TEMP - Scientist, Bioconjugation Purification
Neurocrine Biosciences
- # TEMP - Scientist, Bioconjugation PurificationApplyremote type: On-Sitelocations: US CA San Diegotime type: Full timeposted on: Posted Yesterdayjob requisition id: R6894## Who We Are:Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis\* and uterine fibroids\*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. (*\*in collaboration with AbbVie*) ## About the Role:The Scientist, Bioconjugation Purification, will support the discovery and development of novel antibody-based therapeutics through the purification, characterization, and formulation of antibodies and bioconjugates. This role is responsible for designing and executing purification strategies for complex antibodies and emerging bioconjugate modalities, including antibody-drug conjugates (ADCs), antibody-peptide conjugates (APCs), and antibody-oligonucleotide conjugates (AOCs). The successful candidate will leverage expertise in protein purification, chromatography, analytical characterization, and data interpretation to deliver high-quality materials that enable downstream research and development activities. Working in a collaborative, cross-functional environment, the Scientist will contribute to advancing innovative therapeutic programs from discovery through preclinical development.\_## Your Contributions (include, but are not limited to):* Design, execute, and optimize purification processes for antibodies and bioconjugates using a variety of chromatographic and filtration techniques* Purify and formulate antibodies, ADCs, APCs, AOCs, and related bioconjugate modalities to support discovery and preclinical development activities* Characterize purified products using established analytical methods and interpret data to assess product quality, purity, identity, and conjugation attributes* Analyze experimental results, troubleshoot technical challenges, and recommend process improvements to enhance product recovery, purity, and overall process performance* Generate, organize, and communicate scientific data through technical reports, presentations, and electronic laboratory documentation.* Collaborate effectively with scientists across bioconjugation, protein engineering, analytical, and other cross-functional teams to support project objectives* Evaluate and implement new purification and characterization technologies to improve workflow efficiency and product quality* Maintain accurate laboratory records, batch documentation, and inventory in accordance with company procedures and quality standards* Comply with all safety, quality, and operational requirements while contributing to a productive and collaborative laboratory environment* Maintain responsibility for the storage, inventory management, tracking, and distribution of antibodies, bioconjugates, and precursor materials, ensuring compliance with established procedures and supporting efficient execution of research programs* Manage laboratory inventories of consumables, reagents, and chemicals, and coordinate procurement activities in accordance with departmental procedures and established guidelines to ensure efficient laboratory operations## Requirements:* BS/BA degree in biology and 2+ years of relevant experience OR* MS/MA degree in biology and some relevant industry experience preferred OR* PhD or equivalent and some relevant experience* Knowledge of the principles of Biology, Biochemistry, Molecular Biology, Chemical Biology, Bioengineering, or related field* Demonstrated experience in purification of monoclonal/complex antibodies, antibody fragments, recombinant proteins, and/or bioconjugates and understanding of scale-up principles* Knowledge of protein chemistry, antibody structure-function relationships, and bioconjugation principles is a plus* Hands-on experience in preparative and analytical chromatography techniques including affinity chromatography, ion exchange chromatography (CEX and AEX), Hydrophobic interaction chromatography (HIC), size exclusion chromatography (SEC) and mixed-mode/multimodal chromatography* Experience operating and troubleshooting chromatography systems such as ÄKTA Pure, ÄKTA Avant, or equivalent systems* Proficiency with tangential flow filtration (TFF), ultrafiltration/diafiltration (UF/DF), and buffer exchange processes* Experience characterizing proteins and bioconjugates using analytical methods including: SEC-HPLC, HIC-HPLC for DAR determination, Reverse-phase HPLC, UV-Vis spectroscopy, endotoxin testing (LAL or equivalent)* Familiarity with analytical mass spectrometry for intact mass, subunit analysis, and conjugate characterization a plus* Demonstrated ability to analyze, interpret, and present complex purification and characterization data* Experience maintaining laboratory notebooks, batch records, SOPs, and technical reports in compliance with quality standards* Strong organizational skills with the ability to manage multiple projects and competing priorities simultaneously* Ability to independently design experiments, troubleshoot technical issues, and recommend process improvements* Ability to evaluate emerging purification and characterization technologies and implement novel approaches where appropriate* Demonstrated scientific rigor, attention to detail, and commitment to data integrity and reproducibility* Demonstrated ability to maintain a clean, organized, and efficient laboratory environment while managing multiple priorities* Collaborative team player who builds positive working relationships across functional groups and contributes to a productive team culture* Demonstrated ability to work effectively in a highly interactive, fast-paced research environment* Strong sense of ownership, accountability, and follow-through in completing assigned responsibilities* Adaptable and receptive to feedback, with a continuous improvement mindset and eagerness to learn new techniques and technologies* Proactive, approachable, and engaged, with a willingness to actively participate in scientific discussions and team activities
- J-18808-Ljbffr Neurocrine Biosciences
Vacancy posted 15 hours ago
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