align stakeholders to a forward-looking roadmap for content operations maturity and implement prioritized enhancements Lead the vendor selection, process development, and day to day coordination with marketing and other partners on materials printing and fulfillment management Coordination & Planning Partner closely with Marketing leadership to forecast review volume, assess capacity, and plan for fluctuations in workload and complexity Proactively identify risks related to throughput, timelines, or resource constraints and develop mitigation plans in alignment with cross-functional stakeholders Drive integrated planning and scheduling of marketing materials through the CRC process to ensure timely delivery of key campaigns, launches, and field materials Act as a central point of coordination across Marketing, Regulatory, Legal, Medical, and Compliance to ensure alignment on priorities and timelines Vendor & Agency Management Manage external vendors and agency partners supporting: CRC operations (if outsourced components are implemented) Print, fulfillment, and material distribution Define scope of work, performance expectations, and service-level agreements (SLAs) for vendors Monitor vendor performance against KPIs and drive continuous improvement Track budgets related to marketing operations and vendor services, ensuring efficient and compliant resource utilization Performance Enablement Define, implement, and track KPIs for marketing operations and CRC performance, including cycle times, approval rates, rework levels, and throughput Develop and maintain operational dashboards and reporting to provide transparency into process performance and identify improvement opportunities Use data-driven insights to continuously refine processes and improve effectiveness Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any Some international travel may be required Other duties as assigned QUALIFICATIONS: Required Bachelor’s degree required 6–10+ years of experience in marketing operations within pharmaceutical/biotech or agency environments Demonstrated experience with: MLR/CRC processes and governance Campaign operations and asset lifecycle management Vendor and agency management Strong understanding of regulatory and compliance requirements in pharmaceutical marketing Preferred Experience in launch or pre-launch environments, particularly in specialty or rare disease Experience with Veeva PromoMats or similar systems Exposure to omnichannel marketing and modular content strategies Experience implementing process improvements or transformation initiatives Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions. Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees. #J-18808-Ljbffr