Senior Associate Scientist Purification Process Development

Job Title: Senior Associate Associate - Purification Process DevelopmentLocation: Waltham, MAAbout the Job:The Genomic Medicine Unit (GMU) in Sanofi is responsible for the design and optimization of viral vector manufacturing processes and platforms. This organization encompasses vector and cell line engineering, upstream and downstream process development, analytics, and clinical manufacturing support.The GMU purification process development group is responsible for the development of AAV and non-viral vector processes and for supporting viral vector purification from next-generation production platforms to enable high-dose gene therapy programs. The Senior Research Associate (SRA) – Downstream Process Development role requires leadership both inside and outside the laboratory and will rely on industry expertise and the exploration of novel technologies in order to build robust and efficient purification processes consistent with patient safety standards.We are looking for a candidate with experience in AAV and/or non-viral purification development, scale-up and manufacturing, and technology transfer.Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.About Sanofi:We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.Main Responsibilities:Support to develop, design and conduct viral vector purification experiments and evaluate new technologies to increase product yield and process understandingDevelop, maintain and demonstrate advanced knowledge of principals and techniques in column chromatography and other areas of downstream purificationMaintain industry knowledge and awareness of new and relevant technologies, and be willing to publish findings and to speak both internally and externally as industry leadersLead / support development of study design, optimization of purification process conditions, media screening and perform troubleshooting experiments and communicate findings with appropriate working groupsPerform data analyses, contribute to technical reports and internal/external presentationsSupport scale-up activities to implement a manufacturing process based on applied DSP knowledgeCommunicate effectively with internal and external teams, e.g. CDMOs for tech transfer activitiesContribute to manuscript and patent writing for external publications and patent applications, respectivelySelf-motivated and display sound technical judgementBuild a culture of support and collaboration among colleaguesAbout you:Basic QualificationsEducation:Bachelor's OR Master's degree in: Chemical Engineering, Biological/Life Sciences, or a related fieldExperience:Bachelor's holders: 2+ years of experience in laboratory or related settingsMaster's holders: 6+ months of experience in laboratory or related settingsAcademic or research experience will be considered.Knowledge of purification technologies and operations such as: Depth filtration, AKTA, automated protein purification chromatography, tangential flow filtration, UF/DF, virus clearance and inactivation or filtration unit operations at various scales.Understanding of chromatography principles and separation methodsTechnical report writing skillsAbility to learn and perform viral vector analyses using new tools and techniquesGood laboratory practices (GLP), including detailed lab notebook documentationPreferred QualificationsExperience specifically with AAV and/or non-viral vector purificationKnowledge of analytical tools: spectrophotometry, ELISA, HPLC, and SDS-PAGEFamiliarity with Quality by Design principles and ability to apply Design of Experiments (DOE) to downstream developmentUnderstanding of virus clearance study design and executionExperience with large-scale manufacturing unit operationsExperience with process technology transfers, gap analyses, and risk assessmentsBiosafety Level 2 lab experienceAbility to work under minimal supervisionStrong organizational and communication skills (verbal and written)Ability to build cross-functional relationships and represent the team in multi-functional meetingsCollaborative, team-oriented mindsetAbility to stand and work with lab bench equipment for extended periodsWhy Choose Us?Bring the miracles of science to life alongside a supportive, future-focused team.Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.Help improve the lives of millions of people globally by making drug development quicker and more effective.Sanofi US Services and its U.S. affiliates are