Sr Director, National Accounts

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.

Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.

Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.

Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!

The Senior Director, National Accounts implements Definium’s market access strategy across assigned commercial payer and PBM accounts and develops account-specific recommendations to support patient access and reimbursement. This role focuses on commercial national accounts and excludes Medicaid and other government accounts.

Primary Responsibilities

• Implement approved market access strategies and develop customer-specific access and reimbursement recommendations
• Own executive relationships with assigned PBMs, national commercial health plans, and other key market access stakeholders
• Lead account planning, customer engagement, and business reviews for assigned accounts
• Engage payer pharmacy, medical, clinical, policy, and reimbursement stakeholders
• Partner cross-functionally to support payer access planning, reimbursement strategy, and customer-specific implementation needs
• Translate approved clinical, outcomes, and economic evidence into payer-relevant discussions
• Generate customer insights and market intelligence to support account planning, launch readiness, and leadership decision-making
• Monitor payer trends, benefit design, formulary and medical policy processes, utilization management, behavioral health management, reimbursement dynamics, and competitive activity

Primary Customers

• National PBMs
• National commercial health plans
• National integrated delivery systems

Required Qualifications

• Bachelor's degree required; advanced degree preferred
• Minimum 10 years of market access, payer, reimbursement, account management, or related biopharmaceutical experience
• Demonstrated experience with national commercial health plans, PBMs, and/or large regional payer accounts
• Experience in CNS, psychiatry, mental health, behavioral health, or other specialty product launches preferred
• Track record implementing market access strategies and achieving account-specific access objectives
• Understanding of payer policy, reimbursement, benefit design, formulary management, and coverage decision-making
• Working knowledge of formulary review, medical policy development, prior authorization, step therapy, and medical versus pharmacy benefit considerations
• Experience translating clinical, HEOR, outcomes, and value evidence into customer-relevant discussions
• Experience engaging payer decision-makers, including P&T committees or similar clinical, pharmacy, medical policy, and value assessment forums
• Strong executive relationship management skills with payer and PBM stakeholders
• Cross-functional collaboration with Medical Affairs, HEOR, Commercial Operations, Patient Services, and Legal/Compliance
• Ability to generate actionable customer insights and market intelligence
• Willingness to travel, typically 50%+
• Knowledge of relevant compliance requirements and payer communication standards

Compliance and PIE-Aligned Communications

Payer communications, including appropriate pre-approval information exchange and healthcare economic information, will be conducted in alignment with approved company materials, Medical/Legal/Regulatory review processes, applicable FDA guidance, PIE guidelines, and company compliance policies. This role will partner closely with internal stakeholders to ensure payer planning discussions are accurate, consistent, and appropriately aligned with approved access, value, and launch readiness objectives.

The starting base pay range for this position is $220,000.00 - $280,000.00. Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location.

Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including:

• 100% paid health benefits including Medical, Dental and Vision for you and your dependents
• 401(k) program with company match and vesting after the turn of the first month after your start date
• Flexible time off
• Generous parental leave and some fun fringe perks!