Principal Data Scientist - Immunology - (2 positions)

Principal Data Scientist - Immunology

Johnson & Johnson Innovative Medicine is currently seeking a Principal Data Scientist - Immunology (2 openings) to join our Immunology R&D Data Science & Digital Health team (DSDH). This position will be located on site at one of our offices in either Spring House PA, Cambridge MA, Titusville NJ, Raritan NJ, or San Diego CA (NO fully remote option available).

Johnson and Johnson Innovative Medicine is recruiting for a Principal Data Scientist (Knowledge Graph Engineer) - Immunology, who will play a pivotal role to standardize and connect biomedical and clinical data. You will be a hands-on technical contributor with depth in semantic technologies, ontology, and graph data modeling, plus strong familiarity with the life sciences domain.

You will connect enterprise master data with R&D data across the entire product lifecycle so trusted, interoperable knowledge powers analytics, search, and AI across Johnson and Johnson Innovative Medicine.

Primary Responsibilities:

• Be a key contributor to the design and implementation of a scalable knowledge graph infrastructure focused on data standardization and interoperability, focusing on Immunology R&D data.
• Apply graph-based data modeling for efficient Immunology R&D organization, integration and retrieval to ensure system flexibility and long-term maintainability.
• Work with a larger community of Data Scientists, Clinical Scientists, and Discovery Scientists to standardize, curate and create AI-Ready data sets.
• Curate and extend ontologies for clear mapping into established biomedical ontologies and controlled terminologies using resource description framework (RDF) standards.
• Work with SPARQL/GraphQL/REST services; develop ingestion and curation pipelines to ingest, normalize and map concepts across data sources.
• Extend and curate Immunology R&D-relevant ontologies (e.g., diseases, drugs, targets, pathways, etc.) and maintain synonyms, cross-references, and provenance.
• Partner with cross-functional teams to enable NLP/RAG over graphs, features for predictive modeling and terminology services for search and study design tools.
• Work with Data Science & Digital Health colleagues, IT and DevOps teams to deploy and manage the graph database infrastructure, focusing on high availability, scalability, and recovery operations specifically geared toward Immunology R&D needs and applications.
• Draft and manage documentation, such as data dictionaries, data lineage, and data flow diagrams, to facilitate understanding of the knowledge graph.

Preferred Qualifications:

• Desired Ph.D. or master's degree in bioengineering, computer science, IT, bioinformatics, physics, mathematics, or related fields, emphasis on semantic technologies for biomedical application.
• 5+ years professional experience in health informatics.
• Demonstrated experience in large-scale knowledge graphs construction, ontology development, pharmaceutical or healthcare domains integration.
• Programming background in parser combinators, natural language processing, and linked data (RDF Triple Stores and property graphs).
• Proficiency in semantic web technologies (e.g. SPARQL, RDF, OWL), familiarity with graph databases (Neo4j, Amazon Neptune).
• Proven work with complex biomedical datasets (e.g. clinical, genomics, proteomics)
• Proficiency in various data storage solutions (SQL, key-value, column, document, graph stores) and data modeling techniques (semantic data, ontologies, taxonomies).
• Experience in CI/CD implementations, git usage, CI/CD stacks (Jenkins, GitLab, Azure DevOps), DevOps tools, metrics/monitoring, and containerization technologies (Docker, Singularity).
• Demonstrated stakeholder management capabilities- including requirements gathering, business analysis and planning. Must have the capacity to translate discussions into user requirements and project plans.
• Ability to manage a numerous projects simultaneously, prioritize work, exhibit organizational skills and flexibility to deliver maximum business value.
• Willingness to conduct periodic travel (<15% of time) to conferences and internal meetings.

This position will be located on site at one of our campuses in either Spring House PA, Cambridge MA, Titusville NJ, Raritan NJ, or San Diego, CA (NO fully remote option available). Occasional travel for cross‑functional workshops, design sessions, and team meetings may be required. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.