Senior Bioinformatics Scientist - Ghobrial Lab

Primary Duties and Responsibilities Design and maintain data architecture systems ensuring proper organization, documentation, and provenance tracking from generation through processing. Manage Google Cloud Platform infrastructure including project lifecycle, access control, and cost monitoring. Collaborate with wet‑lab and computational biology teams to establish data management workflows and quality standards. Develop and optimize bioinformatics pipelines using Nextflow on Google Cloud Batch. Provide technical guidance on data sharing practices and ensure compliance with documentation requirements, institutional and regulatory guidelines. Provide scientific guidance on data analysis for sequencing data. Oversee assigned projects from data generation through delivery and/or publication. Work with leadership to prioritize efforts, set budgets, and assign resources. Ensure success of project computational milestones associated with grants and research efforts. Maintain expertise in the latest research scholarship and advances in the field, providing scientific input on proposals and project direction. Integrate activities across multiple teams to maximize success of overall project output. Ensure effective communication and alignment of efforts across all contributing computational collaborators, both internal and external, and timely reporting of progress to leadership and stakeholders. Proactively identify and work to resolve project roadblocks. Manage internal and external relationships and partnerships pertinent to the objectives of assigned project computational collaborations. Work closely with the leadership team to promote synergy among the various teams and initiatives, advancing the overall scientific planning and research objectives of the lab. Accountable for ensuring project deadlines and contractual obligations are met for assigned projects. Accountable for the compliance of assigned projects. Scientific Leadership Lead, mentor, and supervise the project team of dry‑lab researchers. Contribute critically to strategic planning and scientific direction of the research group’s portfolio of projects. Drive innovation by identifying areas of improvement and development that align with strategic goals. Cultivate a deep understanding of the scientific principles, theories, and methodologies within the hematology precursor space, as well as cutting‑edge technologies and computational methodologies leveraged by the field. Guide research design and computational approach and provide critical feedback on progress. Analyze and interpret scientific data to draw meaningful conclusions and make recommendations for future research direction. Leverage existing multi‑omics data to inform strategic decision‑making and cohort design. Ensure synergy and efficiency in research efforts across interdisciplinary teams, ensuring synergy of the various project contributors. Report on research progress and present results, both formally and informally. Ensure that all research is conducted in compliance with regulatory and contractual obligations, as well as institutional and industry best practices. Key performance indicators for this role include project completion rate, innovation impact of project output, data integrity and quality of project research output, and team development for assigned projects. Knowledge, Skills and Abilities Strong expertise in cloud computing (Google Cloud Platform preferred), including infrastructure management and cost optimization. Proficiency in workflow management systems (Nextflow) and containerization technologies. Experience with data architecture, version control, and reproducible research practices. Demonstrated ability to collaborate across wet‑lab and computational teams with excellent communication skills. Demonstrated experience in complex, large‑scale project or program management. Demonstrated experience managing large databases. Demonstrated experience managing budgets and resources on assigned projects. Demonstrated experience in translational research. Strong competencies in project planning and resource management with the ability to coordinate multiple activities and resources, while maintaining a focus on quality. Impeccable written and oral communication and people skills. Excellent documentation skills. Demonstrated project team management skills. Demonstrated excellence in organizational, problem‑solving, and analytical skills. Highly sophisticated analytical capabilities and impeccable attention to detail. Ability to produce and present clear, concise, and professionally written communications and presentations. Ability to condense highly complex concepts and information and present them in a clear and accessible manner. Ability to clearly define and delegate tasks and deliverables. Ability to manage multiple priorities with tight deadlines. Versatility, flexibility, and a willingness to work with evolving priorities. Demonstrated leadership skills and leads by example. Ability to work with great independence and successfully deliver on that work. Thrives in a fast‑paced, mission‑focused environment. Enjoys working with people of diverse backgrounds. Entrepreneurial, self‑starter and independent. Excellent business software skills. Minimum Job Qualifications Advanced degree preferred. 6+ years experience post‑education; one year management responsibility. License/Certification/Registration Required None Supervisory Responsibilities Manages the work efforts of at least one individual contributor and mentors. Completes performance appraisals. Patient Contact None Equal Employment Opportunity Statement Dana‑Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. Pay Transparency Statement Hiring range is based on market pay structures. Individual salaries are determined by factors such as business needs, market conditions, internal equity, and the candidate’s relevant experience, skills and qualifications. $95,000.00 – $125,100.00 #J-18808-Ljbffr Dana-Farber Cancer Institute