Principal Scientist, Lab Platform Disruptive Technologies
$194.1k - $305.6kFull-time
Merck & Co.
Job Description We are on a quest for cures and are committed to be the world's premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines. - Discovery Biologics Disruptive Technologies is seeking a - talented and experienced scientist - to lead the development and deployment of - next-gen - lab-based experimental - technologies - to - enable rapid, data-driven biologics discovery. - This individual will identify and translate emerging, literature-supported technologies into scalable internal capabilities, with a focus on - multiplying - both the scale and speed of quantitative data generation (e.g., - binding - measurements) - to advance therapeutic programs via - GenAI/ ML-driven discovery and - iterative design-make-test - cycles. The role includes leading a team - with expectation for strong - hands-on contribution to method development, and - will be - accountable for driving measurable program and broader organizational impact. - The role is based out of our Cambridge, MA facility.-- - - Key Responsibilities -
Antibody Drug Conjugates (ADC), Biodesign, Detail-Oriented, Emerging Technologies, Ethical Compliance, Gene Cloning, Gene Expression Analysis, Immunochemistry, Leadership Engagement, Mass Spectrometry Analysis, Microscopy Techniques, Project Leadership, Protein Engineering, Protein Interactions, Protein Purifications Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts The salary range for this role is
$194,100.00 - $305,600.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits.- Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at . You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.- Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
No Travel Requirements:
10% Flexible Work Arrangements:
Not Applicable Shift:
1st - Day Valid Driving License:
No Hazardous Material(s):
N/A Job Posting End Date:
09/11/2026
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R407843
- Develop - and mature - rapid , quantitative and - high-throughput - lab-based capabilities for - biologics hit identification an d optimization -
- Build and execute - a - technology - platform - roadmap - for arrayed and pooled technologies, - from proof-of-concept through widespread - program adoption -
- Partner effectively with - computational - protein engineering and data science groups - toward - efficient, - integrated - next-gen discovery - workflows -
- Drive capability improvements in - data richness, speed , throughput - -
- Lead a - talented - team of - lab-based - scientists -
- As a hands-on individual contributor, realize and maximize - program impact of emerging technologies -
- Collaborate - effectively - across geography and reporting lines- -
- Establish - rigorous - benchmarks - (e.g. - throughput, - speed, - reproducibility , - data quality ) - and success criteria -
- PhD in Biochemistry, Bioengineering, Chemical Biology, or related field with - 7+ years - directly relevant - industry experience ; MS or BS with 12+ years industry experience. -
- Experience developing - large-scale, - high throughput - quantitative - experimental - methods - for biologics discovery -
- Experience - translating published or externally developed methods into - demonstrably - valuable - internal capabilities -
- Proven leadership track record -
- Demonstrated expertise advancing validated assays and methods toward broad organizational impact -
- Deep hands-on - expertise - in one or more of:- -
- Quantitative p ooled - binding - assays - (10k+ sequences) -
- Rapid and high throughput advanced endpoint assays ( e.g. - cell-based function, - stability, localization, etc)- -
- Lab-on-chip technologies - and protein arrays -
- M icrofluidics -
- Proven - succes s in - l eadership , - talent development - and mentorship -
- Strong understanding of biochemistry and biophysical characterization methods -
- Cross-function project leadership track record -
- Strong ability to collaborate across reporting lines, especially with protein engineers and data scientists -
- Strong demonstrated understanding of protein structure-function relationships -
- E xperience applying in - vitro transcription and translation (IVTT) -
- Direct experience in b iophysical - protein characterization -
- Therapeutic high throughput pre-developability and developability assessment -
- Automation and scalable experimental workflows -
- Experience in - workflows leveraging generative AI ML -
Antibody Drug Conjugates (ADC), Biodesign, Detail-Oriented, Emerging Technologies, Ethical Compliance, Gene Cloning, Gene Expression Analysis, Immunochemistry, Leadership Engagement, Mass Spectrometry Analysis, Microscopy Techniques, Project Leadership, Protein Engineering, Protein Interactions, Protein Purifications Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts The salary range for this role is
$194,100.00 - $305,600.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits.- Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at . You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.- Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
No Travel Requirements:
10% Flexible Work Arrangements:
Not Applicable Shift:
1st - Day Valid Driving License:
No Hazardous Material(s):
N/A Job Posting End Date:
09/11/2026
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R407843
Vacancy posted 3 days ago
Similar jobs that could be interesting for youBased on the Principal Scientist, Lab Platform Disruptive Technologies in Cambridge, MA vacancy
$143k - $214.5k
...solutions through precision technologies that ensure environmental safety... ...an innovative and strategic Principal Scientist, Molecular Cloning... ...that accelerate discovery, platform development, and product advancement... ...and its affiliated Flagship Lab companies (collectively, “...PlatformPrincipal- Overview Principal Scientist, Library Technologies Lila Sciences is the world’s first scientific superintelligence platform and autonomous lab for life, chemistry, and materials science. We are pioneering a new age of boundless discovery by applying AI to every aspect of...PlatformPrincipal
$71.25k - $187k
...our pioneering circular RNA technology, developed at MIT, we are at... ...art expression and delivery platform positions us to tackle complex... ...an exceptional Senior Principal Scientist to join our growing team. In... ...this job are consistent with lab environment Work Environment...PlatformPrincipalFull timeH1bVisa sponsorshipWork visaFlexible hours$145.5k - $218.3k
...DescriptionGeneral Summary:The Principal Scientist Aseptic Control is... ...low bioburden processing technologies and providing technical support... ...actions to prevent future disruptions. Strong collaboration in... ...products in novel device platforms; this includes working closely...PlatformPrincipalFull timeContract workSummer workRemote workFlexible hours2 days per week$146.26k - $184.71k
...ophthalmology and biotechnology platforms to deliver innovative... ...a critical role in disrupting the treatment paradigm... ...manufacturing technologies, people and organizational... ...molecules.Strong lab skills with a Can-Do attitude... ...in the Industry: Sr Scientist I:PhD: at least 5...PlatformFlexible hours- ...computational protein design and proprietary technologies that yield biological data sets at... ...is seeking an experienced Principal Scientist to help establish and advance our analytical... ...applications, and data visualization platforms) to improve scientific productivity,...PlatformPrincipalFull timeLocal area
Synolo Therapeutics
Cambridge, MA21 days ago - ...digital-first brands to disrupt the offline-dominated... ...its AI-driven online platform, deploying data science... ...METHODIQ. ODDITY LABS is our cutting-edge biotechnology... ...patented, proprietary technologies and capabilities,... ...are seeking a Senior Scientist to own translational...PlatformWork at office
$179k - $236k
...accomplished DMPK and bioanalytical scientist with experience in PK study... ...tRNAs to evaluate delivery technologies (LNP and others) and... ...and qualify CRO and external lab partners across bioanalytical... ...assays and multiplex immunoassay platforms (e.g., MSD, Luminex) for cytokine...PlatformPrincipal$120k - $140k
...ODDITY is a consumer tech platform transforming the... ...market. We deploy advanced technology, including molecular... ..., are rapidly disrupting the offline‑dominated... ...growth and impact. ODDITY Labs is our cutting‑edge biotechnology... ...to hire a Senior Scientist - Biology for ODDITY...PlatformFull timeWork at officeShift work- Senior Scientist - Immunology and Inflammation Senior... ...ODDITY is a consumer tech platform transforming the... ...market. We deploy advanced technology, including molecular... ...SpoiledChild, are rapidly disrupting the offline-dominated... ...and impact. ODDITY Labs is our cutting-edge biotechnology...PlatformFull timeContract workPart timeH1bWork at officeVisa sponsorshipShift work
$163k - $214.5k
Company SummaryFL130 (Flagship Labs 130) is an early-stage... ...recruiting a team of top-tier scientists to help build it. This is a unique... ...that invents and builds platform companies, each with the potential... ...and highly collaborative Principal Scientist to design, stand up...PlatformPrincipal$146k - $236k
...from capability to impact by leveraging PI technologies to take on translational challenges... ...returning insights that improve the AI platform. The successful candidate will reduce the... ...Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept...PlatformPrincipal- Terrana Biosciences, Inc. in Cambridge, MA is seeking a Principal Scientist, Molecular Cloning Technologies to lead cloning strategy, construct generation, and scaling across the company. You will shape capabilities that accelerate discovery and product advancement, serving...PlatformPrincipal
$108.5k - $201.5k
...-OnsiteInternal job title: Principal Scientist ILocation: Cambridge, United... ...BMD and external partner labs to ensure high-quality and... ...implement innovative assay technologies and workflows to improve assay... ...RNA-seq or related platforms.Strong understanding of circulating...PlatformPrincipalFull time$142.5k - $256.5k
...experienced, and highly motivated Principal Scientist to build, optimize, and... ...of scalable experimental platforms to improve key TCR... ...candidates through iterative wet-lab and computational optimization... ...workflows using display technologies and directed evolution approaches...PlatformPrincipalPermanent employmentFull timeWork at officeWork from home$216k - $297k
...for a team of talented machine learning scientists innovating on model architectures that will... ....Build the engine for a novel science platform: develop and integrate reasoning engines... ...Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not...PlatformPrincipal$160k - $190k
...Position The Principal Scientist, Analytical Chemistry will report directly to the Director of Oligonucleotide... ...an efficient and timely manner. As a lab‑based role, this person will implement... ...evaluation in our targeted delivery platform. Develop and implement QC methods to...PlatformPrincipalRaven Healthcare Incubator (RA Capital)
Boston, MA3 days ago$208k - $286k
...and beyond. THE ROLE We are seeking a Principal Scientist (Embedded ML/Computational) to lead AI/... ...Pioneering Medicines (PM) and across Flagship’s platform companies as part of the company... ...Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not...PlatformPrincipal- ...Principal Scientist, mRNA-tLNP Analytical Development Principal Scientist, mRNA-tLNP Analytical... ...and targeted lipid nanoparticle (tLNP) technology. By developing in vivo CAR-T therapies... ...methods to support the company’s mRNA platform for in vivo CAR-T programs. This role...PlatformPrincipalFlexible hours
Kernal Biologics Inc.
Boston, MA4 days ago - ...seeking an experienced, highly motivated Principal Associate Scientist to validate therapeutic gene targets... ..., targeted siRNA delivery platforms across multiple pipeline programs and... ...preclinical models preferredExcellent lab technique and demonstrated ability to...PlatformPrincipalFull timeTemporary workWork experience placementLocal areaFlexible hours
$122.25k - $176.58k
...R2857588 Job title : Principal Scientist ~ Location: Waltham, MA... ...best-in-class manufacturing platforms to support development of life... ...bioreactor operations and scale-up technologies. Experience in the... ...teams for operations and lab management. Preferred Qualifications...PlatformPrincipalFull timeSanofi Group
Watertown, MA23 hours ago$144.65k - $216.97k
...an experienced and visionary Associate Principal Scientist to lead Biologics AI innovation at AstraZeneca... ...‑of‑the‑art machine learning with wet‑lab discovery to accelerate biologics... ...utility and reproducibility; influence data platform evolution in collaboration with...PlatformPrincipalFull timeTemporary work$121.28k - $202.13k
...of the immune system with cutting-edge technology to transform people’s lives. GSK fosters... ...Translational Science is seeking a Translational AI scientist to build ML applications for a long-... ...clinical data.Partner closely with wet-lab scientists, clinicians, and pathologists...PrincipalFull timeWork at officeLocal areaRemote workRelocation$126k - $181.5k
...companies that invent breakthrough technologies in order to transform health... ...and sustainability? Flagship Labs 129 (FL129) is an early-stage biotechnology... ...recruiting a team of top-tier scientists to build this powerful and first-in-category platform. This is a unique opportunity...PlatformContract work$126k - $181.5k
Company SummaryFL130 (Flagship Labs 130) is an early-stage... ...recruiting a team of top-tier scientists to help build it. This is a unique... ...that invents and builds platform companies, each with the potential... ...and surface display technology to help build a novel platform...Platform$126k - $181.5k
...companies that invent breakthrough technologies to transform health care? In... ...be most impactful. Flagship Labs 103, Inc. is a privately held... ...and computational platforms to pioneer the detection of cellular... ...and experienced senior scientist to lead the design, development...PlatformContract work$100k - $181.5k
...company’s proprietary ProFoundry Platform integrates state-of-the-art... ..., and computational technologies to systematically identify and... ...SummaryWe are seeking an exceptional Scientist or Senior Scientist to lead... ...and its affiliated Flagship Lab companies (collectively, “FSP...Platform$127k - $205.9k
...driving the creation of new technologies. What sets Flagship apart is... ...seeking a Senior Machine Learning Scientist, Climate and Hydrology to... ...broader environmental modeling platform.This role sits at the... ...and its affiliated Flagship Lab companies (collectively, “FSP...PlatformRemote work$180k - $258.5k
...companies that invent breakthrough technologies in order to transform health... ...therapeutic modalities. Our platform integrates novel small... ...motivated and innovative (Senior) Scientist, Machine Learning to join our... ...and its affiliated Flagship Lab companies (collectively, “FSP...Platform$100k - $180k
...bold scientific ideas. Flagship Labs is our innovation foundry... ...test, and scale breakthrough technologies that can become new bioplatforms... .... We are looking for a scientist with deep hands-on experience... ...practical capabilities for the platform.This is a zero-to-one role for...PlatformFull timePart time
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Principal Scientist, Lab Platform Disruptive Technologies. Be the first to apply!
Related searches
- molecular biology scientist Cambridge, MA
- water quality scientist Cambridge, MA
- machine learning scientist Cambridge, MA
- principal applied scientist Cambridge, MA
- bioanalytical scientist Cambridge, MA
- scientist antibody discovery Cambridge, MA
- image scientist Cambridge, MA
- machine learning research scientist Cambridge, MA
- hplc scientist Cambridge, MA
- materials scientist Cambridge, MA