Director, Translational Medicine

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody‑drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors. For more information, visit and follow the Company on LinkedIn and X. We are seeking a Director of Translational Medicine to join our team. You will provide scientific and strategic leadership for one or more programs supporting the advancement of Crescent’s pipeline focusing on next generation immuno‑oncology (I/O) and antibody‑drug conjugate (ADC). Working with cross‑functional teams, you will develop and execute the Translational Medicine strategy to help shape the clinical development plans and contribute to clinical and scientific deliverables. Responsibilities Develop and execute translational strategy to help advance Crescent’s clinical pipeline Provide oversight of the development, validation, and execution of fit‑for‑purpose clinical biomarker assays with external CROs and actively manage vendor relationships Drive clinical biomarker sample testing and data delivery in close collaboration with clinical development operations team Lead biomarker data analysis and contribute to clinical and scientific data deliverables Serve as the translational medicine lead in cross‑functional program teams and support integrated program development plans Author translational medicine sections in IND modules, clinical protocols, IBs, ICFs, and other clinical documents and technical reports, and respond to regulatory inquiries related to translational medicine Provide translational input into novel target identification Education & Experience PhD/MD in Cancer Biology, Immuno‑Oncology, Immunology, Molecular Biology, Pathology, or other scientifically related field required Minimum 8 years of industry experience in translational medicine and clinical biomarkers Experience in leading translational efforts to advance the IO and/or ADC programs from IND‑enabling phase through early phase clinical development and/or from early phase clinical development through late phase Prior experience in CDx development is a plus Strong team player with the ability to work in cross‑functional matrix Excellent interpersonal, verbal, and written communication skills What We Offer Opportunity to join a mission‑driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment Competitive compensation, including base salary, performance bonus, and equity 100% employer‑paid benefits package Flexible PTO; also, two, one‑week company‑wide shutdowns each year A commitment to your professional development, with access to resources, mentorship, and growth opportunities $230,000 - $255,000 a year Please note: The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography. Additional Description for Pay Transparency: Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s savings plan (401(k)). This position is eligible to participate in the Company’s long‑term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation – Unlimited PTO; Sick time – 10 days per calendar year; Holiday pay, including two Company shut downs; Parental Leave – 16 weeks within one year of the birth/adoption/foster care of a child; FMLA; Military Leave. Additional information can be found at Crescent Biopharma is an Equal Opportunity Employer. We are committed to fostering a diverse, inclusive, and equitable workplace where all individuals are valued and respected. Employment decisions are based on qualifications, merit, and business needs, without regard to race, color, religion, gender, sexual orientation, national origin, disability, veteran status, or any other protected status. #J-18808-Ljbffr