Senior Research Associate
Meet Life Sciences
Senior Research Associate - xRNA Process Sciences Location: Watertown, MA Job Type: Full-Time | Lab & Office-Based About the Role We are seeking a motivated Senior Research Associate to join a growing Process Sciences team focused on the development and manufacturing of xRNA-based therapeutics . This role is ideal for a hands-on scientist with experience in mRNA/xRNA process development, IVT, downstream purification, and process scale-up . You will play an important role in developing, optimizing, and supporting RNA production processes from laboratory through intermediate scale, while contributing to analytical testing, troubleshooting, and technology transfer activities. Key Responsibilities Perform and support in vitro transcription (IVT) reactions at small and intermediate scales. Support IVT processes using stirred-tank and wave-based systems . Troubleshoot and optimize IVT and downstream purification processes. Perform and support chromatography-based purification of IVT-produced RNA. Execute and support AKTA-based purification processes . Perform tangential flow filtration (TFF) and related downstream processing activities. Support process development, optimization, scale-up, and technology transfer activities. Evaluate RNA purity and concentration using analytical techniques including Fragment Analyzer, NanoDrop, CE, Bioanalyzer, gel electrophoresis, and UV spectroscopy . Maintain accurate and thorough laboratory documentation in accordance with good documentation practices. Follow GLP/GMP principles, laboratory safety procedures, and applicable BSL requirements . Collaborate with cross-functional teams to support internal programs and client-facing projects. Contribute to troubleshooting, process improvement, and other activities as required. Requirements Bachelor’s degree in Pharmaceutical Sciences, Engineering, or a related discipline with 1-2 years of relevant hands-on experience, or a Master’s degree with relevant industry or academic experience. Hands-on experience with mRNA/xRNA drug substance process development and/or manufacturing processes. Practical experience with IVT and RNA process development . Experience with AKTA chromatography and purification process development/optimization . Hands-on experience with TFF , including process development, scale-up, or technology transfer. Experience with RNA characterization and analytical techniques such as Fragment Analyzer/CE, Bioanalyzer, gel electrophoresis, UV spectroscopy, or NanoDrop . Understanding of pharmaceutical/biotechnology processes and laboratory best practices. Strong troubleshooting and problem-solving abilities. Excellent written and verbal communication skills. Ability to work effectively in a collaborative, fast-paced laboratory environment. #J-18808-Ljbffr Meet Life Sciences
$90k - $120k
...Job Description Job Description Senior / Principal Research Associate, In Vivo Studies Location: Boston, MA Reports to: Scientist II Job Type: Full time, Onsite About Us We are an innovative, stealth-mode biotech focused on developing best-in-class...SeniorFull timePivotal
Cambridge, MA15 days ago$22.57 per hour
Posting Description SENIOR RESEARCH SUPPORT ASSOCIATE, Biology - Weissbourd Lab, to support ongoing projects with contributions ranging from wet lab work to computational expertise, engineering, and other fields. Examples could include: Laboratory experiments: microscopy...SeniorFull timeVisa sponsorship- Sail Biomedicines is seeking a Senior Research Associate for high-throughput RNA production to advance Endless RNA technologies. You will manage end-to-end RNA production from cloning to IVT, assess quality, and coordinate with vendors and automation teams in a fast-paced...Senior
- Moderna in Cambridge, MA seeks a Senior Research Associate to advance RNA modification biochemistry within the RNA Innovation team. The role focuses on designing experiments using in vitro biochemistry and cell line techniques to explore mRNA metabolism, with strong initiative...Senior
- Q-state Biosciences in Cambridge, MA is seeking a capable Biologist to execute and troubleshoot production and QC of neuronal cultures derived from human iPS cells for internal and client projects. You will maintain multiple iPS cell lines, differentiate them into various...Senior
- Moderna is seeking a Sr. Research Associate to join the Infectious Disease Research Immunology team in Cambridge, MA. You will design, execute, and optimize antibody binding and functional serological assays to map humoral responses across preclinical models and clinical...Senior
- Massachusetts Institute of Technology's Weissbourd Lab in Cambridge seeks a Senior Research Support Associate to support cutting‑edge biology and neuroscience research. You will conduct laboratory experiments (microscopy, cloning, RNA work), contribute to computational...Senior
- Deep Genomics is seeking a Principal Research Associate to advance our AI RNA therapeutics discovery platform. You will design and execute cell-based assays, culture mammalian cells, and analyze RNA/protein readouts as part of our internal therapeutic pipeline. The role...Senior
- Piper Companies is seeking a Senior Research Associate in Cambridge, MA to work in a preclinical biotechnology setting. You will culture human pluripotent stem cells, differentiate them, and perform molecular biology assays including RT-qPCR, ddPCR, flow cytometry, immunohistochemistry...Senior
- Piper Companies is seeking a highly motivated Senior Research Associate II to support the development of innovative cell-based therapies. This role will contribute to stem cell research, genetic engineering studies, and translational biology programs through hands-on laboratory...Senior
- Moderna is seeking a Senior Research Associate for the In Vivo Pharmacology team to support autoimmune disease programs. This vivarium-based role emphasizes immune cell modulation, pharmacodynamic assessment, and in vivo study execution with emphasis on data integrity....Senior
- Dyno Therapeutics is seeking a Senior Research Associate to advance animal studies and identify muscle AAV-based capsids. You will process tissues from in vivo studies, support histology workflows, and perform in vitro experiments to characterize leading capsids and libraries...Senior
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- ODDITY LABS in Cambridge, MA seeks a Senior Research Associate to serve as the hands-on anchor for dermatology assay workflows. You will execute, optimize, and document experiments supporting target validation, screening, and translational substantiation. You will work...Senior
- ...Biologist to join the Nucleic Acid Technology team. You will synthesize, purify, and characterize mRNA and other nucleic acids to enable research across Moderna. You will work with scientists to generate high-quality materials, apply molecular biology techniques, analyze data...Senior
$37 - $50 per hour
Piper Companies is looking for a Senior Research Associate to join a preclinical biotechnology company located in Cambridge, MA . Responsibilities of the Senior Research Associate include: Performing human pluripotent stem cell culture and differentiation experiments Conducting...Senior$75k - $95k
...programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering. The Role The Senior Research Associate, Platform RNA Sciences, will work on key projects to advance Sail’s first-in-class programmable circular RNA technology (...SeniorFull timeLocal area$75k - $95k
...programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering. The Role The Senior Research Associate, Platform RNA Sciences, will work on key projects to advance Sail's first-in-class programmable circular RNA technology (...SeniorFull timeLocal area- Senior Research Associate, Process Development Join to apply for the Senior Research Associate, Process Development role at Landmark Bio . Landmark Bio translates groundbreaking research into life-changing medicines. We provide development, manufacturing, and regulatory...Senior
$80k - $98k
..., MA. POSITION SUMMARY We are seeking a highly motivated individual to join the Analytical Development team as a Research Associate II / Senior Research Associate. This position is an excellent opportunity to help develop new gene editing and xenotransplantation...SeniorFull timeeGenesis
Cambridge, MA8 days ago$81k - $107.25k
...s scientific platforms to create novel treatment options across oncology, autoimmunity, and metabolism. Position Summary Senior Research Associate in the In Vivo Pharmacology group. Responsibilities include independently developing and performing studies with animal models...Senior- ...hematology, and immunoassays from human and animal blood samples ( We are seeking a highly motivated and broadly skilled Senior Research Associate to support development of our growing diagnostic assay menu across veterinary medicine and the in vitro diagnostics (IVD)...Senior
GENERAL FLUIDICS CORPORATION
Watertown, MA15 days ago $70k - $100k
Piper Companies is seeking a highly motivated Senior Research Associate II to support the development of innovative cell-based therapies. This role will contribute to stem cell research, genetic engineering studies, and translational biology programs through hands-on laboratory...SeniorShift workWeekend work- ...Job Description Job Description The Senior Research Associate is a key member of the growing Pharmaceutical Sciences and Technology team and is responsible for executing cell culture development activities in our laboratory and contributing to projects with our partner...SeniorContract workLocal area
Visterra
Waltham, MA15 days ago - Sail Biomedicines in Cambridge, MA is seeking a Senior Research Associate, Platform RNA Sciences to advance Endless RNA technology. You will optimize eRNA purification, improve circularization, and contribute to design through rigorous experiments and data analysis. The...Senior
$81k - $107.3k
Senior Research Associate, LNP Production Cambridge, MA USA COMPANY DESCRIPTION Mirai Bio is a privately-held, Flagship-founded biotechnology company that is delivering genetic medicines from promise to performance. Mirai was built to solve one of the field’s central...Senior- ...fast-paced, innovative, agile, and offers every team member the opportunity to drive a big impact. THE ROLE We are seeking a Senior Research Associate to be the hands-on technical anchor for dermatology assay workflows — executing, optimizing, and documenting experiments...SeniorH1bWork at officeVisa sponsorship
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- Mirai Bio is seeking a Senior Research Associate, LNP Production to design, produce, and optimize lipid nanoparticle formulations for preclinical research. This hands-on role requires expertise in LNP formulation, scale-up, and collaboration across programs. You will work...Senior
$80k - $118k
Senior Research Associate / Associate Scientist, Characterization Cambridge, MA USA Lila Sciences is seeking a Senior Research Associate / Associate Scientist, Characterization to join the Materials Science team within the Autonomous Science Platform. This role focuses...SeniorFull timeWork at officeLocal areaFlexible hours
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