Pillar Therapeutics- Principal Scientist, Analytical Chemistry

Position The Principal Scientist, Analytical Chemistry will report directly to the Director of Oligonucleotide and Conjugation Chemistry and will interface frequently with members of the delivery group and cross‑functional teams to advance oligonucleotide therapeutic programs. This person will help define and execute the strategy to analyze oligonucleotides and conjugates in an efficient and timely manner. As a lab‑based role, this person will implement and use scientific and analytical equipment to yield high‑quality oligonucleotide and oligonucleotide‑conjugate materials. Responsibilities Define and implement reproducible analytical protocols to characterize oligonucleotides for biological evaluation in our targeted delivery platform. Develop and implement QC methods to determine purity, composition, and concentration of oligonucleotides and conjugates using a toolbox of analytical methods (HPLC, MS, (bio)analytical assays, etc.). Develop and implement analytical methods (e.g., MS) to determine drug‑to‑conjugate ratios of antibody‑oligonucleotide conjugates. Develop and implement analytical methods to determine in‑vitro stability (e.g., serum stability) of oligonucleotides and conjugates. In conjunction with the biology group, assist in development and implementation of analytical methods to determine pharmacokinetics and distribution of oligonucleotides and conjugates in vivo. Assist in internal lab build, procuring and utilizing analytical equipment to characterize oligonucleotides and antibody/peptide‑oligonucleotide conjugates. Assist conjugation scientists in developing methods (SEC, IEX, etc.) to purify oligonucleotide conjugates. Qualifications PhD in chemistry or related discipline with 5+ years of experience working with oligonucleotide therapeutics (siRNA, ASOs, etc.) in the biopharmaceutical industry; or BS/MS with 10+ years. Experience analyzing peptide‑, protein‑, or antibody‑oligonucleotide conjugates, effectively operating in a cross‑functional, collaborative environment. Adept in state‑of‑the‑art analytical methods (SEC, IEX, RP‑HPLC, MS, etc.) to characterize oligonucleotide conjugates. Experience in (bio)analytical assays to determine pharmacokinetic, distribution, and PD profiles of oligonucleotide therapeutics is a plus. Process‑ and detail‑oriented to ensure proper release of high‑quality oligonucleotide material for in‑vivo testing. Effective communicator and proven team‑player, with the ability to operate independently in a laboratory setting. Self‑organized, thoughtful, and brings sound judgement and technical decision‑making abilities. This person will be based on‑site at the company’s headquarters in Cambridge, MA. Compensation Salary base range: $160,000 – $190,000 USD. Final compensation will depend on factors such as experience, skills, and location. The role may also be eligible for an annual bonus and long‑term incentives. #J-18808-Ljbffr