HR Manager

About Us Protagonist Therapeutics is a biopharmaceutical company built on a proprietary peptide technology platform that has now produced two FDA-approved, first-in-class medicines, generating royalties and milestones from global commercial partnerships with Johnson and Johnson and Takeda Pharmaceutical Company Limited. ICOTYDE™ (icotrokinra), licensed to Johnson & Johnson company Janssen Biotech, Inc., is the first and only targeted oral peptide that precisely blocks the Interleukin-23 receptor. ICOTYDE was launched in the U.S. in March 2026 for the treatment of moderate-to-severe plaque psoriasis in adults and pediatric patients 12 years of age or older and is in Phase 3 development for psoriatic arthritis, ulcerative colitis and Crohn's disease. ICOTYDE was jointly discovered by Protagonist and Johnson & Johnson scientists, with Protagonist having primary responsibility for the development of ICOTYDE through Phase 1, and Johnson & Johnson About Us Protagonist Therapeutics is a biopharmaceutical company built on a proprietary peptide technology platform that has now produced two FDA-approved, first-in-class medicines, generating royalties and milestones from global commercial partnerships with Johnson & Johnson and Takeda Pharmaceutical Company Limited. ICOTYDE™ (icotrokinra), licensed to Johnson & Johnson company Janssen Biotech, Inc., is the first and only targeted oral peptide that precisely blocks the Interleukin-23 receptor. ICOTYDE was launched in the U.S. in March 2026 for the treatment of moderate-to-severe plaque psoriasis in adults and pediatric patients 12 years of age or older and is in Phase 3 development for psoriatic arthritis, ulcerative colitis and Crohn's disease. ICOTYDE was jointly discovered by Protagonist and Johnson & Johnson scientists, with Protagonist having primary responsibility for the development of ICOTYDE through Phase 1, and Johnson & Johnson assuming responsibility for further clinical and regulatory development and commercialization. Protagonist also discovered and led research and development through Phase 3 for MIMRYLO™ (rusfertide), a first-in-class hepcidin mimetic peptide licensed to Takeda Pharmaceutical Company Limited for worldwide commercialization. MIMRYLO is approved in the U.S. for the treatment of erythrocytosis in adults with PV. The Company also has a number of clinical and preclinical programs based on clinically and commercially validated targets and addressing unmet medical needs, including an oral IL-17 antagonist peptide, anti-obesity dual and triple agonists, an oral hepcidin functional mimetic, and the recently announced IL-4 and amylin discovery programs. More information on Protagonist, its pipeline drug candidates, and clinical studies can be found on the Company's website at Position Summary We are looking for an experienced and hands-on HR Manager to support the day-to-day HR needs of our growing organization. This role will be responsible for a broad range of HR activities, including employee relations, benefits administration, HR operations, compliance, onboarding, performance management, and recruiting support. This is an onsite position requiring 5 days per week in the office. Responsibilities Maintain accurate and confidential employee records and HRIS data, including processing and documenting new hires, promotions, transfers, compensation and job changes, and terminations. Manage and coordinate new hire onboarding and orientation, ensuring a positive and consistent employee experience. Administer employee benefits programs, including enrollments, changes, employee communications, and ongoing benefit-related support. Serve as the primary day-to-day HR point of contact for employees and provide timely, accurate guidance on HR programs, policies, and procedures. Maintain working knowledge of federal, state, and local employment laws and regulations, including FMLA, ADA and leaves of absence. Ensure HR data integrity to support payroll, benefits administration, compliance, reporting, and other business requirements. Support HR and compliance audits and help ensure adherence to company policies and applicable regulatory requirements. Conduct periodic reviews and audits of HR processes and systems to identify opportunities for improved accuracy, efficiency, and effectiveness. Provide recruitment support as needed, including job postings, candidate screening, interview coordination, and candidate interviews. Support performance management processes, recognition programs, training initiatives, and company-wide HR events. Provide guidance and support on employee relations issues, including conflict resolution, disciplinary actions, and performance management. Handle confidential and sensitive employee information with a high level of professionalism, discretion, and sound judgment. Perform other HR responsibilities and projects as needed to support evolving business and organizational needs. Required Skills & Qualifications 5–8 years of progressive Human Resources experience, preferably within a small biotechnology, pharmaceutical, or life sciences organization. Strong working knowledge of HR best practices and applicable federal and state employment laws and regulations. Hands-on experience with benefits administration, employee relations, HR operations, and HRIS administration. Strong organizational skills and exceptional attention to detail, accuracy, and follow-through. Excellent written and verbal communication skills, with the ability to communicate effectively with employees and managers at all levels of the organization. Demonstrated ability to handle confidential and sensitive employee matters with discretion, professionalism, and sound judgment. Proficiency in Microsoft Office applications, including Outlook, Word, and Excel, and experience working with HRIS platforms. Experience with ADP Workforce Now strongly preferred. Ability to manage multiple priorities, meet deadlines, and adapt effectively to changing business needs. Self-motivated, proactive, resourceful, and collaborative, with the ability to work effectively in a hands‑on HR environment. The base pay range for this position at commencement of employment is expected to be between $135K and $165K/ year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. Benefits A top priority for Protagonist Therapeutics, Inc. is to provide a robust and comprehensive health and wellness program for our employees and their families. We offer a variety of high-quality coverage and benefit options. Health Care benefits. Protagonist covers 100% of the premium cost for medical, dental, and vision coverage for all full-time employees and their dependents. Flexible Spending Accounts – Healthcare FSA, Dependent Care FSA, Commuter Benefits 401(k) Plan Flexible Vacation Policy Life Insurance (Basic, Voluntary & AD&D) Short Term & Long Term Disability Company paid lunch and snacks #J-18808-Ljbffr