Lead Structural Biologist for Drug Discovery & CryoEM

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. Diversity at Altos Altos Labs has been named one of the Top 3 Biotech Companies and ranked for the second year on the Forbes 2026 Best Startups in America list. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment. What You Will Contribute To Altos As a Structural Biology Senior Scientist at Altos Labs, you will be at the forefront of innovative research in understanding the molecular mechanisms of disease with a focus on aging and rejuvenation. Your role will involve leading the protein biochemistry and structural biology function within the Institute of Medicine and applying these techniques to support our large- and small‑molecule drug discovery portfolio. In addition, you will contribute to a strong culture of trust and teamwork, modeling the Altos Labs behaviors. Responsibilities Lead experimental structural biology and protein biochemistry within the Institute of Medicine Develop and execute structural biology strategies (expression system, purification, structure determination method, etc.) to advance the Altos discovery portfolio from early target validation through lead optimization Collaborate with our in‑house cryoEM core facility and CRO-based crystallographic facilities to deliver high‑impact macromolecular structures Work collaboratively with cross‑functional scientists to enable structure‑based design on discovery programs across different modalities Represent structural biology and protein biochemistry on cross‑functional project teams, and contribute to building and progressing the pipeline Manage external research activities conducted by CROs and collaborators Mentor and supervise junior scientists and technicians Who You Are Minimum Qualifications PhD in Structural Biology, Biochemistry, Biophysics, or a related discipline 6+ years of experience in biotech or the pharmaceutical industry supporting structural biology efforts in large- or small‑molecule drug discovery programs Proven track record of high‑resolution structure determination using X‑ray crystallography or cryoEM Experience managing external CRO activities supporting protein production, X‑ray crystallography, and cryoEM structure determination. Strong leadership, collaboration, and communication skills Preferred Qualifications Demonstrated expertise in protein engineering or structure‑guided protein design Familiarity with structure‑based drug design workflows and collaboration with medicinal/computational chemistry groups Experience developing strategy for structurally intractable targets Experience using structure prediction tools (e.g., AlphaFold, RosettaFold, Boltz) in an applied drug discovery setting Ability to communicate the nuances of protein biochemistry to non‑specialist stakeholders and executive leadership, ensuring alignment on project milestones Experience in people management The salary range for Redwood City, CA: Senior Scientist I, Structural Biology : $172,400 - $221,000 Exact compensation may vary based on skills, experience, and location. Equal Opportunity Employment Altos Labs provides equal employment opportunities to all employees and applicants for employment, without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Altos prohibits unlawful discrimination and harassment. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training. #J-18808-Ljbffr Altos Labs