Principal Scientist

Build our future together: At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Principal Scientist to join our Genetic Medicines team, helping advance the preclinical development of targeted genetic medicines for disorders of the central nervous system. In this role, you will design and lead experiments across CNS disease models, working as part of a collaborative, multidisciplinary team spanning platform technology, disease biology, and early clinical development. This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide. When & where: Location: Tarrytown, NY Work model/flexibility: Onsite Discover your role: Design experiments to evaluate the efficacy, target engagement, and delivery efficiency of viral and non-viral therapeutic candidates across CNS disease models Design AAV transgene cassettes to optimize therapeutic efficacy Lead a team of associates in the execution of experiments and analysis of primary data Interpret complex datasets, integrating findings with current scientific literature to propose data-driven next steps Communicate project strategy, scientific vision, and data updates to senior leaders Author and review preclinical study reports to support regulatory submissions Approach scientific problems with an engineering mindset and a design-build-test-learn framework Coach and mentor junior scientists within a multidisciplinary team environment This role requires: Experience evaluating DNA- or RNA-based therapeutics in small-animal models Hands‑on experience with molecular biology techniques Experience mentoring and managing research associates Excellent communication and presentation skills Preferred: Ph.D. in neuroscience, gene therapy, or a related discipline Preferred: 5+ years of combined postdoctoral and industry experience in biotechnology, genetic medicines, or CNS drug discovery Preferred: knowledge of both viral and non-viral genetic medicine delivery modalities We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit For other locations, additional information will be provided during the recruitment process. Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on-site. As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications. For jobs in Canada: this posting is for an existing position. Salary Range (annually) $128,600.00 - $210,000.00 #J-18808-Ljbffr Regeneron Pharmaceuticals