Senior Scientist, In Vitro (Cardiometabolic Disease)

Job Description: The Cardiometabolic Disease (CMD) department at our company's Research Labs in South San Francisco is seeking a Senior Scientist to join our discovery team. This role offers an exciting opportunity to contribute to cardiovascular drug discovery by developing and applying robust cell-based and ex‑vivo systems to advance understanding of disease biology and mechanism of action. Key Responsibilities Independently design, optimize, and execute cell‑based and ex‑vivo assays to interrogate disease pathways and pharmacologic mechanisms. Lead mechanism‑of‑action studies using molecular, biochemical, and cellular approaches to link target modulation to disease biology. Generate high‑quality, reproducible data and apply critical analysis to guide decision‑making and prioritization. Collaborate effectively with cross‑functional teams to advance cardiovascular drug discovery programs. Incorporate emerging assay technologies to strengthen discovery capabilities. Stay current with scientific advances in cardiovascular and translational biology. Communicate scientific rationale, assay strategies, and key findings clearly to diverse audiences. Maintain rigorous documentation in electronic lab notebooks and contribute to presentations, technical reports, and manuscripts. Qualifications Education: Master's (with 4+ years) or Ph.D. (with 1+ years) in physiology, pharmacology, biomedical sciences or related field and relevant drug discovery experience. Required Experience and Skills Demonstrated expertise in designing, executing, and interpreting in‑vitro and ex‑vivo experiments with high scientific rigor. Proven ability to independently drive experiments, troubleshoot assays, and derive actionable conclusions. Demonstrated creativity and problem‑solving ability in addressing complex biological questions using state‑of‑the‑art in‑vitro approaches (reflected by publications and/or impactful internal contributions). Proficiency in standard molecular, cellular, and biochemical techniques. Strong quantitative skills, including data analysis and application of statistical approaches to biological datasets. Excellent communication and organizational skills, with the ability to manage multiple projects in a matrixed environment. Preferred Experience and Skills Experience with primary or advanced cell culture systems (including 2D and 3D models) in cardiac or vascular biology. Strategic thinker with a background in one or more relevant areas (atherosclerosis, heart failure, inflammation, renal disease, lipid metabolism). Solid understanding of the translational strengths and limitations of in‑vitro models. Experience developing fit‑for‑purpose in‑vitro assays to support compound profiling and mechanism‑based evaluation. Familiarity with multi‑omics approaches (e.g., single‑cell RNA‑seq and proteomics) to support target biology and validation. Understanding of in‑vivo cardiovascular models and physiological endpoints. Required Skills Cardiometabolic Cell Cultures Ex Vivo Assays In Vitro Assays In Vitro Models In Vitro Studies Vascular Biology Salary and Benefits Salary range: $131,400.00 – $206,800.00, based on education, qualifications, experience, and other factors. Successful candidates are eligible for annual bonus and long‑term incentive, if applicable. Comprehensive benefits include medical, dental, vision, healthcare insurance and other benefits for employee and family; retirement benefits including 401(k); paid holidays; vacation; compassionate and sick days. Equal Employment Opportunity We are an Equal Employment Opportunity Employer and provide equal opportunities to all employees and applicants. We prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with affirmative action requirements for protected veterans and individuals with disabilities. #J-18808-Ljbffr MSD Malaysia