Senior Scientist II, Biophysics and Protein Sciences

Revolution Medicines seeks a Senior Scientist II in Biophysics and Protein Sciences to lead biophysical characterization efforts supporting oncology drug discovery. The role involves designing experiments to validate targets, confirm hits, and optimize leads through orthogonal biophysical approaches, with close collaboration across structural biology, chemistry, and assay development teams.

Responsibilities

• Serve as biophysical subject matter expert on multidisciplinary discovery teams guiding target validation and screening strategies
• Design and execute experiments characterizing protein quality, binding mechanisms, kinetics, thermodynamics, and complex formation
• Develop orthogonal biophysical strategies to accelerate hit confirmation and mechanistic understanding
• Build and optimize workflows assessing recombinant protein quality and stability for downstream applications
• Evaluate emerging biophysical technologies and communicate findings across functional teams

Requirements

• Ph.D. in Biophysics, Biochemistry, Structural Biology, or related field
• 8+ years of industry experience in drug discovery
• Expertise in quantitative biophysical experimental design and data interpretation
• Proficiency with solution-based biophysics techniques for protein characterization
• Experience characterizing weak, transient, and cooperative protein interactions
• Scientific judgment in selecting appropriate methodologies for discovery questions