IPSC Core Research Associate

Overview Reporting to the iPSC Core Scientific Director/Chair of Neuroscience and taking day‑to‑day direction from the Lead iPSC ARS, this position will work on development and support of iPSC Core‑led projects with others in the Neuroscience and Alzheimer’s Disease Research Center. The role involves organizing and maintaining multiple end‑user requests across the Neuroscience community, including CRISPR screens and high‑throughput screens of neuronally differentiated iPSC cells. The incumbent will also assist in developing new products/processes with the leadership of the iPSC and will prepare extracts for RNA profiling. Required Skills and Abilities Demonstrated experience with cell culture, including cell treatments, feeding and splitting. Excellent oral and written communication skills to interact with internal and external stakeholders, including research staff, study sponsors, and collaborators. Strong organizational skills with attention to detail, ability to manage multiple projects simultaneously, and prioritizing tasks effectively in a fast‑paced environment. Demonstrated ability to perform independent research, analyze and interpret experimental data, and contribute to scientific reports and publications. Ability to work well as part of a team, provide instruction and guidance, and contribute to the overall objectives of the research projects. Preferred Skills and Abilities Experience with CRISPR screens in iPSC cells. Experience with high‑throughput screens of neuronally differentiated iPSC cells. Experience with automated high‑content cellular immunofluorescent measurements, including Molecular Dynamics ImagExpress or equivalent. Preparation of cellular extracts for RNA profiling experiments and for immunoblot. Proven experience in maintaining, expanding and neuronally differentiating human induced pluripotent (iPSC) cells in tissue culture. Background in molecular biology, chemistry, genetics, or physical sciences with experience in techniques such as PCR, sequencing, microscopy. Takes direction well, works independently with limited supervision, and has excellent communication skills (verbal and written). Demonstrated ability to prioritize and organize competing priorities and meet deadlines. Principal Responsibilities Recommend the design and implementation of procedures and protocols under the direction of a higher‑level authority. Investigate, analyze, and reach preliminary scientific conclusions related to research planning. Ensure data results are compiled, analyzed, and presented properly. Analyze, develop, and interpret scientific results; maintain clear documentation of results; prepare scientific reports and papers for research proposals and published reports. Perform independent research and laboratory techniques and participate in experimental research planning. Interact with internal contacts—including the PI, research assistants, graduate students, Radiation Safety and Biological Safety officers, and Animal Care personnel—to discuss and evaluate research results and to ensure the smooth and safe operation of the laboratory. Interact with external contacts such as researchers at other institutions, staff at biotechnology and reagents companies to consult on research methods and to keep abreast of product information and developments. May perform other duties as assigned. Required Education and Experience Master’s Degree in a scientific discipline and one year experience or an equivalent combination of education and experience. Equal Employment Opportunity The University is committed to basing judgments concerning the admission, education, and employment of individuals upon their qualifications and abilities and seeks to attract to its faculty, staff, and student body qualified persons from a broad range of backgrounds and perspectives. In accordance with this policy and as delineated by federal and Connecticut law, Yale does not discriminate in admissions, educational programs, or employment against any individual on account of that individual’s sex, sexual orientation, gender identity or expression, race, color, national or ethnic origin, religion, age, disability, status as a special disabled veteran, veteran of the Vietnam era or other covered veteran. Inquiries concerning Yale’s Policy Against Discrimination and Harassment may be referred to the Office of Institutional Equity and Accessibility (OIEA). Other Policies Yale University is a tobacco‑free campus. #J-18808-Ljbffr Yale Cancer Center