Manager, Statistical Programming

$110k - $165k

Full-time

Rhythm Pharmaceuticals

Company Overview
Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.
Opportunity Overview
Rhythm is seeking a Manager, Statistical Programming to join our Biostatistics and Statistical Programming team. This role will provide statistical programming hands-on support across clinical studies, regulatory submissions, and cross-functional development activities. The successful candidate will be responsible for delivering high-quality, compliant analysis datasets, tables, listings, and figures; contributing to study-level and integrated submission deliverables; and partnering closely with Biostatistics, Data Management, Clinical Development, Medical Writing, Regulatory, and external vendors. Depending on level, the role may also include broader responsibility for study oversight, process improvement, standards development, vendor oversight, and mentoring programmers. The level will be determined based on the candidate’s experience, technical depth, and leadership capabilities.
Responsibilities and Duties
Lead or support statistical programming activities for assigned clinical studies, including development, validation, and quality control of analysis datasets, tables, listings, and figures for study reports, regulatory submissions, and internal decision-making.
Serve as a study lead programmer or programming representative, partnering closely with Biostatistics, Data Management, Clinical Development, Medical Writing, Regulatory, and external vendors to deliver high-quality results on time.
Develop, review, and maintain ADaM specifications, TLF shells, programming documentation, reusable macros, and study-level programming standards in alignment with company procedures and regulatory expectations.
Provide input into protocols, statistical analysis plans, CRF design and annotation, edit checks, SDTM specifications, integrated data review, and submission strategy to ensure traceability, consistency, and efficient downstream analysis.
Support regulatory submission readiness, including preparation and review of define.xml, reviewer guides, submission-ready datasets, and related documentation in compliance with CDISC and global regulatory requirements.
Identify programming risks, drive issue resolution, and recommend process improvements that enhance quality, scalability, efficiency, and inspection readiness across studies and programs.
Depending on level, mentor junior programmers, provide technical guidance, contribute to resource planning, oversee vendor deliverables, and help shape departmental standards, tools, and best practices.
Qualifications and Skills
MS or equivalent degree in Statistics, Biostatistics, Mathematics, Computer Science, or a related discipline; advanced degree preferred.
5+ years relevant statistical programming experience in biotech, pharma, or CRO settings; vendor oversight experience preferred but not required.
Strong hands-on expertise in SAS programming, including Base SAS, SAS/STAT, SAS/GRAPH, SAS/SQL, SAS/ODS, and macro development; experience with R or other modern programming tools is a plus.
Deep knowledge of CDISC standards, including SDTM, ADaM, define.xml, reviewer guides, and electronic submission requirements in eCTD format.
Experience supporting study-level and integrated analyses, including ISS/ISE or other cross-study deliverables, with strong understanding of clinical trial reporting and regulatory submission processes.
Able to work independently, manage priorities, collaborate cross-functionally, and deliver high-quality work in a fast-paced environment.
For manager-level candidates, experience mentoring programmers, overseeing external vendors, and contributing to resource planning or process improvement is a plus.
This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel.
The expected salary range for this position is $110,000 - $165,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units.
More about Rhythm
We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism.

At Rhythm our core values are:
We are committed to advancing scientific understanding to improve patients’ lives
We are inspired to tackle tough challenges and have the courage to ask bold questions
We are eager to learn and adapt
We believe collaboration and ownership are foundational for our success
We value the unique contribution each individual brings to furthering our mission
Inherent in our core values is the commitment to act ethically and with integrity in all we do.
Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law.
Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.

Apply

Vacancy posted 11 days ago

Similar jobs that could be interesting for youBased on the Manager, Statistical Programming in Boston, MA vacancy

Senior Manager Statistical Programming
$150.5k - $245.5k
...science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Senior Manager, Statistical Programming to join our Statistical Programming function, providing technical leadership across project teams within one or more...
Suggested
Worldwide
Regeneron
Cambridge, MA
a month ago
Associate Director, Statistical Programming
$150k - $195k
...for rare patients. Position Summary The Associate Director, Statistical Programming works closely with the Executive Director, Statistical... ...coordinate programming activities with Biometrics lead, data managers, and other study programmers. Develops and/or reviews SAPs,...
Suggested
Temporary work
For contractors
Remote work
Shift work
Travere Therapeutics
Boston, MA
3 days ago
Executive Director, Statistical Programming
$246k - $332k
...patients . Position Summary: The Executive Director, Statistical Programming will lead the Statistical Programming function within the... ..., and security, in collaboration with IT and QA. Manage or provide oversight to third party service providers (i.e....
Suggested
Temporary work
For contractors
Remote work
Travere Therapeutics
Boston, MA
1 day ago
Manager Statistical Programming
$128.6k - $210k
...an onsite role and NOT eligible remote. A Manager provides timely support to the study team on all programming matters according to the project strategies. As... ...Requirements will be identified according to a Statistical Analysis Plan, programming specification or user...
Suggested
Permanent employment
For contractors
Work experience placement
Local area
Regeneron
Cambridge, MA
4 days ago
Manager Statistical Programming
$128.6k - $210k
..., we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Manager, Statistical Programming to join our Statistical Programming team, supporting a study team across our clinical portfolio. In this role, you will...
Suggested
Permanent employment
For contractors
Work experience placement
Worldwide
Shift work
Regeneron
Cambridge, MA
a month ago
Senior Manager, Statistical Programming
$150.5k - $245.5k
...A Sr. Manager provides timely support to the project team on all programming matters according to the project strategies within a therapeutic area. As an integral... ...requirements will be identified according to a Statistical Analysis Plan, programming specifications or user...
Local area
Regeneron
Cambridge, MA
4 days ago
Associate Director, Statistical Programming
$159k - $195k
...Associate Director, Statistical Programming Waltham, Massachusetts At Kailera, we are bold, authentic and committed to our mission of developing... ...to deliver results in a timely and accurate manner Manage multiple projects simultaneously, ensuring tasks are...
Full time
Contract work
Local area
Flexible hours
3 days per week
Kailera Therapeutics
Waltham, MA
4 days ago
Associate Director, Statistical Programming
$175k - $204k
...disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD)... ...Role Summary: The Associate Director, Statistical Programming is accountable for program-... ...Collaborate with biostatisticians, data managers, clinical operations, vendors, and other...
For contractors
Local area
Dyne Therapeutics Inc
Waltham, MA
19 hours ago
Director, Statistical Programming
$168.83k - $253.25k
...Are you an experienced Manager and Leader in Statistical Programming with a deep knowledge of clinical drug development and line management experience? Would you like to be part of a fast-paced and agile global team that has a direct strategic impact on drug development...
Hourly pay
Temporary work
AstraZeneca
Waltham, MA
3 days ago
Associate Director, Statistical Programming
$181.1k - $244.9k
The Associate Director, Statistical Programming is responsible for statistical programming activities in support of clinical trials including... ...affairs, and market access needs.Works closely with Data Management on cross-functional data review and the development and validation...
Full time
Temporary work
Local area
Flexible hours
Alnylam Pharmaceuticals
Cambridge, MA
3 days ago
Associate Director of Statistical Programming
...responsible for the design, monitoring and statistical analysis of clinical trials and... ...of Public Health have provided a strong program for growth and professional development... ...programmers as well as the CBAR Quality Management Team, IT professionals, Internal Resource...
Work experience placement
Remote work
Worldwide
Harvard University
Boston, MA
5 days ago
Technical Program Manager
...Experience, Cloud, and Infrastructure services. Find your passion and build your career with Brillio. Role: Technical Program Manager Employment Type: Permanent Location: Boston MA Role Summary Seeking an experienced Technical Program Manager (TPM)...
Permanent employment
Brillio
Boston, MA
3 days ago
Senior Program Coordinator, Sargent, Health Sciences
...Senior Program Coordinator, Sargent, Health Sciences Boston University Sargent College... ...Coordinator position is responsible for managing a wide variety of professional and... ...student-related data and compile program statistics and contribute to required reporting....
For contractors
Work at office
Flexible hours
Boston University
Boston, MA
4 days ago
Associate Director, Statistical Programming
$171.5k - $214.42k
...Multiple Sclerosis (MS). Zenas’ earlier stage programs include ZB021, a clinical-stage,... ...Position Summary:The Associate Director, Statistical Programming will independently lead and... .... The position also involves direct management and oversight of internal, contract, and...
Contract work
Flexible hours
Zenas BioPharma
Waltham, MA
5 days ago
Associate Director, Statistical Programming
$184.07k - $198.8k
The Associate Director of Statistical Programming, as a member of the Biostatistics & Statistical Programming Department, will contribute to... ...The Associate Director will combine technical and project management skills to lead programmers to develop and validate SAS programs...
Local area
Alkermes
Waltham, MA
4 days ago
Senior Technical Program Manager
$150k - $195k
...empowers members to perform at a higher level through a deeper understanding of their bodies and daily lives.As a Senior Technical Program Manager on the Manufacturing Program Management team, you’ll help scale WHOOP’s global manufacturing capabilities across New Product...
Full time
Contract work
Work at office
Relocation
WHOOP
Boston, MA
2 days ago
Technical Program Manager
...Technical Program Manager Location: Quincy, MA Hybrid Duration: 1+ Year Position Summary looking for a Technical Project Manager to lead and manage IT project tasks in support of the business-driven, customer service-oriented approach to...
Work experience placement
Work at office
Shift work
The Judge Group
Quincy, MA
19 hours ago
Senior Technical Program Manager
$90 - $120 per hour
...Overview About the Role & Team The Senior Technical Project Manager is the cross-workstream coordinator who owns the integrated NEXUS program plan at the execution layer. You hold workstream leads to their deadlines, manage dependencies across processes, architecture...
Hourly pay
Work at office
Remote work
Worldwide
Relocation
International Data Corporation
Boston, MA
19 hours ago
Technical Program Manager
$75k - $120k
...Technical Program Manager Do you want to change how the world creates? At Formlabs, we're building the tools that make it possible for anyone to bring their ideas to life, from cutting-edge products to life-saving medical devices. Our 3D printing technology powers...
Full time
Work at office
Worldwide
Overseas
Flexible hours
Formlabs
Somerville, MA
2 days ago
Technical Program Manager (TPM)
...Required: ~ Bachelor's degree in Engineering, Computer Science, or a related technical field. ~7+ years of technical program management experience, with at least 3 years managing programs that involve hardware development, physical systems, or robotics. ~ Strong...
Apolis
Boston, MA
19 hours ago
Senior Technical Program Manager
...characterized by both technical excellence and next-level collaboration and respect. The Role Tutor is hiring a Senior Technical Program Manager to own program management for the Cassie workstream. Cassie is our robot worker for pallets and cases: we have many Cassie...
Work at office
Tutor Intelligence
Watertown, MA
3 days ago
Technical Program Manager
$110.5k - $176k
...opportunities to make a real impact and grow along the way Our Opportunity: We are looking for a Senior Technical Program Manager - Healthcare B2C at our Boston, MA or Bellevue, WA office. This role will own the portfolio planning, technical coordination,...
Work at office
Local area
Flexible hours
Chewy
Boston, MA
19 hours ago
Senior Technical Program Manager
$125k - $165k
...Program Manager (CapEx) At WHOOP, we're on a mission to unlock human performance. WHOOP empowers members to perform at a higher level through a deeper understanding of their bodies and daily lives. As a CapEx Program Manager on the Technical Program Management (TPM...
Full time
Venturefizz Product Management Community
Boston, MA
2 days ago
Technical Program Manager
$165k - $185k
...Technical Program Manager Job Locations 14 hours ago(9/1/2026 5:06 PM) Job ID 2026-12280 Posted Date Project/Program Management Job Location US-MA- Company Overview We are a world-class team of professionals who deliver next...
Contract work
Work experience placement
For subcontractor
Work at office
QinetiQ U.S.
Boston, MA
4 days ago
Sr. Technical Program Manager
$131.25k - $210k
...Sr. Technical Program Manager Washington, United States Join Axon and be a Force for Good At Axon, we're on a mission to Protect Life. We're explorers, pursuing society's most critical safety and justice issues with our ecosystem of devices and cloud software....
Axon
Boston, MA
5 days ago
Senior Technical Program Manager
$83k - $166.1k
...Job Description We are currently seeking an experienced Program Manager to help manage a new internal initiative within Oracle Health and Life Sciences. In this critical role, you will help drive definition and clarity around customer excellence, specifically focusing...
Temporary work
Flexible hours
Oracle
Boston, MA
4 days ago
Senior Technical Program Manager
$127k - $157k
...We are seeking an experienced Technical Program Manager to support the growth of the world's most innovative HealthCare data platform. InterSystems HealthShare is the engine behind some of the world's most critical health applications. We are the platform technology that...
Temporary work
Worldwide
InterSystems
Boston, MA
2 days ago
CMC Statistics Director
$193.1k - $289.7k
Job DescriptionGENERAL SUMMARY:The CMC Statistics Director (Scientific Fellow) provides strategic... ...transfer activities, and lifecycle management programsSupport the application of... ...advanced statistical support for stability programs, shelf-life estimation, comparability...
Full time
Summer work
Remote work
Flexible hours
2 days per week
Vertex Pharmaceuticals
Boston, MA
5 days ago
Director - Statistics
$193.5k - $338.8k
...need them, improve the understanding and management of disease, and give back to our... ...medicines. The company’s initial three programs - VERVE-101, VERVE-102, and VERVE-201 -... ...Statistician at the Director level provides statistical leadership in multiple dimensions including...
Local area
Flexible hours
Eli Lilly and Company
Boston, MA
3 days ago
Biostatistician/Manager of Statistical Training
...responsible for the design, monitoring and statistical analysis of clinical trials and... ...of Public Health have provided a strong program for growth and professional development... ...is actively recruiting a Biostatistician/Manager of Statistical Training to act as a protocol...
Remote work
Harvard University
Boston, MA
2 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Manager, Statistical Programming. Be the first to apply!