Director, HR Business Partner

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal's medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

This HRBP (Director level) is focused on driving critical initiatives such as workforce planning, employee engagement, performance management, and leadership coaching to support Madrigal's strategic objectives. The position plays a pivotal role in building a high-performance culture by aligning HR programs with the company's core values-Focus on Patients, Owner Mindset, Innovation, and Collaboration.

Key responsibilities include building strong, collaborative relationships with leaders, driving impactful HR initiatives, addressing complex employee relations issues, and enhancing organizational culture and employee engagement to deliver measurable results.


Reporting to the Executive Director, HR Business Partnering, this HRBP will support assigned business groups in the Commercial organization as well as other groups as assigned. This role will develop and implement HR strategies that align with the organization's business objectives and support a high-performance culture.

Position Responsibilities:

• Establish trusted, collaborative, and responsive relationships with leaders across the organization, understanding their strategies, priorities, and goals to shape impactful HR programs and priorities that align with Madrigal's core values.
• Lead key HR initiatives, including workforce planning, talent acquisition, employee relations, employee engagement and retention, learning & development, and succession planning, with measurable outcomes in mind.
• Coach and develop managers to strengthen their management and leadership skills, fostering high-performing and collaborative teams.
• Implement and manage performance management programs that align with Madrigal's high-performance culture, driving accountability and growth.
• Coach to managers and partner with Employee Relations team on ER issues in alignment with Company culture and policies.
• Collaborate across HR functions to implement tailored HR programs that address dynamic organizational needs and priorities.
• Contribute to HR projects and initiatives on an as-needed basis to drive organizational and operational success. Establish trusted, collaborative, responsive, and influential relationships with leaders across the organization, understanding their strategies, priorities, and goals. Utilize this business knowledge to shape HR programs and priorities.

Qualifications and Skills

• Bachelor's degree in human resources management (or related field) is required. Graduate degree highly preferred
• 10+ years of progressive HR Business Partner experience, with expertise in organizational effectiveness, change management, learning and development, and talent management.
• At least 2 years supporting field commercial teams in pharma or biotechnology companies.
• At least 3 years of experience supporting or building HR functions within biotech or pharmaceutical organizations and a demonstrated understanding of HR operating models in small to mid-size environments.
• Highly organized with exceptional attention to detail, ensuring clarity, accuracy, and precision in work.
• Analytical mindset with the ability to interpret data, identify trends, and translate insights into actionable recommendations.
• Proficiency in Workday and Microsoft Office Suite (Word, Excel, PowerPoint, Outlook).
• Demonstrated consultative style with experience supporting employees and management at all levels.
• Excellent communication skills, both verbal and written, with the ability to convey complex ideas clearly and concisely.

• Ability to travel up to 20%.

Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate's qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $203,000 - $249,000 per year. We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.


Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.


We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact View email address on click.appcast.io.


Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.


Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.


Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.


Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals' Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal's name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.


Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to View email address on click.appcast.io.