Principal Investigator

Job Description

Job Description

Position: Principal Investigator

Salary Range: $200 - $285k

Location: Baltimore, MD, On-site

About Pharmaron

Pharmaron is a global contract research and manufacturing organization (CRO/CDMO) helping pharma and biotech companies bring new therapies to life. With over 25,000 employees worldwide across 28 locations in the US, UK, China, and Singapore, we support drug discovery through to manufacturing with fully integrated high-quality services.

We're proud of the impact we make and just last year, we supported 887 discovery projects, 1,100+ CMC programs, and 1,397 clinical trials across all phases. Our teams are involved in everything from small molecules, ADC's, biologics, and gene therapies and we work with more than 3,300 global customers. To learn more, visit

What You'll Do

As Principal Investigator , you'll provide medical and scientific leadership across clinical studies, working alongside a multidisciplinary team of research professionals, sponsors, and scientific experts.

Medical Leadership & Participant Safety

• Serve as Principal Investigator or Sub-Investigator for Phase I–III clinical trials.
• Provide medical oversight throughout study conduct, prioritizing participant safety and well-being.
• Review participant eligibility, medical histories, adverse events, and clinical safety data.
• Perform physical examinations and medical assessments as needed.
• Support dosing activities and ongoing medical monitoring.

Clinical Research & Scientific Collaboration

• Collaborate with sponsors and internal teams on protocol review, study design, and implementation.
• Provide medical and scientific guidance throughout the study lifecycle.
• Contribute to clinical data interpretation, study reporting, and regulatory submissions.
• Serve as a trusted medical resource for project teams and clients.

Regulatory Compliance & Quality

• Ensure clinical studies are conducted in accordance with ICH-GCP, FDA regulations, and applicable guidelines.
• Maintain protocol integrity and fulfill Principal Investigator oversight responsibilities, including those outlined in FDA Form 1572.
• Support regulatory inspections, audits, and agency interactions as needed.

Team Development & Collaboration

• Mentor and provide guidance to Clinical Research Coordinators, nurses, and other clinical research professionals.
• Foster a culture centered on participant safety, quality, accountability, and operational excellence.
• Work closely with Medical, Clinical Operations, Pharmacy, Laboratory, and Business Development teams.

What we're looking for:

Required Qualifications

• MD or DO from an accredited medical school.
• Board certification in a recognized medical specialty.
• Active, unrestricted medical license.
• At least 5 years of clinical practice experience.
• Current CPR and ACLS certifications.
• Strong clinical judgment and a solid understanding of patient care and medical ethics.
• Excellent communication, collaboration, and leadership skills.

Preferred Qualifications

• Previous clinical research experience as a Principal Investigator, Sub-Investigator, or treating physician.
• Experience with Phase I studies or early clinical development programs.
• Familiarity with ICH-GCP, FDA regulations, and clinical trial operations.
• Active DEA registration.
• Background in Internal Medicine, Family Medicine, or Emergency Medicine.

Why Pharmaron?

Pharmaron is a premier service provider for the life sciences industry. Founded in 2004, Pharmaron has invested in its people and facilities and established a broad spectrum of research, development, and manufacturing service capabilities throughout the entire drug discovery, preclinical, and clinical development process across multiple therapeutic modalities, including small molecules, biologics, and CGT products. With over 25,000 employees and operations in the US, UK, China, and Singapore. Pharmaron has an excellent track record in delivering R&D solutions to its partners in North America, Europe, Japan, and China.

Collaborative Culture: You will thrive in our inclusive and collaborative environment, where teamwork and innovation go hand in hand. Here, your voice matters, and your contributions make a real impact. "Employees Number One" and "Clients Centered" are the core cultural values at Pharmaron. Our culture, which sets Pharmaron apart from other organizations, has evolved from our deep commitment to our employees, partners, and collaborators.

Benefits: As part of our commitment to your well-being, we offer a comprehensive benefits package:

• Comprehensive Medical, Dental & Vision Insurance with significant employer contributions
• 401(k) Retirement Plan with generous employer matching
• Generous Paid Time Off (PTO), Paid Sick Leave & Company Holidays to support work-life balance
• Employer-funded Health Savings Account (HSA) contributions (for eligible plans), plus Healthcare & Dependent Care Flexible Spending Accounts
• 100% Employer-paid Employee Life Insurance, AD&D, Short- and Long-Term Disability Insurance
• Employee Assistance Program (EAP), mental health resources, and wellness programs
• Family-friendly benefits, including fertility support and maternity resources
• Professional development and career growth opportunities within a leading global CRO/CDMO

How to Apply:

Ready to seize this incredible opportunity? Join us at Pharmaron and be part of a dynamic team driving innovation and excellence in biopharmaceutical research and development. Apply online today!

As an Equal Employment Opportunity and Affirmative Action employer, Pharmaron values diversity and inclusion in the workplace, fostering an environment where all individuals are empowered to succeed. Join us in our mission to make a difference in the world of life sciences.

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